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B0TL21

- FADJ_SHEHH

UniProt

B0TL21 - FADJ_SHEHH

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Protein
Fatty acid oxidation complex subunit alpha
Gene
fadJ, Shal_2670
Organism
Shewanella halifaxensis (strain HAW-EB4)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities By similarity.UniRule annotation

Catalytic activityi

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.UniRule annotation
(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.UniRule annotation
(S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei118 – 1181Important for catalytic activity By similarity
Sitei140 – 1401Important for catalytic activity By similarity

GO - Molecular functioni

  1. 3-hydroxyacyl-CoA dehydrogenase activity Source: UniProtKB-HAMAP
  2. 3-hydroxybutyryl-CoA epimerase activity Source: UniProtKB-HAMAP
  3. NAD binding Source: InterPro
  4. enoyl-CoA hydratase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. fatty acid beta-oxidation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Lyase, Oxidoreductase

Keywords - Biological processi

Fatty acid metabolism, Lipid degradation, Lipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSHAL458817:GH1X-2766-MONOMER.
UniPathwayiUPA00659.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid oxidation complex subunit alpha
Including the following 2 domains:
Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase (EC:4.2.1.17, EC:5.1.2.3)
3-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.35)
Gene namesi
Name:fadJ
Ordered Locus Names:Shal_2670
OrganismiShewanella halifaxensis (strain HAW-EB4)
Taxonomic identifieri458817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesShewanellaceaeShewanella
ProteomesiUP000001317: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 708708Fatty acid oxidation complex subunit alphaUniRule annotation
PRO_1000088063Add
BLAST

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI) By similarity.

Protein-protein interaction databases

STRINGi458817.Shal_2670.

Structurei

3D structure databases

ProteinModelPortaliB0TL21.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 190190Enoyl-CoA hydratase By similarity
Add
BLAST
Regioni310 – 7083993-hydroxyacyl-CoA dehydrogenase By similarity
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.
In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

Phylogenomic databases

eggNOGiCOG1250.
HOGENOMiHOG000261346.
KOiK01782.
OMAiPFRYMDT.
OrthoDBiEOG6M9F0M.

Family and domain databases

Gene3Di1.10.1040.10. 2 hits.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
HAMAPiMF_01617. FadJ.
InterProiIPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR012802. FadJ.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00725. 3HCDH. 2 hits.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR02440. FadJ. 1 hit.

Sequencei

Sequence statusi: Complete.

B0TL21-1 [UniParc]FASTAAdd to Basket

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MDMEKTFNLT RRDDGIAILT MDVPGETMNT LRSEFGPEIS DVLAEIKADT    50
SIKGLVLVSG KKDSFVAGAD ISMLDACETA TDAKQLSQQG HVVFNELESL 100
PIPVVAAING ACLGGGLELA LACHKRVCSL NPKTMMGVPE VQLGLLPGGG 150
GTQRLPRLVG VTTALDMMLT GKQLRPKQAL KMGLVDDAVP ESILLRTAVE 200
MALAGKRPAK KKHQSFFNKV LEGTSAGRNI IFDQAGKQVA KKTQGNYPAP 250
AKIIDCVRQG MTKGMAKGLE VEASHFADLV MSKESGAMRS VFFATTEMKK 300
ETGAGDVEPQ KVNKVMVLGG GLMGGGIASV TTTKAKIPAR VKDISETGLS 350
NALAYAYKLL DKGVKRRHMT PAVRDNLMAL MTTTTEYKGI KDADIVVEAV 400
FEDLALKHQM VKDVERECGE HTIFASNTSS LPIGQIAEAA SRPENVIGLH 450
YFSPVEKMPL VEVIAHEKTS AETIATTVAF AKKQGKTPIV VQDGAGFYVN 500
RILALYMNEA AQLLLEGQSV EHLDKALIKF GFPVGPMTLL DEVGIDVGAK 550
ISPILEKELG ERFKAPTAFD KLLADDRKGR KNGKGFYLYG GKKKAKEVDQ 600
TVYSVLGLKP GVDTEATEVA QRCVVQMLNE AVRCLEESII ACPRDGDIGA 650
IFGIGFPPFL GGPFHYIDTL GAANLVKILE NYQSRYGSRF EPAAKLKQMA 700
EEGTRFFS 708
Length:708
Mass (Da):76,230
Last modified:April 8, 2008 - v1
Checksum:iA0C731D06441039D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000931 Genomic DNA. Translation: ABZ77223.1.
RefSeqiWP_012277751.1. NC_010334.1.
YP_001674882.1. NC_010334.1.

Genome annotation databases

EnsemblBacteriaiABZ77223; ABZ77223; Shal_2670.
GeneIDi5902951.
KEGGishl:Shal_2670.
PATRICi23508199. VBISheHal24697_2810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000931 Genomic DNA. Translation: ABZ77223.1 .
RefSeqi WP_012277751.1. NC_010334.1.
YP_001674882.1. NC_010334.1.

3D structure databases

ProteinModelPortali B0TL21.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 458817.Shal_2670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ77223 ; ABZ77223 ; Shal_2670 .
GeneIDi 5902951.
KEGGi shl:Shal_2670.
PATRICi 23508199. VBISheHal24697_2810.

Phylogenomic databases

eggNOGi COG1250.
HOGENOMi HOG000261346.
KOi K01782.
OMAi PFRYMDT.
OrthoDBi EOG6M9F0M.

Enzyme and pathway databases

UniPathwayi UPA00659 .
BioCyci SHAL458817:GH1X-2766-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 2 hits.
3.40.50.720. 1 hit.
3.90.226.10. 1 hit.
HAMAPi MF_01617. FadJ.
InterProi IPR006176. 3-OHacyl-CoA_DH_NAD-bd.
IPR006108. 3HC_DH_C.
IPR008927. 6-PGluconate_DH_C-like.
IPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR013328. DH_multihelical.
IPR012802. FadJ.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00725. 3HCDH. 2 hits.
PF02737. 3HCDH_N. 1 hit.
PF00378. ECH. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 2 hits.
SSF52096. SSF52096. 1 hit.
TIGRFAMsi TIGR02440. FadJ. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HAW-EB4.

Entry informationi

Entry nameiFADJ_SHEHH
AccessioniPrimary (citable) accession number: B0TL21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: September 3, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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