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B0TP70

- LPXB_SHEHH

UniProt

B0TP70 - LPXB_SHEHH

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSHAL458817:GH1X-3068-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:Shal_2968
OrganismiShewanella halifaxensis (strain HAW-EB4)
Taxonomic identifieri458817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001317: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Lipid-A-disaccharide synthasePRO_1000080284Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi458817.Shal_2968.

Structurei

3D structure databases

ProteinModelPortaliB0TP70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B0TP70 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSNNPHVFA MVAGEISGDI LGAGLIKALK TRYPDAKFVG IGGPRMEALG
60 70 80 90 100
FESIFSYEEL AVMGIVEVLS RLPRLLKVRA TLIDELVKIN PDCFIGIDAP
110 120 130 140 150
DFNIGLELKL KNRGIKTVHY VSPSVWAWRP KRIFKIAKAT DMVLSLLPFE
160 170 180 190 200
KAFYDKHQVP CTFVGHTLAD DIELESDKAQ ARELLGLDKE AEYLAILPGS
210 220 230 240 250
RGGELKMLAE PFVKAASLIK QRYPDIKFVT PLVNQKRRDQ FEQALREHAP
260 270 280 290 300
DLEIDLVEGQ SREVMAAADC ILLASGTATL EAMLVKRPMV VAYRVSPITY
310 320 330 340 350
RIAKGMMLTK RYSLPNLLAD DDVVEELIQA DCTPEKIATA VATQLDNDFS
360 370 380
PMYDRFMQMH KSLRCDASAR AADAVIKLVE DKV
Length:383
Mass (Da):42,598
Last modified:April 8, 2008 - v1
Checksum:i4E35DC45BA123596
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000931 Genomic DNA. Translation: ABZ77517.1.
RefSeqiWP_012278044.1. NC_010334.1.
YP_001675176.1. NC_010334.1.

Genome annotation databases

EnsemblBacteriaiABZ77517; ABZ77517; Shal_2968.
GeneIDi5906834.
KEGGishl:Shal_2968.
PATRICi23508811. VBISheHal24697_3113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000931 Genomic DNA. Translation: ABZ77517.1 .
RefSeqi WP_012278044.1. NC_010334.1.
YP_001675176.1. NC_010334.1.

3D structure databases

ProteinModelPortali B0TP70.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 458817.Shal_2968.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ77517 ; ABZ77517 ; Shal_2968 .
GeneIDi 5906834.
KEGGi shl:Shal_2968.
PATRICi 23508811. VBISheHal24697_3113.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci SHAL458817:GH1X-3068-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB4.

Entry informationi

Entry nameiLPXB_SHEHH
AccessioniPrimary (citable) accession number: B0TP70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3