B0TQY6 (PUR7_SHEHH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6

Alternative name(s):
SAICAR synthetase

Gene names

Name:	purC
Ordered Locus Names:	Shal_1816

Organism

Shewanella halifaxensis (strain HAW-EB4) [Complete proteome] [HAMAP]

Taxonomic identifier

458817 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137		PRO_1000117849

Sequences

	Sequence		Length	Mass (Da)
	B0TQY6 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 9ED18E51BC26A8C7	FASTA	367	41,400
	10 20 30 40 50 60 MNLADKVLVV NDNLPIRTNK PVHSGKVRSV YWLTEEDSAR LIKDKGYDVP ADAPLAIMVI 70 80 90 100 110 120 SDRISAFDCV WQGENGLNGV PGKGTALNAI SNHWFKLFKD KGLADSHILD IPHPLVWIVQ 130 140 150 160 170 180 KARPVMIEAI ARQYITGSMW RSYTKGEREF CGITIPEGLE KDQKLPELLI TPSTKGVLTG 190 200 210 220 230 240 LEGVPEADDV NVSRSDIERH VEGFNFTKLA DIDLYEKLLK EGFDVISDAL AEHDQVFVDT 250 260 270 280 290 300 KFEFGYVNDA AGNEKLIYMD EVGTPDSSRI WDGSSHRDGK IIEQSKEGFR QWLLNHFPDS 310 320 330 340 350 360 DILLNKNRME ERFALARDNK LPESVMMDIS NTYVGIAEKV IGSKLKISEN PKQEIIDILR EEYQLIV

References

[1]

"Complete sequence of Shewanella halifaxensis HAW-EB4." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Kim E., Zhao J.-S., Richardson P. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HAW-EB4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000931 Genomic DNA. Translation: ABZ76381.1.
RefSeq	YP_001674040.1. NC_010334.1.
3D structure databases
ProteinModelPortal	B0TQY6.
ModBase	Search...
Protein-protein interaction databases
STRING	B0TQY6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5904392.
GenomeReviews	Gene locus Shal_1816 in contig CP000931_GR.
KEGG	shl:Shal_1816.
PATRIC	23506309. VBISheHal24697_1905.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG555040.
OMA	SSRIWDG.
ProtClustDB	PRK13960.
Enzyme and pathway databases
BioCyc	SHAL458817:SHAL_1816-MONOMER.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR014106. PurC_vibrio. IPR001636. SAICAR_synth. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR02735. PurC_vibrio. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. False negative. PS01058. SAICAR_SYNTHETASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_SHEHH

Accession

Primary (citable) accession number: B0TQY6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 8, 2008
Last modified:	January 25, 2012
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program