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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Helmi_20650
ORF Names:HM1_2133
OrganismiHeliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Taxonomic identifieri498761 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesHeliobacteriaceaeHeliobacterium
Proteomesi
  • UP000008550 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000984091 – 316Methionyl-tRNA formyltransferaseAdd BLAST316

Interactioni

Protein-protein interaction databases

STRINGi498761.HM1_2133.

Structurei

3D structure databases

ProteinModelPortaliB0TGS9.
SMRiB0TGS9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni108 – 111Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE. Bacteria.
COG0223. LUCA.
HOGENOMiHOG000261177.
KOiK00604.
OMAiLRIVFMG.
OrthoDBiPOG091H01YM.

Family and domain databases

Gene3Di3.10.25.10. 1 hit.
3.40.50.170. 1 hit.
HAMAPiMF_00182. Formyl_trans. 1 hit.
InterProiView protein in InterPro
IPR005794. Fmt.
IPR005793. Formyl_trans_C.
IPR002376. Formyl_transf_N.
IPR011034. Formyl_transferase_C-like.
IPR001555. GART_AS.
PfamiView protein in Pfam
PF02911. Formyl_trans_C. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
SUPFAMiSSF50486. SSF50486. 1 hit.
SSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00460. fmt. 1 hit.
PROSITEiView protein in PROSITE
PS00373. GART. 1 hit.

Sequencei

Sequence statusi: Complete.

B0TGS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLVFMGTPD FAVPTLEAIV AAGHEVALVV TRPDRPRGRG QKPQPSPVKE
60 70 80 90 100
AALRLGLPVD HPACLDNEFV QKLKDLGVEA GVVVAFGRIL PPRLLDAFPQ
110 120 130 140 150
RWINVHASLL PKYRGAAPIH RAVIDGEKET GITTMLMSEG LDEGDMLLKR
160 170 180 190 200
SLAIGPDDTT GQVHDALAEL GARLLVETLA AMEAGRLQPQ PQDGSQASYA
210 220 230 240 250
PMLARADEQV DWSAPAEAVH NRVRGMNPWP GAFTMDEGKI LKILRGRLRH
260 270 280 290 300
EGLPLPDPTG SAAHPGEILQ IVGDEVAVAT GAGVYWLSEV RPAGGKTMTA
310
GAYARGRRIG PGFRFG
Length:316
Mass (Da):33,843
Last modified:April 8, 2008 - v1
Checksum:iDB468089F1D23410
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000930 Genomic DNA. Translation: ABZ84690.1.
RefSeqiWP_012283190.1. NC_010337.2.

Genome annotation databases

EnsemblBacteriaiABZ84690; ABZ84690; HM1_2133.
KEGGihmo:HM1_2133.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFMT_HELMI
AccessioniPrimary (citable) accession number: B0TGS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: June 7, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families