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B0TSG5

- GCSP_SHEHH

UniProt

B0TSG5 - GCSP_SHEHH

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciSHAL458817:GH1X-3493-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:Shal_3373
    OrganismiShewanella halifaxensis (strain HAW-EB4)
    Taxonomic identifieri458817 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000001317: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 966966Glycine dehydrogenase (decarboxylating)PRO_1000083214Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei713 – 7131N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi458817.Shal_3373.

    Structurei

    3D structure databases

    ProteinModelPortaliB0TSG5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0TSG5-1 [UniParc]FASTAAdd to Basket

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    MTTETLTQLE QHELFIRRHI GPESTQQQEM LNFVGAESLE DLTQQIVPGS    50
    IRLNRDLAVG SSCSEAEGMA YIREVADKNK VFKSYIGMGY YGTEVPSVIQ 100
    RNVFENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASASLLD 150
    EATAAAEAMA LAKRVSKAKK ANIFFIADDV FPQTIDVVKT RAECFGFDIV 200
    VGPASDAVNY ELFGALFQYT NRFGEISDHT ALFAELKAKK AVVTVAADMM 250
    SLVLLKSPGS MGADVVFGSA QRFGVPMGFG GPHAAFFVTR DEYKRSLPGR 300
    IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV 350
    YHGPQGLKVI AERIHRLTDI LAAGLTAKGL ELVNSTWFDT ITVKGGDVAA 400
    INARALAAQI NLRIDSANDN AGSFGISLDE TTTRTDVSEL FDVILGSEHG 450
    LDVAALDEQI IKADSASIPS ELVRTDAILT HPTFNRYHSE TEMMRYIKRL 500
    ENKDLALNHS MISLGSCTMK LNAATEMMPV SWAEFGNMHP FCPLDQAEGY 550
    TQLIEELSAW LVDITGYDAM CMQANSGASG EYAGLLAIRN YHISRGEGHR 600
    NVCLIPQSAH GTNPASAQLA GMKIVVTACD KAGNVDMEDL KTKAAEVADN 650
    LSCIMITYPS THGVYEETVS EICDIIHQHG GQVYLDGANM NAQVGLTTPG 700
    SIGADVSHLN LHKTFAIPHG GGGPGMGPIG VKAHLAPFVA GHSVVKPGRE 750
    SDNNGAVSAA PYGSASILPI TWMYIKLLGY QGLRQSTQVA LLNANYVMKK 800
    LSAHYPVLYT GRNDRVAHEC IIDLRPLKEA SGVTEMDIAK RLNDYGFHAP 850
    TMSFPVAGTL MIEPTESESK VELDRFIEAM VSIRAEIAKV ESGEWPVDNN 900
    PLHNAPHTLA DIMDPAFDER PYTRQEAVFP TAAVKANKFW PTVNRIDDVY 950
    GDRNLMCSCA PVSDYE 966
    Length:966
    Mass (Da):105,222
    Last modified:April 8, 2008 - v1
    Checksum:i6E472F25B12C8C79
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000931 Genomic DNA. Translation: ABZ77919.1.
    RefSeqiYP_001675578.1. NC_010334.1.

    Genome annotation databases

    EnsemblBacteriaiABZ77919; ABZ77919; Shal_3373.
    GeneIDi5903477.
    KEGGishl:Shal_3373.
    PATRICi23509702. VBISheHal24697_3538.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000931 Genomic DNA. Translation: ABZ77919.1 .
    RefSeqi YP_001675578.1. NC_010334.1.

    3D structure databases

    ProteinModelPortali B0TSG5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 458817.Shal_3373.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABZ77919 ; ABZ77919 ; Shal_3373 .
    GeneIDi 5903477.
    KEGGi shl:Shal_3373.
    PATRICi 23509702. VBISheHal24697_3538.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci SHAL458817:GH1X-3493-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HAW-EB4.

    Entry informationi

    Entry nameiGCSP_SHEHH
    AccessioniPrimary (citable) accession number: B0TSG5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3