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B0TLB8 (B0TLB8_SHEHH) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-ketoacyl-CoA thiolase HAMAP MF_01620
EC=2.3.1.16 HAMAP MF_01620
Alternative name(s):
Acetyl-CoA acyltransferase HAMAP MF_01620
Beta-ketothiolase HAMAP MF_01620
Fatty acid oxidation complex subunit beta HAMAP MF_01620
Gene names
Name:fadA HAMAP MF_01620
Ordered Locus Names:Shal_0015
OrganismShewanella halifaxensis (strain HAW-EB4) [Complete proteome] [HAMAP] EMBL ABZ74591.1
Taxonomic identifier458817 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Alteromonadales › Shewanellaceae › Shewanella

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed By similarity. HAMAP MF_01620

Catalytic activity

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. HAMAP MF_01620 SAAS SAAS020613

Pathway

Lipid metabolism; fatty acid beta-oxidation. HAMAP MF_01620 SAAS SAAS020613

Subunit structure

Heterotetramer of two alpha chains (fadB) and two beta chains (fadA) By similarity. HAMAP MF_01620 SAAS SAAS020613

Subcellular location

Cytoplasm By similarity HAMAP MF_01620.

Sequence similarities

Belongs to the thiolase family. HAMAP MF_01620

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site911Acyl-thioester intermediate By similarity HAMAP MF_01620
Active site3431Proton acceptor By similarity HAMAP MF_01620
Active site3731Proton acceptor By similarity HAMAP MF_01620

Sequences

Sequence LengthMass (Da)Tools
B0TLB8 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 82D6FA4153EF6A93

FASTA38740,813
        10         20         30         40         50         60 
MKNAVIVDCI RTPMGRSKAG VFRNVRAETL SAELMKSLLE RNPKLDPNTI EDVMWGCVQQ 

        70         80         90        100        110        120 
TLEQGFNIAR NAALLAGIPK QVGAVTVNRL CGSSMDALHQ AARAIMTGQG DTFIVGGVEH 

       130        140        150        160        170        180 
MGHVPMNHGV DFHPGLANNV AKGSAMMGLT AEMLGKMHGI TREQQDAFAV RSHQRAHAAT 

       190        200        210        220        230        240 
VEGRFANEIV AIEGHDADGA LIRVDHDEVI RPETSMESLS GLRPAFDPAN GTVTAGTSSA 

       250        260        270        280        290        300 
LSDGASAMLV MEEEKAKALG LPIRARIRSM AIAGCDAAIM GYGPVPATQK ALKRAGLTVD 

       310        320        330        340        350        360 
DLDVIELNEA FAAQSLPCVK DLGLMDVVDE KVNLNGGAIA LGHPLGCSGT RISTTLINLM 

       370        380 
EAKDAKYGLA TMCIGLGQGI ATIFERP

« Hide

References

[1]"Complete sequence of Shewanella halifaxensis HAW-EB4."
Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Sims D., Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Kim E., Zhao J.-S., Richardson P.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HAW-EB4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000931 Genomic DNA. Translation: ABZ74591.1.
RefSeqYP_001672250.1. NC_010334.1.

3D structure databases

ProteinModelPortalB0TLB8.
SMRB0TLB8. Positions 2-386.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0TLB8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5903922.
GenomeReviewsGene locus Shal_0015 in contig CP000931_GR.
KEGGshl:Shal_0015.
PATRIC23502408. VBISheHal24697_0016.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG370930.
OMAAIDDIYW.
ProtClustDBPRK08947.

Enzyme and pathway databases

BioCycSHAL458817:SHAL_0015-MONOMER.

Family and domain databases

HAMAPMF_01620. FadA.
[Tree]
InterProIPR012805. FadA.
IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 4 hits.
KOK00632.
PANTHERPTHR18919:SF35. PTHR18919:SF35. 1 hit.
PTHR18919. Thiolase. 1 hit.
PfamPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMSSF53901. Thiolase-like. 2 hits.
TIGRFAMsTIGR01930. AcCoA-C-Actrans. 1 hit.
TIGR02445. FadA. 1 hit.
PROSITEPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB0TLB8_SHEHH
AccessionPrimary (citable) accession number: B0TLB8
Entry history
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info