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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciSHAL458817:G1GB1-3545-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Shal_3373
OrganismiShewanella halifaxensis (strain HAW-EB4)
Taxonomic identifieri458817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000001317 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000832141 – 966Glycine dehydrogenase (decarboxylating)Add BLAST966

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei713N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiB0TSG5

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi458817.Shal_3373

Structurei

3D structure databases

ProteinModelPortaliB0TSG5
SMRiB0TSG5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

B0TSG5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTETLTQLE QHELFIRRHI GPESTQQQEM LNFVGAESLE DLTQQIVPGS
60 70 80 90 100
IRLNRDLAVG SSCSEAEGMA YIREVADKNK VFKSYIGMGY YGTEVPSVIQ
110 120 130 140 150
RNVFENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASASLLD
160 170 180 190 200
EATAAAEAMA LAKRVSKAKK ANIFFIADDV FPQTIDVVKT RAECFGFDIV
210 220 230 240 250
VGPASDAVNY ELFGALFQYT NRFGEISDHT ALFAELKAKK AVVTVAADMM
260 270 280 290 300
SLVLLKSPGS MGADVVFGSA QRFGVPMGFG GPHAAFFVTR DEYKRSLPGR
310 320 330 340 350
IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV
360 370 380 390 400
YHGPQGLKVI AERIHRLTDI LAAGLTAKGL ELVNSTWFDT ITVKGGDVAA
410 420 430 440 450
INARALAAQI NLRIDSANDN AGSFGISLDE TTTRTDVSEL FDVILGSEHG
460 470 480 490 500
LDVAALDEQI IKADSASIPS ELVRTDAILT HPTFNRYHSE TEMMRYIKRL
510 520 530 540 550
ENKDLALNHS MISLGSCTMK LNAATEMMPV SWAEFGNMHP FCPLDQAEGY
560 570 580 590 600
TQLIEELSAW LVDITGYDAM CMQANSGASG EYAGLLAIRN YHISRGEGHR
610 620 630 640 650
NVCLIPQSAH GTNPASAQLA GMKIVVTACD KAGNVDMEDL KTKAAEVADN
660 670 680 690 700
LSCIMITYPS THGVYEETVS EICDIIHQHG GQVYLDGANM NAQVGLTTPG
710 720 730 740 750
SIGADVSHLN LHKTFAIPHG GGGPGMGPIG VKAHLAPFVA GHSVVKPGRE
760 770 780 790 800
SDNNGAVSAA PYGSASILPI TWMYIKLLGY QGLRQSTQVA LLNANYVMKK
810 820 830 840 850
LSAHYPVLYT GRNDRVAHEC IIDLRPLKEA SGVTEMDIAK RLNDYGFHAP
860 870 880 890 900
TMSFPVAGTL MIEPTESESK VELDRFIEAM VSIRAEIAKV ESGEWPVDNN
910 920 930 940 950
PLHNAPHTLA DIMDPAFDER PYTRQEAVFP TAAVKANKFW PTVNRIDDVY
960
GDRNLMCSCA PVSDYE
Length:966
Mass (Da):105,222
Last modified:April 8, 2008 - v1
Checksum:i6E472F25B12C8C79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000931 Genomic DNA Translation: ABZ77919.1
RefSeqiWP_012278439.1, NC_010334.1

Genome annotation databases

EnsemblBacteriaiABZ77919; ABZ77919; Shal_3373
KEGGishl:Shal_3373

Similar proteinsi

Entry informationi

Entry nameiGCSP_SHEHH
AccessioniPrimary (citable) accession number: B0TSG5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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