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B0TSG5

- GCSP_SHEHH

UniProt

B0TSG5 - GCSP_SHEHH

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciSHAL458817:GH1X-3493-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:Shal_3373
OrganismiShewanella halifaxensis (strain HAW-EB4)
Taxonomic identifieri458817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001317: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 966966Glycine dehydrogenase (decarboxylating)PRO_1000083214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei713 – 7131N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi458817.Shal_3373.

Structurei

3D structure databases

ProteinModelPortaliB0TSG5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B0TSG5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTETLTQLE QHELFIRRHI GPESTQQQEM LNFVGAESLE DLTQQIVPGS
60 70 80 90 100
IRLNRDLAVG SSCSEAEGMA YIREVADKNK VFKSYIGMGY YGTEVPSVIQ
110 120 130 140 150
RNVFENPGWY TAYTPYQPEI AQGRLEAILN FQQVSMDLTG LDLASASLLD
160 170 180 190 200
EATAAAEAMA LAKRVSKAKK ANIFFIADDV FPQTIDVVKT RAECFGFDIV
210 220 230 240 250
VGPASDAVNY ELFGALFQYT NRFGEISDHT ALFAELKAKK AVVTVAADMM
260 270 280 290 300
SLVLLKSPGS MGADVVFGSA QRFGVPMGFG GPHAAFFVTR DEYKRSLPGR
310 320 330 340 350
IIGVSQDTRG NRALRMAMQT REQHIRREKA NSNICTAQVL LANMASFYAV
360 370 380 390 400
YHGPQGLKVI AERIHRLTDI LAAGLTAKGL ELVNSTWFDT ITVKGGDVAA
410 420 430 440 450
INARALAAQI NLRIDSANDN AGSFGISLDE TTTRTDVSEL FDVILGSEHG
460 470 480 490 500
LDVAALDEQI IKADSASIPS ELVRTDAILT HPTFNRYHSE TEMMRYIKRL
510 520 530 540 550
ENKDLALNHS MISLGSCTMK LNAATEMMPV SWAEFGNMHP FCPLDQAEGY
560 570 580 590 600
TQLIEELSAW LVDITGYDAM CMQANSGASG EYAGLLAIRN YHISRGEGHR
610 620 630 640 650
NVCLIPQSAH GTNPASAQLA GMKIVVTACD KAGNVDMEDL KTKAAEVADN
660 670 680 690 700
LSCIMITYPS THGVYEETVS EICDIIHQHG GQVYLDGANM NAQVGLTTPG
710 720 730 740 750
SIGADVSHLN LHKTFAIPHG GGGPGMGPIG VKAHLAPFVA GHSVVKPGRE
760 770 780 790 800
SDNNGAVSAA PYGSASILPI TWMYIKLLGY QGLRQSTQVA LLNANYVMKK
810 820 830 840 850
LSAHYPVLYT GRNDRVAHEC IIDLRPLKEA SGVTEMDIAK RLNDYGFHAP
860 870 880 890 900
TMSFPVAGTL MIEPTESESK VELDRFIEAM VSIRAEIAKV ESGEWPVDNN
910 920 930 940 950
PLHNAPHTLA DIMDPAFDER PYTRQEAVFP TAAVKANKFW PTVNRIDDVY
960
GDRNLMCSCA PVSDYE
Length:966
Mass (Da):105,222
Last modified:April 8, 2008 - v1
Checksum:i6E472F25B12C8C79
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000931 Genomic DNA. Translation: ABZ77919.1.
RefSeqiYP_001675578.1. NC_010334.1.

Genome annotation databases

EnsemblBacteriaiABZ77919; ABZ77919; Shal_3373.
GeneIDi5903477.
KEGGishl:Shal_3373.
PATRICi23509702. VBISheHal24697_3538.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000931 Genomic DNA. Translation: ABZ77919.1 .
RefSeqi YP_001675578.1. NC_010334.1.

3D structure databases

ProteinModelPortali B0TSG5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 458817.Shal_3373.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ77919 ; ABZ77919 ; Shal_3373 .
GeneIDi 5903477.
KEGGi shl:Shal_3373.
PATRICi 23509702. VBISheHal24697_3538.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci SHAL458817:GH1X-3493-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB4.

Entry informationi

Entry nameiGCSP_SHEHH
AccessioniPrimary (citable) accession number: B0TSG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3