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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciHMOD498761:G1GB0-1944-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:Helmi_20650
ORF Names:HM1_2133
OrganismiHeliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Taxonomic identifieri498761 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesHeliobacteriaceaeHeliobacterium
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000984091 – 316Methionyl-tRNA formyltransferaseAdd BLAST316

Interactioni

Protein-protein interaction databases

STRINGi498761.HM1_2133

Structurei

3D structure databases

ProteinModelPortaliB0TGS9
SMRiB0TGS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni108 – 111Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
IPR001555 GART_AS
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit
PROSITEiView protein in PROSITE
PS00373 GART, 1 hit

Sequencei

Sequence statusi: Complete.

B0TGS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLVFMGTPD FAVPTLEAIV AAGHEVALVV TRPDRPRGRG QKPQPSPVKE
60 70 80 90 100
AALRLGLPVD HPACLDNEFV QKLKDLGVEA GVVVAFGRIL PPRLLDAFPQ
110 120 130 140 150
RWINVHASLL PKYRGAAPIH RAVIDGEKET GITTMLMSEG LDEGDMLLKR
160 170 180 190 200
SLAIGPDDTT GQVHDALAEL GARLLVETLA AMEAGRLQPQ PQDGSQASYA
210 220 230 240 250
PMLARADEQV DWSAPAEAVH NRVRGMNPWP GAFTMDEGKI LKILRGRLRH
260 270 280 290 300
EGLPLPDPTG SAAHPGEILQ IVGDEVAVAT GAGVYWLSEV RPAGGKTMTA
310
GAYARGRRIG PGFRFG
Length:316
Mass (Da):33,843
Last modified:April 8, 2008 - v1
Checksum:iDB468089F1D23410
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000930 Genomic DNA Translation: ABZ84690.1
RefSeqiWP_012283190.1, NC_010337.2

Genome annotation databases

EnsemblBacteriaiABZ84690; ABZ84690; HM1_2133
KEGGihmo:HM1_2133

Similar proteinsi

Entry informationi

Entry nameiFMT_HELMI
AccessioniPrimary (citable) accession number: B0TGS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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