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B0TL85

- ASSY_SHEHH

UniProt

B0TL85 - ASSY_SHEHH

Protein

Argininosuccinate synthase

Gene

argG

Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei48 – 481ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei100 – 1001CitrullineUniRule annotation
    Binding sitei105 – 1051CitrullineUniRule annotation
    Binding sitei130 – 1301ATP; via amide nitrogenUniRule annotation
    Binding sitei132 – 1321AspartateUniRule annotation
    Binding sitei136 – 1361AspartateUniRule annotation
    Binding sitei136 – 1361CitrullineUniRule annotation
    Binding sitei137 – 1371AspartateUniRule annotation
    Binding sitei140 – 1401CitrullineUniRule annotation
    Binding sitei189 – 1891CitrullineUniRule annotation
    Binding sitei198 – 1981CitrullineUniRule annotation
    Binding sitei274 – 2741CitrullineUniRule annotation
    Binding sitei286 – 2861CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi20 – 289ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSHAL458817:GH1X-4223-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:Shal_4090
    OrganismiShewanella halifaxensis (strain HAW-EB4)
    Taxonomic identifieri458817 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
    ProteomesiUP000001317: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 412412Argininosuccinate synthasePRO_1000073830Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi458817.Shal_4090.

    Structurei

    3D structure databases

    ProteinModelPortaliB0TL85.
    SMRiB0TL85. Positions 16-411.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiPECEYIR.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0TL85-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNENSAVTK HAGVKKVVLA YSGGLDTSAI IPWLKETYDD CEIIAFCADV    50
    GQGDAELEGL YEKAIASGAS ECHIVDLKEE LVADYIYPTI ATGAIYEGTY 100
    LLGTSMARPI IAKAQVEVAR KVGADAVCHG CTGKGNDQVR FEGCFAALAP 150
    DLKVIAPWRE WEMVSREDLL DYLAERNIAT SASATKIYSR DANAWHISHE 200
    GGELEDPWNE PSKGVWTMTV APEDAPNQPE YVALELEQGK ITKVNGEALS 250
    PYNALMLLNE VAGAHGVGRI DITENRLVGM KSRGCYETPG GTVMFAALRA 300
    IEELVLDKTS REWREQIGTK MAHLVYDGRW FTPLCESLLG ASKPLADLIN 350
    GEVVVKLYKG QASVVKKRSP NSLYSEAFAT FGADDVYNQK DAEGFIRLYS 400
    LSSRIRALNN QK 412
    Length:412
    Mass (Da):44,998
    Last modified:April 8, 2008 - v1
    Checksum:iCCC149FE4CFB363D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000931 Genomic DNA. Translation: ABZ78630.1.
    RefSeqiYP_001676289.1. NC_010334.1.

    Genome annotation databases

    EnsemblBacteriaiABZ78630; ABZ78630; Shal_4090.
    GeneIDi5902889.
    KEGGishl:Shal_4090.
    PATRICi23511220. VBISheHal24697_4283.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000931 Genomic DNA. Translation: ABZ78630.1 .
    RefSeqi YP_001676289.1. NC_010334.1.

    3D structure databases

    ProteinModelPortali B0TL85.
    SMRi B0TL85. Positions 16-411.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 458817.Shal_4090.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABZ78630 ; ABZ78630 ; Shal_4090 .
    GeneIDi 5902889.
    KEGGi shl:Shal_4090.
    PATRICi 23511220. VBISheHal24697_4283.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi PECEYIR.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci SHAL458817:GH1X-4223-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HAW-EB4.

    Entry informationi

    Entry nameiASSY_SHEHH
    AccessioniPrimary (citable) accession number: B0TL85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3