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UniProtKB - B0TBV7 (B0TBV7_HELMI)

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Protein

Probable nicotinate-nucleotide adenylyltransferase

Gene

nadD

Organism
Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).UniRule annotationSAAS annotation

Catalytic activityi

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.UniRule annotationSAAS annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable nicotinate-nucleotide adenylyltransferase (nadD)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processPyridine nucleotide biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00332.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.18UniRule annotation)
Alternative name(s):
Deamido-NAD(+) diphosphorylaseUniRule annotation
Deamido-NAD(+) pyrophosphorylaseUniRule annotation
Nicotinate mononucleotide adenylyltransferaseUniRule annotation
Short name:
NaMN adenylyltransferaseUniRule annotation
Gene namesi
Name:nadDUniRule annotationImported
ORF Names:HM1_2701Imported
OrganismiHeliobacterium modesticaldum (strain ATCC 51547 / Ice1)Imported
Taxonomic identifieri498761 [NCBI]
Taxonomic lineageiBacteria › Firmicutes › Clostridia › Clostridiales › Heliobacteriaceae › Heliobacterium ›
Proteomesi
  • UP000008550 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi498761.HM1_2701.

Structurei

3D structure databases

ProteinModelPortaliB0TBV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 174CTP_transf_likeInterPro annotationAdd BLAST169

Sequence similaritiesi

Belongs to the NadD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108Z1W. Bacteria.
COG1057. LUCA.
HOGENOMiHOG000262779.
KOiK00969.
OMAiIHIGHLI.
OrthoDBiPOG091H028Y.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr. 1 hit.
InterProiView protein in InterPro
IPR004821. Cyt_trans-like.
IPR005248. NadD/NMNAT.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF01467. CTP_transf_like. 1 hit.
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.

Sequencei

Sequence statusi: Complete.

B0TBV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRVGIMGGT FDPVHYGHLV TAEAAADLFD LSVVVFVPSG RPPHKQHQDV 
        60         70         80         90        100
TDPWERYRLT ELATCSNPRF RMSDVEVIRP GYSYTIDTVR AFRREYGEQA 
       110        120        130        140        150
EFFFITGADA ILEIMTWRQI DQLMAECRFI AAYRPGYGRD HLRKAVARME 
       160        170        180        190        200
AFSGRIHLVE VPALAISSTD IRRRLYEGRS VKYLLPEPVL HRIMETGVYH 
       210
LASRHRQPRE
Length:210
Mass (Da):24,237
Last modified:April 8, 2008 - v1
Checksum:i17192F8591BEE002
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000930 Genomic DNA. Translation: ABZ85230.1.
RefSeqiWP_012283715.1. NC_010337.2.

Genome annotation databases

EnsemblBacteriaiABZ85230; ABZ85230; HM1_2701.
KEGGihmo:HM1_2701.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000930 Genomic DNA. Translation: ABZ85230.1.
RefSeqiWP_012283715.1. NC_010337.2.

3D structure databases

ProteinModelPortaliB0TBV7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi498761.HM1_2701.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABZ85230; ABZ85230; HM1_2701.
KEGGihmo:HM1_2701.

Phylogenomic databases

eggNOGiENOG4108Z1W. Bacteria.
COG1057. LUCA.
HOGENOMiHOG000262779.
KOiK00969.
OMAiIHIGHLI.
OrthoDBiPOG091H028Y.

Enzyme and pathway databases

UniPathwayiUPA00253; UER00332.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr. 1 hit.
InterProiView protein in InterPro
IPR004821. Cyt_trans-like.
IPR005248. NadD/NMNAT.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF01467. CTP_transf_like. 1 hit.
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB0TBV7_HELMI
AccessioniPrimary (citable) accession number: B0TBV7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: June 7, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.