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B0TEJ8

- NADK_HELMI

UniProt

B0TEJ8 - NADK_HELMI

Protein

NAD kinase

Gene

nadK

Organism
Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei67 – 671Proton acceptorUniRule annotation
    Binding sitei152 – 1521NADUniRule annotation
    Binding sitei171 – 1711NADUniRule annotation
    Binding sitei241 – 2411NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi67 – 682NADUniRule annotation
    Nucleotide bindingi141 – 1422NADUniRule annotation
    Nucleotide bindingi182 – 1876NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHMOD498761:GI46-485-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:Helmi_04670
    ORF Names:HM1_0298
    OrganismiHeliobacterium modesticaldum (strain ATCC 51547 / Ice1)
    Taxonomic identifieri498761 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesHeliobacteriaceaeHeliobacterium
    ProteomesiUP000008550: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283NAD kinasePRO_1000120865Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi498761.HM1_0298.

    Structurei

    3D structure databases

    ProteinModelPortaliB0TEJ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiRWEALCL.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0TEJ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPTVGVVLND DKPQALEVAR RMADWLSQRE VPMGIPLTRV AELVHSPSPE    50
    LRDRLRQLDL IVVLGGDGTL LNTARLAAPH GIPVVGVNLG RLGFLTEVEV 100
    SDLFPALERI IAGDYRIEER MMLEARLIRD GLEQPSYFAL NDVVVTKGDH 150
    PRMIRVEAAV GDEVVWTYSA DGLIVSSPTG STAYSLSAGG PIVSPELHAL 200
    LLTPISPHAL DARPLVIPQD QAVRLTVISS HSHAVVTVDG QPGQPMVCGD 250
    SVLVRKASVA CRLIRLGERT FFRILREKMQ QGR 283
    Length:283
    Mass (Da):30,816
    Last modified:April 8, 2008 - v1
    Checksum:i1E5821D1B760FFA5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000930 Genomic DNA. Translation: ABZ82917.1.
    RefSeqiYP_001678928.1. NC_010337.2.

    Genome annotation databases

    EnsemblBacteriaiABZ82917; ABZ82917; HM1_0298.
    GeneIDi5910006.
    KEGGihmo:HM1_0298.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000930 Genomic DNA. Translation: ABZ82917.1 .
    RefSeqi YP_001678928.1. NC_010337.2.

    3D structure databases

    ProteinModelPortali B0TEJ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 498761.HM1_0298.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABZ82917 ; ABZ82917 ; HM1_0298 .
    GeneIDi 5910006.
    KEGGi hmo:HM1_0298.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi RWEALCL.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci HMOD498761:GI46-485-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Heliobacterium modesticaldum, a phototrophic representative of the Firmicutes containing the simplest photosynthetic apparatus."
      Sattley W.M., Madigan M.T., Swingley W.D., Cheung P.C., Clocksin K.M., Conrad A.L., Dejesa L.C., Honchak B.M., Jung D.O., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Page L.E., Taylor H.L., Wang Z.T., Raymond J., Chen M., Blankenship R.E., Touchman J.W.
      J. Bacteriol. 190:4687-4696(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51547 / Ice1.

    Entry informationi

    Entry nameiNADK_HELMI
    AccessioniPrimary (citable) accession number: B0TEJ8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3