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B0TR44

- SYL_SHEHH

UniProt

B0TR44 - SYL_SHEHH

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei621 – 6211ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSHAL458817:GH1X-3340-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Shal_3228
    OrganismiShewanella halifaxensis (strain HAW-EB4)
    Taxonomic identifieri458817 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000001317: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 859859Leucine--tRNA ligasePRO_0000334818Add
    BLAST

    Proteomic databases

    PRIDEiB0TR44.

    Interactioni

    Protein-protein interaction databases

    STRINGi458817.Shal_3228.

    Structurei

    3D structure databases

    ProteinModelPortaliB0TR44.
    SMRiB0TR44. Positions 228-412.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi618 – 6225"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0TR44-1 [UniParc]FASTAAdd to Basket

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    MQEQYTPSEI EAKVQQHWQD TKTFEVTEDA NKEKFYCLSM FPYPSGRLHM    50
    GHVRNYTIGD VVSRYQRLQG KNVLQPIGWD SFGLPAENAA IKNSTAPAPW 100
    TYENIDYMKN QLKMLGFGYD WSREIATCTP EYYRWEQWFF TKLYEKGLVY 150
    KKTSSVNWCP NDETVLANEQ VIDGCCWRCD TTVEQKEIPQ WFIKITEYAE 200
    ELLNDLDQLD EWPEQVKTMQ RNWIGRSEGI EMTFQVADSD QSFDIYTTRP 250
    DTVMGVTYVA IAAGHPLAEQ AAINNPALAE FIEECKNADT TEAAMAAMEK 300
    KGVATGLNAI HPITGKEVPI WVGNFVLMNY GTGAVMSVPA HDQRDYEFAK 350
    KYSLNIEAVV KPADGEVDIS EEAYTEKGVL FNSAEFDGLD FQAAFDAIDA 400
    KLTAEGKGKR QVNFRLRDWG VSRQRYWGAP IPMVTLADGT VIPTPEDQLP 450
    VILPEDVVMD GIQSPIKSDK EWAKTTVNGQ EAFRETDTFD TFMESSWYYA 500
    RYCSPHADQM LDPAKANYWL PVDQYIGGIE HACMHLLYFR FFHKLLRDSG 550
    LVNSDEPAKR LLTQGMVLAD AYYYNNEKGA RVWVAPSDVT VLETDDKGRT 600
    VKAVDSEGNE LVYTGMSKMS KSKNNGIDPQ EMVDKYGADT VRLFMMFAAP 650
    PELTLEWQES SVEGAHRFIK RLWKTAHDHI ATGPTAELDV KSLNAAQKEL 700
    RRELHKTIAK VGDDIERRQM FNTAIASVME LMNRLQKAPS ETEQDKALMQ 750
    EALNAVVRLL YPIIPHTCFV LWNDLGNQGA IEDVLWPEVD ESALVEDSKL 800
    IIVQVNGKLR AKITVAADAS KEEVETAGMA EEGVVKHTEG KTVRKVIYVP 850
    GKLLNIVAN 859
    Length:859
    Mass (Da):97,166
    Last modified:May 20, 2008 - v2
    Checksum:iAC6E2982B3F9764E
    GO

    Sequence cautioni

    The sequence ABZ77775.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000931 Genomic DNA. Translation: ABZ77775.1. Different initiation.
    RefSeqiYP_001675434.1. NC_010334.1.

    Genome annotation databases

    EnsemblBacteriaiABZ77775; ABZ77775; Shal_3228.
    GeneIDi5906673.
    KEGGishl:Shal_3228.
    PATRICi23509375. VBISheHal24697_3383.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000931 Genomic DNA. Translation: ABZ77775.1 . Different initiation.
    RefSeqi YP_001675434.1. NC_010334.1.

    3D structure databases

    ProteinModelPortali B0TR44.
    SMRi B0TR44. Positions 228-412.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 458817.Shal_3228.

    Proteomic databases

    PRIDEi B0TR44.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABZ77775 ; ABZ77775 ; Shal_3228 .
    GeneIDi 5906673.
    KEGGi shl:Shal_3228.
    PATRICi 23509375. VBISheHal24697_3383.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SHAL458817:GH1X-3340-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HAW-EB4.

    Entry informationi

    Entry nameiSYL_SHEHH
    AccessioniPrimary (citable) accession number: B0TR44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3