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B0TQX3 (SPEA_SHEHH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:Shal_1803
OrganismShewanella halifaxensis (strain HAW-EB4) [Complete proteome] [HAMAP]
Taxonomic identifier458817 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length637 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Pathway

Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 637637Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_1000087407

Regions

Region286 – 29611Substrate-binding Potential

Amino acid modifications

Modified residue1011N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B0TQX3 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 17A13A3F53418DA9

FASTA63771,120
        10         20         30         40         50         60 
MSNWSIDDAR ASYNVNHWSQ GLYGISDDGE VTVSPDPSRP ECKIGLNEMA KDMVKSGVAL 

        70         80         90        100        110        120 
PVLVRFPQIL HHRVNSLCQA FNQAIQKYQY ENDYLLVYPI KVNQQQTVVE EILASQVEKE 

       130        140        150        160        170        180 
VPQLGLEAGS KPELMAVLAM AQKASSVIIC NGYKDKEYIR LALIGEKLGH KVYIVLEKIS 

       190        200        210        220        230        240 
ELKVVLEQAK ELGVTPRLGL RVRLAFQGKG KWQASGGEKS KFGLSAAQVL QVITSLKQEN 

       250        260        270        280        290        300 
MLDSLELLHF HLGSQIANIR DIRQGVSEAG RFYCELMKLG ANVKCFDVGG GLAVDYDGTR 

       310        320        330        340        350        360 
SQSSHSMNYG LTEYANNIVS VLTDMCKEYE QPMPRIISES GRYLTAHHAV LLTDVIGTEA 

       370        380        390        400        410        420 
YKPEDIQPPA EDAPQLLHNM WQSWVEVSGK ADQRALIEIF HDCQSDLTEV HSLFAVGQVG 

       430        440        450        460        470        480 
LAERAWAEQV NLRVCYELQG SMSAKYRFHR PIIDELNEKL ADKFFVNFSL FQSLPDAWGI 

       490        500        510        520        530        540 
DQVFPVMPLS GLDKAPESRA VMLDITCDSD GTIDQYVDGQ GIETTLPVPA WTQESPYLIG 

       550        560        570        580        590        600 
FFLVGAYQEI LGDMHNLFGD TNSAVVRLDE DARTNVESVL AGDTVADVLR YVNLDAVSFM 

       610        620        630 
RTYEELVNKH IAEDERANIL EELQLGLKGY TYLEDFS 

« Hide

References

[1]"Complete sequence of Shewanella halifaxensis HAW-EB4."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Kim E., Zhao J.-S., Richardson P.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HAW-EB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000931 Genomic DNA. Translation: ABZ76368.1.
RefSeqYP_001674027.1. NC_010334.1.

3D structure databases

ProteinModelPortalB0TQX3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING458817.Shal_1803.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABZ76368; ABZ76368; Shal_1803.
GeneID5902856.
KEGGshl:Shal_1803.
PATRIC23506281. VBISheHal24697_1891.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1166.
HOGENOMHOG000029191.
KOK01585.
OMAMIHFHIG.
OrthoDBEOG676Z0R.
ProtClustDBPRK05354.

Enzyme and pathway databases

BioCycSHAL458817:GH1X-1862-MONOMER.
UniPathwayUPA00186; UER00284.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
TIGRFAMsTIGR01273. speA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSPEA_SHEHH
AccessionPrimary (citable) accession number: B0TQX3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways