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B0TSG5 (GCSP_SHEHH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:Shal_3373
OrganismShewanella halifaxensis (strain HAW-EB4) [Complete proteome] [HAMAP]
Taxonomic identifier458817 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length966 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 966966Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000083214

Amino acid modifications

Modified residue7131N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B0TSG5 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 6E472F25B12C8C79

FASTA966105,222
        10         20         30         40         50         60 
MTTETLTQLE QHELFIRRHI GPESTQQQEM LNFVGAESLE DLTQQIVPGS IRLNRDLAVG 

        70         80         90        100        110        120 
SSCSEAEGMA YIREVADKNK VFKSYIGMGY YGTEVPSVIQ RNVFENPGWY TAYTPYQPEI 

       130        140        150        160        170        180 
AQGRLEAILN FQQVSMDLTG LDLASASLLD EATAAAEAMA LAKRVSKAKK ANIFFIADDV 

       190        200        210        220        230        240 
FPQTIDVVKT RAECFGFDIV VGPASDAVNY ELFGALFQYT NRFGEISDHT ALFAELKAKK 

       250        260        270        280        290        300 
AVVTVAADMM SLVLLKSPGS MGADVVFGSA QRFGVPMGFG GPHAAFFVTR DEYKRSLPGR 

       310        320        330        340        350        360 
IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV YHGPQGLKVI 

       370        380        390        400        410        420 
AERIHRLTDI LAAGLTAKGL ELVNSTWFDT ITVKGGDVAA INARALAAQI NLRIDSANDN 

       430        440        450        460        470        480 
AGSFGISLDE TTTRTDVSEL FDVILGSEHG LDVAALDEQI IKADSASIPS ELVRTDAILT 

       490        500        510        520        530        540 
HPTFNRYHSE TEMMRYIKRL ENKDLALNHS MISLGSCTMK LNAATEMMPV SWAEFGNMHP 

       550        560        570        580        590        600 
FCPLDQAEGY TQLIEELSAW LVDITGYDAM CMQANSGASG EYAGLLAIRN YHISRGEGHR 

       610        620        630        640        650        660 
NVCLIPQSAH GTNPASAQLA GMKIVVTACD KAGNVDMEDL KTKAAEVADN LSCIMITYPS 

       670        680        690        700        710        720 
THGVYEETVS EICDIIHQHG GQVYLDGANM NAQVGLTTPG SIGADVSHLN LHKTFAIPHG 

       730        740        750        760        770        780 
GGGPGMGPIG VKAHLAPFVA GHSVVKPGRE SDNNGAVSAA PYGSASILPI TWMYIKLLGY 

       790        800        810        820        830        840 
QGLRQSTQVA LLNANYVMKK LSAHYPVLYT GRNDRVAHEC IIDLRPLKEA SGVTEMDIAK 

       850        860        870        880        890        900 
RLNDYGFHAP TMSFPVAGTL MIEPTESESK VELDRFIEAM VSIRAEIAKV ESGEWPVDNN 

       910        920        930        940        950        960 
PLHNAPHTLA DIMDPAFDER PYTRQEAVFP TAAVKANKFW PTVNRIDDVY GDRNLMCSCA 


PVSDYE 

« Hide

References

[1]"Complete sequence of Shewanella halifaxensis HAW-EB4."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Kim E., Zhao J.-S., Richardson P.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HAW-EB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000931 Genomic DNA. Translation: ABZ77919.1.
RefSeqYP_001675578.1. NC_010334.1.

3D structure databases

ProteinModelPortalB0TSG5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING458817.Shal_3373.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABZ77919; ABZ77919; Shal_3373.
GeneID5903477.
KEGGshl:Shal_3373.
PATRIC23509702. VBISheHal24697_3538.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycSHAL458817:GH1X-3493-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_SHEHH
AccessionPrimary (citable) accession number: B0TSG5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families