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B0TR44

- SYL_SHEHH

UniProt

B0TR44 - SYL_SHEHH

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei621 – 6211ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSHAL458817:GH1X-3340-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Shal_3228
OrganismiShewanella halifaxensis (strain HAW-EB4)
Taxonomic identifieri458817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001317: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 859859Leucine--tRNA ligasePRO_0000334818Add
BLAST

Proteomic databases

PRIDEiB0TR44.

Interactioni

Protein-protein interaction databases

STRINGi458817.Shal_3228.

Structurei

3D structure databases

ProteinModelPortaliB0TR44.
SMRiB0TR44. Positions 228-412.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi618 – 6225"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0TR44 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEQYTPSEI EAKVQQHWQD TKTFEVTEDA NKEKFYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VVSRYQRLQG KNVLQPIGWD SFGLPAENAA IKNSTAPAPW
110 120 130 140 150
TYENIDYMKN QLKMLGFGYD WSREIATCTP EYYRWEQWFF TKLYEKGLVY
160 170 180 190 200
KKTSSVNWCP NDETVLANEQ VIDGCCWRCD TTVEQKEIPQ WFIKITEYAE
210 220 230 240 250
ELLNDLDQLD EWPEQVKTMQ RNWIGRSEGI EMTFQVADSD QSFDIYTTRP
260 270 280 290 300
DTVMGVTYVA IAAGHPLAEQ AAINNPALAE FIEECKNADT TEAAMAAMEK
310 320 330 340 350
KGVATGLNAI HPITGKEVPI WVGNFVLMNY GTGAVMSVPA HDQRDYEFAK
360 370 380 390 400
KYSLNIEAVV KPADGEVDIS EEAYTEKGVL FNSAEFDGLD FQAAFDAIDA
410 420 430 440 450
KLTAEGKGKR QVNFRLRDWG VSRQRYWGAP IPMVTLADGT VIPTPEDQLP
460 470 480 490 500
VILPEDVVMD GIQSPIKSDK EWAKTTVNGQ EAFRETDTFD TFMESSWYYA
510 520 530 540 550
RYCSPHADQM LDPAKANYWL PVDQYIGGIE HACMHLLYFR FFHKLLRDSG
560 570 580 590 600
LVNSDEPAKR LLTQGMVLAD AYYYNNEKGA RVWVAPSDVT VLETDDKGRT
610 620 630 640 650
VKAVDSEGNE LVYTGMSKMS KSKNNGIDPQ EMVDKYGADT VRLFMMFAAP
660 670 680 690 700
PELTLEWQES SVEGAHRFIK RLWKTAHDHI ATGPTAELDV KSLNAAQKEL
710 720 730 740 750
RRELHKTIAK VGDDIERRQM FNTAIASVME LMNRLQKAPS ETEQDKALMQ
760 770 780 790 800
EALNAVVRLL YPIIPHTCFV LWNDLGNQGA IEDVLWPEVD ESALVEDSKL
810 820 830 840 850
IIVQVNGKLR AKITVAADAS KEEVETAGMA EEGVVKHTEG KTVRKVIYVP

GKLLNIVAN
Length:859
Mass (Da):97,166
Last modified:May 20, 2008 - v2
Checksum:iAC6E2982B3F9764E
GO

Sequence cautioni

The sequence ABZ77775.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000931 Genomic DNA. Translation: ABZ77775.1. Different initiation.
RefSeqiYP_001675434.1. NC_010334.1.

Genome annotation databases

EnsemblBacteriaiABZ77775; ABZ77775; Shal_3228.
GeneIDi5906673.
KEGGishl:Shal_3228.
PATRICi23509375. VBISheHal24697_3383.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000931 Genomic DNA. Translation: ABZ77775.1 . Different initiation.
RefSeqi YP_001675434.1. NC_010334.1.

3D structure databases

ProteinModelPortali B0TR44.
SMRi B0TR44. Positions 228-412.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 458817.Shal_3228.

Proteomic databases

PRIDEi B0TR44.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ77775 ; ABZ77775 ; Shal_3228 .
GeneIDi 5906673.
KEGGi shl:Shal_3228.
PATRICi 23509375. VBISheHal24697_3383.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SHAL458817:GH1X-3340-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB4.

Entry informationi

Entry nameiSYL_SHEHH
AccessioniPrimary (citable) accession number: B0TR44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: October 29, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3