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Protein

Catalase-peroxidase

Gene

katG

Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei89 – 891Transition state stabilizerUniRule annotation
Active sitei93 – 931Proton acceptorUniRule annotation
Metal bindingi261 – 2611Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciSHAL458817:GH1X-1950-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Shal_1888
OrganismiShewanella halifaxensis (strain HAW-EB4)
Taxonomic identifieri458817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000001317 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 718718Catalase-peroxidasePRO_0000354919Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki92 ↔ 220Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-246)UniRule annotation
Cross-linki220 ↔ 246Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-92)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi458817.Shal_1888.

Structurei

3D structure databases

ProteinModelPortaliB0TRN5.
SMRiB0TRN5. Positions 19-718.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0TRN5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKKCPVMH GGATEISMSN MEWWPKALNL DILHQHDSKT NPMGAGFNYR
60 70 80 90 100
EQVKLLDVEA LKKDLHALMT DSQPWWPADW GHYGGLMIRL SWHAAGTYRT
110 120 130 140 150
ADGRGGAGRG NQRFAPLNSW PDNVNLDKAR RLLWPLKKKY GNKLSWADLI
160 170 180 190 200
AYAGTIAYES MGLKTFGFAF GREDIWHPEK DIYWGAEKEW LAPSGSEGSR
210 220 230 240 250
YSGERDLENP LASVMMGLIY VNPEGVDGHP DPLKTANDVR VTFERMAMND
260 270 280 290 300
EETVALTAGG HTVGKCHGNG DAELLGPVPE GADVEDQGLG WINKSQRGIG
310 320 330 340 350
RDTVSSGLEG AWTTHPTQWD NGYFTLLLNH EWQLNKSPAG AWQWEPINIK
360 370 380 390 400
EEDKPVDVED LTQRYNPIMT DADMAMKLDP DYQIISARFD KDPEYFSDVF
410 420 430 440 450
ARTWFKLTHR DMGPKTRYIG PDVPAVDLLW QDPVPKGRSD YDVEAVKAQI
460 470 480 490 500
AASSLSVSDM VTTAWDSART FRGSDLRGGA NGARIRLAPQ RDWQANEPER
510 520 530 540 550
LNRVLAVLEP IAAKSGVSVA DVIVLAGNLA VEQAAKAAGF AIKVPFSPGR
560 570 580 590 600
GDATADMTDV ESFHVLEPLH DGYRNWLKKD YAVSAEELML DQTQLLGLTA
610 620 630 640 650
QEMTVLLGGM RVLGTNYNGE SHGAFTEHQG ALTNDFFVNL TDMNNTWQPV
660 670 680 690 700
SNNLYEISDR ETAKLKWTAT RVDLVFGSNS ILRAYAEVYA QDDNQQKFVE
710
DFVTTWAKVM NSDRFDLD
Length:718
Mass (Da):80,069
Last modified:April 8, 2008 - v1
Checksum:i1537EFDAD42FE9E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000931 Genomic DNA. Translation: ABZ76453.1.
RefSeqiWP_012276985.1. NC_010334.1.

Genome annotation databases

EnsemblBacteriaiABZ76453; ABZ76453; Shal_1888.
KEGGishl:Shal_1888.
PATRICi23506467. VBISheHal24697_1981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000931 Genomic DNA. Translation: ABZ76453.1.
RefSeqiWP_012276985.1. NC_010334.1.

3D structure databases

ProteinModelPortaliB0TRN5.
SMRiB0TRN5. Positions 19-718.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi458817.Shal_1888.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABZ76453; ABZ76453; Shal_1888.
KEGGishl:Shal_1888.
PATRICi23506467. VBISheHal24697_1981.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.
OrthoDBiPOG091H05R1.

Enzyme and pathway databases

BioCyciSHAL458817:GH1X-1950-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_SHEHH
AccessioniPrimary (citable) accession number: B0TRN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: April 8, 2008
Last modified: September 7, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.