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B0TQ90 (TYPH_SHEHH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
Ordered Locus Names:Shal_3135
OrganismShewanella halifaxensis (strain HAW-EB4) [Complete proteome] [HAMAP]
Taxonomic identifier458817 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis By similarity. HAMAP-Rule MF_01628

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01628

Pathway

Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. HAMAP-Rule MF_01628

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01628

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Thymidine phosphorylase HAMAP-Rule MF_01628
PRO_1000088110

Sequences

Sequence LengthMass (Da)Tools
B0TQ90 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 6B668E85D8213783

FASTA44347,020
        10         20         30         40         50         60 
MFLAQEIIRK KRNAEVLSTE EIQFFVNGIT NNTVSEGQIA AFGMAVYFND MNMDERIALT 

        70         80         90        100        110        120 
TAMRDSGTVL DWKSLDLNGP IIDKHSTGGV GDVISLMLGP MAAACGGYVP MISGRGLGHT 

       130        140        150        160        170        180 
GGTLDKFDAI PGYNTEPDSA LFRKVVKEAG VAIIGQTGDL VPADKRFYSI RDNTATVESI 

       190        200        210        220        230        240 
SLITASILSK KLAAGLDALA MDVKVGTGAF MPTYELSEEL ARSITAVANG AGTKTTALLT 

       250        260        270        280        290        300 
DMNQVLASCA GNAVEVKEAV DFMTGAYRNP RLYEVTMGLC AEMLVLGGIA SNEAEARVKL 

       310        320        330        340        350        360 
NAVLDNGKAA EIFGRMVSGL GGPADFVENY SKYLPDSQII RPVYADRAGF ASAMDTRELG 

       370        380        390        400        410        420 
LAVVTLGGGR RKPGDVLDYS VGLSKVCALG DEINADKPIA FIHAQSEGAF AEAEAAVKKA 

       430        440 
IHIGDTKPDK TPEIYRYIRE SDL 

« Hide

References

[1]"Complete sequence of Shewanella halifaxensis HAW-EB4."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Kim E., Zhao J.-S., Richardson P.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HAW-EB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000931 Genomic DNA. Translation: ABZ77682.1.
RefSeqYP_001675341.1. NC_010334.1.

3D structure databases

ProteinModelPortalB0TQ90.
SMRB0TQ90. Positions 1-440.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING458817.Shal_3135.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABZ77682; ABZ77682; Shal_3135.
GeneID5905584.
KEGGshl:Shal_3135.
PATRIC23509161. VBISheHal24697_3288.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0213.
HOGENOMHOG000047313.
KOK00758.
OMADVWRRMI.
OrthoDBEOG61ZTGG.
ProtClustDBPRK05820.

Enzyme and pathway databases

BioCycSHAL458817:GH1X-3235-MONOMER.
UniPathwayUPA00578; UER00638.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_01628. Thymid_phosp.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_SHEHH
AccessionPrimary (citable) accession number: B0TQ90
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways