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B0TSG5

- GCSP_SHEHH

UniProt

B0TSG5 - GCSP_SHEHH

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, Shal_3373
Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSHAL458817:GH1X-3493-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:Shal_3373
OrganismiShewanella halifaxensis (strain HAW-EB4)
Taxonomic identifieri458817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001317: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 966966Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000083214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei713 – 7131N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi458817.Shal_3373.

Structurei

3D structure databases

ProteinModelPortaliB0TSG5.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B0TSG5-1 [UniParc]FASTAAdd to Basket

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MTTETLTQLE QHELFIRRHI GPESTQQQEM LNFVGAESLE DLTQQIVPGS    50
IRLNRDLAVG SSCSEAEGMA YIREVADKNK VFKSYIGMGY YGTEVPSVIQ 100
RNVFENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASASLLD 150
EATAAAEAMA LAKRVSKAKK ANIFFIADDV FPQTIDVVKT RAECFGFDIV 200
VGPASDAVNY ELFGALFQYT NRFGEISDHT ALFAELKAKK AVVTVAADMM 250
SLVLLKSPGS MGADVVFGSA QRFGVPMGFG GPHAAFFVTR DEYKRSLPGR 300
IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV 350
YHGPQGLKVI AERIHRLTDI LAAGLTAKGL ELVNSTWFDT ITVKGGDVAA 400
INARALAAQI NLRIDSANDN AGSFGISLDE TTTRTDVSEL FDVILGSEHG 450
LDVAALDEQI IKADSASIPS ELVRTDAILT HPTFNRYHSE TEMMRYIKRL 500
ENKDLALNHS MISLGSCTMK LNAATEMMPV SWAEFGNMHP FCPLDQAEGY 550
TQLIEELSAW LVDITGYDAM CMQANSGASG EYAGLLAIRN YHISRGEGHR 600
NVCLIPQSAH GTNPASAQLA GMKIVVTACD KAGNVDMEDL KTKAAEVADN 650
LSCIMITYPS THGVYEETVS EICDIIHQHG GQVYLDGANM NAQVGLTTPG 700
SIGADVSHLN LHKTFAIPHG GGGPGMGPIG VKAHLAPFVA GHSVVKPGRE 750
SDNNGAVSAA PYGSASILPI TWMYIKLLGY QGLRQSTQVA LLNANYVMKK 800
LSAHYPVLYT GRNDRVAHEC IIDLRPLKEA SGVTEMDIAK RLNDYGFHAP 850
TMSFPVAGTL MIEPTESESK VELDRFIEAM VSIRAEIAKV ESGEWPVDNN 900
PLHNAPHTLA DIMDPAFDER PYTRQEAVFP TAAVKANKFW PTVNRIDDVY 950
GDRNLMCSCA PVSDYE 966
Length:966
Mass (Da):105,222
Last modified:April 8, 2008 - v1
Checksum:i6E472F25B12C8C79
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000931 Genomic DNA. Translation: ABZ77919.1.
RefSeqiYP_001675578.1. NC_010334.1.

Genome annotation databases

EnsemblBacteriaiABZ77919; ABZ77919; Shal_3373.
GeneIDi5903477.
KEGGishl:Shal_3373.
PATRICi23509702. VBISheHal24697_3538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000931 Genomic DNA. Translation: ABZ77919.1 .
RefSeqi YP_001675578.1. NC_010334.1.

3D structure databases

ProteinModelPortali B0TSG5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 458817.Shal_3373.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ77919 ; ABZ77919 ; Shal_3373 .
GeneIDi 5903477.
KEGGi shl:Shal_3373.
PATRICi 23509702. VBISheHal24697_3538.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SHAL458817:GH1X-3493-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB4.

Entry informationi

Entry nameiGCSP_SHEHH
AccessioniPrimary (citable) accession number: B0TSG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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