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B0TP70

- LPXB_SHEHH

UniProt

B0TP70 - LPXB_SHEHH

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciSHAL458817:GH1X-3068-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
    Gene namesi
    Name:lpxBUniRule annotation
    Ordered Locus Names:Shal_2968
    OrganismiShewanella halifaxensis (strain HAW-EB4)
    Taxonomic identifieri458817 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000001317: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 383383Lipid-A-disaccharide synthasePRO_1000080284Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi458817.Shal_2968.

    Structurei

    3D structure databases

    ProteinModelPortaliB0TP70.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0TP70-1 [UniParc]FASTAAdd to Basket

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    MSSNNPHVFA MVAGEISGDI LGAGLIKALK TRYPDAKFVG IGGPRMEALG    50
    FESIFSYEEL AVMGIVEVLS RLPRLLKVRA TLIDELVKIN PDCFIGIDAP 100
    DFNIGLELKL KNRGIKTVHY VSPSVWAWRP KRIFKIAKAT DMVLSLLPFE 150
    KAFYDKHQVP CTFVGHTLAD DIELESDKAQ ARELLGLDKE AEYLAILPGS 200
    RGGELKMLAE PFVKAASLIK QRYPDIKFVT PLVNQKRRDQ FEQALREHAP 250
    DLEIDLVEGQ SREVMAAADC ILLASGTATL EAMLVKRPMV VAYRVSPITY 300
    RIAKGMMLTK RYSLPNLLAD DDVVEELIQA DCTPEKIATA VATQLDNDFS 350
    PMYDRFMQMH KSLRCDASAR AADAVIKLVE DKV 383
    Length:383
    Mass (Da):42,598
    Last modified:April 8, 2008 - v1
    Checksum:i4E35DC45BA123596
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000931 Genomic DNA. Translation: ABZ77517.1.
    RefSeqiYP_001675176.1. NC_010334.1.

    Genome annotation databases

    EnsemblBacteriaiABZ77517; ABZ77517; Shal_2968.
    GeneIDi5906834.
    KEGGishl:Shal_2968.
    PATRICi23508811. VBISheHal24697_3113.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000931 Genomic DNA. Translation: ABZ77517.1 .
    RefSeqi YP_001675176.1. NC_010334.1.

    3D structure databases

    ProteinModelPortali B0TP70.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 458817.Shal_2968.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABZ77517 ; ABZ77517 ; Shal_2968 .
    GeneIDi 5906834.
    KEGGi shl:Shal_2968.
    PATRICi 23508811. VBISheHal24697_3113.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci SHAL458817:GH1X-3068-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HAW-EB4.

    Entry informationi

    Entry nameiLPXB_SHEHH
    AccessioniPrimary (citable) accession number: B0TP70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3