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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfk), ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei308UniRule annotation1
Active sitei422UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciHMOD498761:G1GB0-613-MONOMER
UniPathwayiUPA00109; UER00181
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:Helmi_06520
ORF Names:HM1_1300
OrganismiHeliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Taxonomic identifieri498761 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesHeliobacteriaceaeHeliobacterium
Proteomesi
  • UP000008550 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001257291 – 447Glucose-6-phosphate isomeraseAdd BLAST447

Proteomic databases

PRIDEiB0TGL6

Interactioni

Protein-protein interaction databases

STRINGi498761.HM1_1300

Structurei

3D structure databases

ProteinModelPortaliB0TGL6
SMRiB0TGL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYV Bacteria
COG0166 LUCA
HOGENOMiHOG000100403
KOiK01810
OMAiSFIIPDD
OrthoDBiPOG091H0EIM

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 2 hits
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

B0TGL6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLRLDLAY ATVESAISTM EDPIRQAHDL LHNRTGAGSE FTGWLQLPKT
60 70 80 90 100
YDRAEFARII DAADRIRASS DVLLVIGIGG SYLGARAAID MLSHSFHNQL
110 120 130 140 150
PRSRRPGCAV LFAGHNISSA YLSDLFDILD GKDVSVNVIS KSGTTTEPAI
160 170 180 190 200
AFRLIRRWME KKYSPDEVRR RIFATTDRAK GALKRLADEQ GYETFVVPDD
210 220 230 240 250
VGGRFSVLTT VGLLPIAAAG IDITALLAGA RDAMAEYANP SLATNACYRY
260 270 280 290 300
AAARNLLYRQ GKQVELFVAY EPSLQHLAEW WKQLYGESEG KEGKGIFPAS
310 320 330 340 350
VLFSTDLHSM GQYIQEGQRM LMETVVRFDK PRRELTIPPA EDDSDGLNFL
360 370 380 390 400
AGKTVDFVNQ KAFAGTLLAH VDGQVPNMII SVPEQNAYHL GQLFYFFEKA
410 420 430 440
CGVSGYLLGV NPFDQPGVES YKRNMFALLG KPGFEKEKAA LEARLPR
Length:447
Mass (Da):49,388
Last modified:April 8, 2008 - v1
Checksum:i6BD8C746225ACD06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000930 Genomic DNA Translation: ABZ83277.1
RefSeqiWP_012281811.1, NC_010337.2

Genome annotation databases

EnsemblBacteriaiABZ83277; ABZ83277; HM1_1300
KEGGihmo:HM1_1300

Similar proteinsi

Entry informationi

Entry nameiG6PI_HELMI
AccessioniPrimary (citable) accession number: B0TGL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: February 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome