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Protein

3-ketoacyl-CoA thiolase

Gene

fadI

Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.UniRule annotation

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.UniRule annotation

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei99Acyl-thioester intermediateUniRule annotation1
Active sitei392Proton acceptorUniRule annotation1
Active sitei422Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00659.

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolaseUniRule annotation (EC:2.3.1.16UniRule annotation)
Alternative name(s):
ACSsUniRule annotation
Acetyl-CoA acyltransferaseUniRule annotation
Acyl-CoA ligaseUniRule annotation
Beta-ketothiolaseUniRule annotation
Fatty acid oxidation complex subunit betaUniRule annotation
Gene namesi
Name:fadIUniRule annotation
Ordered Locus Names:Shal_2671
OrganismiShewanella halifaxensis (strain HAW-EB4)
Taxonomic identifieri458817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
Proteomesi
  • UP000001317 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000880681 – 4363-ketoacyl-CoA thiolaseAdd BLAST436

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).UniRule annotation

Protein-protein interaction databases

STRINGi458817.Shal_2671.

Structurei

3D structure databases

ProteinModelPortaliB0TL22.
SMRiB0TL22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHU. Bacteria.
COG0183. LUCA.
HOGENOMiHOG000012240.
KOiK00632.
OMAiMTAFPEP.
OrthoDBiPOG091H065K.

Family and domain databases

CDDicd00751. thiolase. 1 hit.
Gene3Di3.40.47.10. 2 hits.
HAMAPiMF_01618. FadI. 1 hit.
InterProiView protein in InterPro
IPR012806. Ac-CoA_C-AcTrfase_FadI.
IPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
PANTHERiPTHR18919:SF128. PTHR18919:SF128. 1 hit.
PfamiView protein in Pfam
PF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
PIRSFiPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR01930. AcCoA-C-Actrans. 1 hit.
TIGR02446. FadI. 1 hit.
PROSITEiView protein in PROSITE
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

B0TL22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRQQVTNA RGERIAIVSG LRTPFAKQAT AFHGVSALDM GKMVVNELLS
60 70 80 90 100
RSELNPKEIE QLVYGQVVQM PAAPNIAREI VLGTGMDVST DAYSVTRACA
110 120 130 140 150
TSFQSTVNVA ESIMTGNMDI GIAGGADSSS VLPIGVSKKL AHALVDLNKA
160 170 180 190 200
RSFGQKLAIF RRLGLKDLLP VPPAVAEYST GLSMGQTAEQ MAKTYNISRA
210 220 230 240 250
DQDALAHRSH TLATETWNAG KLAEEVMAAH VPPYKSFIDR DNNIRENSTL
260 270 280 290 300
ESYAKLRPAF DRKHGSVTAA NSTPLTDGAS AVLLMSEGRA KALGYTPIGY
310 320 330 340 350
IKSYAFTAID VWQDMLMGPS YATPLALKRA GMELEDLTLI EMHEAFAAQT
360 370 380 390 400
LANMQMFASK KFAEEKLGRN RAIGEIDMSK FNVLGGSLAY GHPFAATGTR
410 420 430
LVTQVCHELK RRGGGTGLAT ACAAGGLGAA MIVEVE
Length:436
Mass (Da):46,592
Last modified:April 8, 2008 - v1
Checksum:i53A8B5D7AA44A042
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000931 Genomic DNA. Translation: ABZ77224.1.
RefSeqiWP_012277752.1. NC_010334.1.

Genome annotation databases

EnsemblBacteriaiABZ77224; ABZ77224; Shal_2671.
KEGGishl:Shal_2671.

Similar proteinsi

Entry informationi

Entry nameiFADI_SHEHH
AccessioniPrimary (citable) accession number: B0TL22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: August 30, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families