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B0TQ90

- TYPH_SHEHH

UniProt

B0TQ90 - TYPH_SHEHH

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Protein

Thymidine phosphorylase

Gene

deoA

Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. pyrimidine-nucleoside phosphorylase activity Source: InterPro
  3. thymidine phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyrimidine nucleobase metabolic process Source: InterPro
  2. pyrimidine nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciSHAL458817:GH1X-3235-MONOMER.
UniPathwayiUPA00578; UER00638.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
Alternative name(s):
TdRPaseUniRule annotation
Gene namesi
Name:deoAUniRule annotation
Ordered Locus Names:Shal_3135
OrganismiShewanella halifaxensis (strain HAW-EB4)
Taxonomic identifieri458817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001317: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Thymidine phosphorylasePRO_1000088110Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi458817.Shal_3135.

Structurei

3D structure databases

ProteinModelPortaliB0TQ90.
SMRiB0TQ90. Positions 1-440.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000047313.
KOiK00758.
OMAiSKIIRPV.
OrthoDBiEOG61ZTGG.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_01628. Thymid_phosp.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0TQ90-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFLAQEIIRK KRNAEVLSTE EIQFFVNGIT NNTVSEGQIA AFGMAVYFND
60 70 80 90 100
MNMDERIALT TAMRDSGTVL DWKSLDLNGP IIDKHSTGGV GDVISLMLGP
110 120 130 140 150
MAAACGGYVP MISGRGLGHT GGTLDKFDAI PGYNTEPDSA LFRKVVKEAG
160 170 180 190 200
VAIIGQTGDL VPADKRFYSI RDNTATVESI SLITASILSK KLAAGLDALA
210 220 230 240 250
MDVKVGTGAF MPTYELSEEL ARSITAVANG AGTKTTALLT DMNQVLASCA
260 270 280 290 300
GNAVEVKEAV DFMTGAYRNP RLYEVTMGLC AEMLVLGGIA SNEAEARVKL
310 320 330 340 350
NAVLDNGKAA EIFGRMVSGL GGPADFVENY SKYLPDSQII RPVYADRAGF
360 370 380 390 400
ASAMDTRELG LAVVTLGGGR RKPGDVLDYS VGLSKVCALG DEINADKPIA
410 420 430 440
FIHAQSEGAF AEAEAAVKKA IHIGDTKPDK TPEIYRYIRE SDL
Length:443
Mass (Da):47,020
Last modified:April 8, 2008 - v1
Checksum:i6B668E85D8213783
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000931 Genomic DNA. Translation: ABZ77682.1.
RefSeqiYP_001675341.1. NC_010334.1.

Genome annotation databases

EnsemblBacteriaiABZ77682; ABZ77682; Shal_3135.
GeneIDi5905584.
KEGGishl:Shal_3135.
PATRICi23509161. VBISheHal24697_3288.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000931 Genomic DNA. Translation: ABZ77682.1 .
RefSeqi YP_001675341.1. NC_010334.1.

3D structure databases

ProteinModelPortali B0TQ90.
SMRi B0TQ90. Positions 1-440.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 458817.Shal_3135.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ77682 ; ABZ77682 ; Shal_3135 .
GeneIDi 5905584.
KEGGi shl:Shal_3135.
PATRICi 23509161. VBISheHal24697_3288.

Phylogenomic databases

eggNOGi COG0213.
HOGENOMi HOG000047313.
KOi K00758.
OMAi SKIIRPV.
OrthoDBi EOG61ZTGG.

Enzyme and pathway databases

UniPathwayi UPA00578 ; UER00638 .
BioCyci SHAL458817:GH1X-3235-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPi MF_01628. Thymid_phosp.
InterProi IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB4.

Entry informationi

Entry nameiTYPH_SHEHH
AccessioniPrimary (citable) accession number: B0TQ90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: October 1, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3