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B0TL85

- ASSY_SHEHH

UniProt

B0TL85 - ASSY_SHEHH

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei100 – 1001CitrullineUniRule annotation
Binding sitei105 – 1051CitrullineUniRule annotation
Binding sitei130 – 1301ATP; via amide nitrogenUniRule annotation
Binding sitei132 – 1321AspartateUniRule annotation
Binding sitei136 – 1361AspartateUniRule annotation
Binding sitei136 – 1361CitrullineUniRule annotation
Binding sitei137 – 1371AspartateUniRule annotation
Binding sitei140 – 1401CitrullineUniRule annotation
Binding sitei189 – 1891CitrullineUniRule annotation
Binding sitei198 – 1981CitrullineUniRule annotation
Binding sitei274 – 2741CitrullineUniRule annotation
Binding sitei286 – 2861CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 289ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSHAL458817:GH1X-4223-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Shal_4090
OrganismiShewanella halifaxensis (strain HAW-EB4)
Taxonomic identifieri458817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001317: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 412412Argininosuccinate synthasePRO_1000073830Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi458817.Shal_4090.

Structurei

3D structure databases

ProteinModelPortaliB0TL85.
SMRiB0TL85. Positions 16-411.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiPECEYIR.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0TL85-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNENSAVTK HAGVKKVVLA YSGGLDTSAI IPWLKETYDD CEIIAFCADV
60 70 80 90 100
GQGDAELEGL YEKAIASGAS ECHIVDLKEE LVADYIYPTI ATGAIYEGTY
110 120 130 140 150
LLGTSMARPI IAKAQVEVAR KVGADAVCHG CTGKGNDQVR FEGCFAALAP
160 170 180 190 200
DLKVIAPWRE WEMVSREDLL DYLAERNIAT SASATKIYSR DANAWHISHE
210 220 230 240 250
GGELEDPWNE PSKGVWTMTV APEDAPNQPE YVALELEQGK ITKVNGEALS
260 270 280 290 300
PYNALMLLNE VAGAHGVGRI DITENRLVGM KSRGCYETPG GTVMFAALRA
310 320 330 340 350
IEELVLDKTS REWREQIGTK MAHLVYDGRW FTPLCESLLG ASKPLADLIN
360 370 380 390 400
GEVVVKLYKG QASVVKKRSP NSLYSEAFAT FGADDVYNQK DAEGFIRLYS
410
LSSRIRALNN QK
Length:412
Mass (Da):44,998
Last modified:April 8, 2008 - v1
Checksum:iCCC149FE4CFB363D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000931 Genomic DNA. Translation: ABZ78630.1.
RefSeqiYP_001676289.1. NC_010334.1.

Genome annotation databases

EnsemblBacteriaiABZ78630; ABZ78630; Shal_4090.
GeneIDi5902889.
KEGGishl:Shal_4090.
PATRICi23511220. VBISheHal24697_4283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000931 Genomic DNA. Translation: ABZ78630.1 .
RefSeqi YP_001676289.1. NC_010334.1.

3D structure databases

ProteinModelPortali B0TL85.
SMRi B0TL85. Positions 16-411.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 458817.Shal_4090.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ78630 ; ABZ78630 ; Shal_4090 .
GeneIDi 5902889.
KEGGi shl:Shal_4090.
PATRICi 23511220. VBISheHal24697_4283.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi PECEYIR.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci SHAL458817:GH1X-4223-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB4.

Entry informationi

Entry nameiASSY_SHEHH
AccessioniPrimary (citable) accession number: B0TL85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: November 26, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3