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Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.UniRule annotation

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.UniRule annotation

Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyribose-phosphate aldolase (deoC)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei102Proton donor/acceptorUniRule annotation1
Active sitei166Schiff-base intermediate with acetaldehydeUniRule annotation1
Active sitei198Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandSchiff base

Enzyme and pathway databases

BioCyciSHAL458817:G1GB1-3279-MONOMER
UniPathwayiUPA00002; UER00468

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolaseUniRule annotation (EC:4.1.2.4UniRule annotation)
Short name:
DERAUniRule annotation
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolaseUniRule annotation
PhosphodeoxyriboaldolaseUniRule annotation
Short name:
DeoxyriboaldolaseUniRule annotation
Gene namesi
Name:deoCUniRule annotation
Ordered Locus Names:Shal_3136
OrganismiShewanella halifaxensis (strain HAW-EB4)
Taxonomic identifieri458817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000001317 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000824191 – 257Deoxyribose-phosphate aldolaseAdd BLAST257

Interactioni

Protein-protein interaction databases

STRINGi458817.Shal_3136

Structurei

Secondary structure

1257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 13Combined sources12
Beta strandi15 – 18Combined sources4
Helixi26 – 36Combined sources11
Beta strandi44 – 47Combined sources4
Helixi50 – 52Combined sources3
Helixi53 – 62Combined sources10
Beta strandi68 – 75Combined sources8
Turni76 – 78Combined sources3
Helixi83 – 96Combined sources14
Beta strandi99 – 104Combined sources6
Helixi107 – 111Combined sources5
Helixi116 – 129Combined sources14
Turni130 – 132Combined sources3
Beta strandi134 – 138Combined sources5
Helixi141 – 144Combined sources4
Helixi147 – 159Combined sources13
Beta strandi163 – 166Combined sources4
Beta strandi170 – 173Combined sources4
Helixi178 – 191Combined sources14
Beta strandi195 – 198Combined sources4
Helixi206 – 220Combined sources15
Turni227 – 229Combined sources3
Beta strandi232 – 237Combined sources6
Helixi238 – 244Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5C6MX-ray1.76A/B/C/D1-257[»]
ProteinModelPortaliB0TQ91
SMRiB0TQ91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105FCI Bacteria
COG0274 LUCA
HOGENOMiHOG000241644
KOiK01619
OMAiMNACIPP
OrthoDBiPOG091H00TV

Family and domain databases

CDDicd00959 DeoC, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00592 DeoC_type2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011343 DeoC
IPR002915 DeoC/FbaB/lacD_aldolase
IPR023649 DeoC_typeII
PANTHERiPTHR10889 PTHR10889, 1 hit
PfamiView protein in Pfam
PF01791 DeoC, 1 hit
PIRSFiPIRSF001357 DeoC, 1 hit
SMARTiView protein in SMART
SM01133 DeoC, 1 hit
TIGRFAMsiTIGR00126 deoC, 1 hit

Sequencei

Sequence statusi: Complete.

B0TQ91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDLKKAAQQ AISLMDLTTL NDDDTDQKVI ELCHKAKTPA GDTAAICIYP
60 70 80 90 100
RFIPIARKTL NEIGGDDIKI ATVTNFPHGN DDIAIAVLET RAAVAYGADE
110 120 130 140 150
VDVVFPYRAL MEGNETVGFE LVKACKEACG EDTILKVIIE SGVLADPALI
160 170 180 190 200
RKASELSIDA GADFIKTSTG KVAVNATLEA AEIMMTVISE KNPKVGFKPA
210 220 230 240 250
GGVKDAAAAA EFLGVAARLL GDDWATPATF RFGASSLLTN LLHTLELADA

PQGAQGY
Length:257
Mass (Da):27,082
Last modified:April 8, 2008 - v1
Checksum:i40C6A6DAA78C3A79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000931 Genomic DNA Translation: ABZ77683.1
RefSeqiWP_012278208.1, NC_010334.1

Genome annotation databases

EnsemblBacteriaiABZ77683; ABZ77683; Shal_3136
KEGGishl:Shal_3136

Similar proteinsi

Entry informationi

Entry nameiDEOC_SHEHH
AccessioniPrimary (citable) accession number: B0TQ91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

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