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B0TBV7

- B0TBV7_HELMI

UniProt

B0TBV7 - B0TBV7_HELMI

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Protein

Probable nicotinate-nucleotide adenylyltransferase

Gene

nadD

Organism
Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Display
All None

  • Function
  • Names & Taxonomy
  • Subcellular locationSubcell. location
  • Pathology & BiotechPathol./Biotech
  • PTM / Processing
  • Expression
  • Interaction
  • Structure
  • Family & Domains
  • Sequence
  • Cross-references
  • Publications
  • Entry information
  • Miscellaneous
  • Similar proteins
Top

Functioni

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).UniRule annotation

Catalytic activityi

ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.UniRule annotationSAAS annotation

Pathwayi

Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. nicotinate-nucleotide adenylyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciHMOD498761:GI46-2716-MONOMER.
UniPathwayiUPA00253; UER00332.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable nicotinate-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.18UniRule annotation)
Alternative name(s):
Deamido-NAD(+) diphosphorylaseUniRule annotation
Deamido-NAD(+) pyrophosphorylaseUniRule annotation
Nicotinate mononucleotide adenylyltransferaseUniRule annotation
Gene namesi
Name:nadDUniRule annotationImported
ORF Names:HM1_2701Imported
OrganismiHeliobacterium modesticaldum (strain ATCC 51547 / Ice1)Imported
Taxonomic identifieri498761 [NCBI]
Taxonomic lineageiBacteria › Firmicutes › Clostridia › Clostridiales › Heliobacteriaceae › Heliobacterium ›
ProteomesiUP000008550: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi498761.HM1_2701.

Structurei

3D structure databases

ProteinModelPortaliB0TBV7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NadD family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1057.
HOGENOMiHOG000262779.
KOiK00969.
OMAiHYGHLRP.
OrthoDBiEOG6F55KJ.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00244. NaMN_adenylyltr.
InterProiIPR004821. Cyt_trans-like.
IPR005248. NAMN_adtrnsfrase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR12039. PTHR12039. 1 hit.
PfamiPF01467. CTP_transf_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.

Sequencei

Sequence statusi: Complete.

B0TBV7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVRVGIMGGT FDPVHYGHLV TAEAAADLFD LSVVVFVPSG RPPHKQHQDV 
        60         70         80         90        100
TDPWERYRLT ELATCSNPRF RMSDVEVIRP GYSYTIDTVR AFRREYGEQA 
       110        120        130        140        150
EFFFITGADA ILEIMTWRQI DQLMAECRFI AAYRPGYGRD HLRKAVARME 
       160        170        180        190        200
AFSGRIHLVE VPALAISSTD IRRRLYEGRS VKYLLPEPVL HRIMETGVYH 
       210
LASRHRQPRE
Length:210
Mass (Da):24,237
Last modified:April 8, 2008 - v1
Checksum:i17192F8591BEE002
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000930 Genomic DNA. Translation: ABZ85230.1.
RefSeqiWP_012283715.1. NC_010337.2.
YP_001681241.1. NC_010337.2.

Genome annotation databases

EnsemblBacteriaiABZ85230; ABZ85230; HM1_2701.
GeneIDi5909809.
KEGGihmo:HM1_2701.
PATRICi22109437. VBIHelMod36755_2422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
 CP000930 Genomic DNA. Translation: ABZ85230.1 .
RefSeqi WP_012283715.1. NC_010337.2.
YP_001681241.1. NC_010337.2.

3D structure databases

ProteinModelPortali B0TBV7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 498761.HM1_2701.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ85230 ; ABZ85230 ; HM1_2701 .
GeneIDi 5909809.
KEGGi hmo:HM1_2701.
PATRICi 22109437. VBIHelMod36755_2422.

Phylogenomic databases

eggNOGi COG1057.
HOGENOMi HOG000262779.
KOi K00969.
OMAi HYGHLRP.
OrthoDBi EOG6F55KJ.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00332 .
BioCyci HMOD498761:GI46-2716-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00244. NaMN_adenylyltr.
InterProi IPR004821. Cyt_trans-like.
IPR005248. NAMN_adtrnsfrase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR12039. PTHR12039. 1 hit.
Pfami PF01467. CTP_transf_2. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
TIGR00482. TIGR00482. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Heliobacterium modesticaldum, a phototrophic representative of the Firmicutes containing the simplest photosynthetic apparatus."
    Sattley W.M., Madigan M.T., Swingley W.D., Cheung P.C., Clocksin K.M., Conrad A.L., Dejesa L.C., Honchak B.M., Jung D.O., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Page L.E., Taylor H.L., Wang Z.T., Raymond J., Chen M., Blankenship R.E., Touchman J.W.
    J. Bacteriol. 190:4687-4696(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51547 / Ice1Imported.

Entry informationi

Entry nameiB0TBV7_HELMI
AccessioniPrimary (citable) accession number: B0TBV7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: January 7, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.
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