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B0TP70

- LPXB_SHEHH

UniProt

B0TP70 - LPXB_SHEHH

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Protein
Lipid-A-disaccharide synthase
Gene
lpxB, Shal_2968
Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciSHAL458817:GH1X-3068-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:Shal_2968
OrganismiShewanella halifaxensis (strain HAW-EB4)
Taxonomic identifieri458817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001317: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Lipid-A-disaccharide synthaseUniRule annotation
PRO_1000080284Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi458817.Shal_2968.

Structurei

3D structure databases

ProteinModelPortaliB0TP70.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

B0TP70-1 [UniParc]FASTAAdd to Basket

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MSSNNPHVFA MVAGEISGDI LGAGLIKALK TRYPDAKFVG IGGPRMEALG    50
FESIFSYEEL AVMGIVEVLS RLPRLLKVRA TLIDELVKIN PDCFIGIDAP 100
DFNIGLELKL KNRGIKTVHY VSPSVWAWRP KRIFKIAKAT DMVLSLLPFE 150
KAFYDKHQVP CTFVGHTLAD DIELESDKAQ ARELLGLDKE AEYLAILPGS 200
RGGELKMLAE PFVKAASLIK QRYPDIKFVT PLVNQKRRDQ FEQALREHAP 250
DLEIDLVEGQ SREVMAAADC ILLASGTATL EAMLVKRPMV VAYRVSPITY 300
RIAKGMMLTK RYSLPNLLAD DDVVEELIQA DCTPEKIATA VATQLDNDFS 350
PMYDRFMQMH KSLRCDASAR AADAVIKLVE DKV 383
Length:383
Mass (Da):42,598
Last modified:April 8, 2008 - v1
Checksum:i4E35DC45BA123596
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000931 Genomic DNA. Translation: ABZ77517.1.
RefSeqiYP_001675176.1. NC_010334.1.

Genome annotation databases

EnsemblBacteriaiABZ77517; ABZ77517; Shal_2968.
GeneIDi5906834.
KEGGishl:Shal_2968.
PATRICi23508811. VBISheHal24697_3113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000931 Genomic DNA. Translation: ABZ77517.1 .
RefSeqi YP_001675176.1. NC_010334.1.

3D structure databases

ProteinModelPortali B0TP70.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 458817.Shal_2968.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ77517 ; ABZ77517 ; Shal_2968 .
GeneIDi 5906834.
KEGGi shl:Shal_2968.
PATRICi 23508811. VBISheHal24697_3113.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci SHAL458817:GH1X-3068-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB4.

Entry informationi

Entry nameiLPXB_SHEHH
AccessioniPrimary (citable) accession number: B0TP70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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