B0TSQ4 (PYRB1_SHEHH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase 1
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase 1
Short name=ATCase 1

Gene names

Name:	pyrB1
Ordered Locus Names:	Shal_0654

Organism

Shewanella halifaxensis (strain HAW-EB4) [Complete proteome] [HAMAP]

Taxonomic identifier

458817 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Aspartate carbamoyltransferase 1 HAMAP MF_00001		PRO_0000334593

Sequences

	Sequence		Length	Mass (Da)
	B0TSQ4 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 8E7CDFB017B9FB28	FASTA	310	34,626
	10 20 30 40 50 60 MSNPLYNKNI ISITDLSRAE LELIVSTANE LKQHPRPDLL KNKVIASCFF EASTRTRLSF 70 80 90 100 110 120 ETAVQRLGGS VIGFPDSGNT SLGKKGETLA DSVQVISSYS DAFFMRHNQE GAARLASEFS 130 140 150 160 170 180 SVPVINGGDG SNQHPTQTLL DLFSIYETQG TLDKLQVAFV GDLKYGRTVH SLTQALSLFD 190 200 210 220 230 240 CEFHFVAPPA LSMPEYIIDE LKEKGCTFTQ YDSLDGVLSK LDILYMTRVQ KERFDETEYQ 250 260 270 280 290 300 HMKSSFILTA QMFEGVKDNL KVLHPLPRVD EITTDVDSTP YAYYFQQAKN GVYARQALLA 310 LVLTNEFGDK

References

[1]

"Complete sequence of Shewanella halifaxensis HAW-EB4." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Kim E., Zhao J.-S., Richardson P. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HAW-EB4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000931 Genomic DNA. Translation: ABZ75229.1.
RefSeq	YP_001672888.1. NC_010334.1.
3D structure databases
ProteinModelPortal	B0TSQ4.
SMR	B0TSQ4. Positions 2-309.
ModBase	Search...
Protein-protein interaction databases
STRING	B0TSQ4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5906714.
GenomeReviews	Gene locus Shal_0654 in contig CP000931_GR.
KEGG	shl:Shal_0654.
PATRIC	23503780. VBISheHal24697_0687.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG579429.
OMA	MEEWEIT.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	SHAL458817:SHAL_0654-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB1_SHEHH

Accession

Primary (citable) accession number: B0TSQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 8, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program