nadD

Functionⁱ

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).UniRule annotation

Catalytic activityⁱ

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD⁺.UniRule annotationSAAS annotation

Pathwayⁱ: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:

Probable nicotinate-nucleotide adenylyltransferase (nadD)

This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
nicotinate-nucleotide adenylyltransferase activity Source: UniProtKB-UniRule

Complete GO annotation...

GO - Biological processⁱ

NAD biosynthetic process Source: UniProtKB-UniRule

Complete GO annotation...

Keywordsⁱ

Molecular function	NucleotidyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological process	Pyridine nucleotide biosynthesisUniRule annotationSAAS annotation
Ligand	ATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayⁱ	UPA00253; UER00332.

UniPathwayⁱ

UPA00253; UER00332.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable nicotinate-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.18UniRule annotation) Alternative name(s): Deamido-NAD(+) diphosphorylaseUniRule annotation Deamido-NAD(+) pyrophosphorylaseUniRule annotation Nicotinate mononucleotide adenylyltransferaseUniRule annotation Short name: NaMN adenylyltransferaseUniRule annotation
Gene namesⁱ	Name:nadDUniRule annotationImported ORF Names:HM1_2701Imported
Organismⁱ	Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)Imported
Taxonomic identifierⁱ	498761 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Terrabacteria group › Firmicutes › Clostridia › Clostridiales › Heliobacteriaceae › Heliobacterium › Heliobacterium modesticaldum
Proteomesⁱ	UP000008550 Componentⁱ: Chromosome

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	498761.HM1_2701.

STRINGⁱ

498761.HM1_2701.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B0TBV7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	6 – 174	CTP_transf_likeInterPro annotationAdd BLAST		169

Sequence similaritiesⁱ

Belongs to the NadD family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	ENOG4108Z1W. Bacteria. COG1057. LUCA.
HOGENOMⁱ	HOG000262779.
KEGG Orthology (KO) More...KOⁱ	K00969.
OMAⁱ	IHIGHLI.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H028Y.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02165. NMNAT. 1 hit.
Gene3Dⁱ	3.40.50.620. 1 hit.
HAMAPⁱ	MF_00244. NaMN_adenylyltr. 1 hit.
InterProⁱ	View protein in InterPro IPR004821. Cyt_trans-like. IPR005248. NadD/NMNAT. IPR014729. Rossmann-like_a/b/a_fold.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01467. CTP_transf_like. 1 hit.
TIGRFAMsⁱ	TIGR00125. cyt_tran_rel. 1 hit. TIGR00482. TIGR00482. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B0TBV7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVRVGIMGGT FDPVHYGHLV TAEAAADLFD LSVVVFVPSG RPPHKQHQDV 
        60         70         80         90        100
TDPWERYRLT ELATCSNPRF RMSDVEVIRP GYSYTIDTVR AFRREYGEQA 
       110        120        130        140        150
EFFFITGADA ILEIMTWRQI DQLMAECRFI AAYRPGYGRD HLRKAVARME 
       160        170        180        190        200
AFSGRIHLVE VPALAISSTD IRRRLYEGRS VKYLLPEPVL HRIMETGVYH 
       210
LASRHRQPRE

Length:210

Mass (Da):24,237

Last modified:April 8, 2008 - v1

Checksum:ⁱ17192F8591BEE002

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000930 Genomic DNA. Translation: ABZ85230.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_012283715.1. NC_010337.2.

Genome annotation databases

EnsemblBacteriaⁱ	ABZ85230; ABZ85230; HM1_2701.
KEGGⁱ	hmo:HM1_2701.

Similar proteinsⁱ

50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
B0TBV7	A3DEU4 W4V955 A0A1E3BVN1 A0A1F3B1T5 A0A1W1UGU4 UPI0009FD4683 A0A1F2UTL6 UPI0003B3D231 W1TTC0 A0A134BQD8 +24	Clostridium thermocellum (strain ATCC 27405 / DSM 1237 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) (Ruminiclostridium thermocellum) [Clostridium] straminisolvens JCM 21531 Clostridium sp. Bc-iso-3 Heliobacterium modesticaldum (strain ATCC 51547 / Ice1) Armatimonadetes bacterium RBG_19FT_COMBO_69_19 Desulfonispora thiosulfatigenes DSM 11270 Desulfonispora thiosulfatigenes Actinobacteria bacterium GWC2_53_9 Varibaculum cambriense Varibaculum cambriense DORA_20 And more	206	UniRef50_A3DEU4	Cluster: Probable nicotinate-nucleotide adenylyltransferase	35

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000930 Genomic DNA. Translation: ABZ85230.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_012283715.1. NC_010337.2.

3D structure databases

ProteinModelPortalⁱ	B0TBV7.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	498761.HM1_2701.

STRINGⁱ

498761.HM1_2701.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABZ85230; ABZ85230; HM1_2701.
KEGGⁱ	hmo:HM1_2701.

Phylogenomic databases

eggNOGⁱ	ENOG4108Z1W. Bacteria. COG1057. LUCA.
HOGENOMⁱ	HOG000262779.
KEGG Orthology (KO) More...KOⁱ	K00969.
OMAⁱ	IHIGHLI.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H028Y.

Enzyme and pathway databases

UniPathwayⁱ	UPA00253; UER00332.

UniPathwayⁱ

UPA00253; UER00332.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02165. NMNAT. 1 hit.
Gene3Dⁱ	3.40.50.620. 1 hit.
HAMAPⁱ	MF_00244. NaMN_adenylyltr. 1 hit.
InterProⁱ	View protein in InterPro IPR004821. Cyt_trans-like. IPR005248. NadD/NMNAT. IPR014729. Rossmann-like_a/b/a_fold.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01467. CTP_transf_like. 1 hit.
TIGRFAMsⁱ	TIGR00125. cyt_tran_rel. 1 hit. TIGR00482. TIGR00482. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B0TBV7_HELMI
Accessionⁱ	B0TBV7Primary (citable) accession number: B0TBV7
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 8, 2008
	Last sequence update:	April 8, 2008
	Last modified:	September 27, 2017
	This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - B0TBV7 (B0TBV7_HELMI)

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Probable nicotinate-nucleotide adenylyltransferase

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: NAD(+) biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Interactionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B0TBV7 (B0TBV7_HELMI)

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Probable nicotinate-nucleotide adenylyltransferase

nadD

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: NAD(+) biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

Pathwayⁱ: NAD(+) biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ