UniProtKB - B0TBV7 (B0TBV7_HELMI)
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Protein
Probable nicotinate-nucleotide adenylyltransferase
Gene
nadD
Organism
Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Status
Functioni
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).UniRule annotation
Catalytic activityi
ATP + beta-nicotinate-D-ribonucleotide = diphosphate + deamido-NAD+.UniRule annotationSAAS annotation
: NAD(+) biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide.UniRule annotationSAAS annotationProteins known to be involved in this subpathway in this organism are:
- Probable nicotinate-nucleotide adenylyltransferase (nadD)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes deamido-NAD(+) from nicotinate D-ribonucleotide, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- nicotinate-nucleotide adenylyltransferase activity Source: UniProtKB-UniRule
GO - Biological processi
- NAD biosynthetic process Source: UniProtKB-UniRule
Keywordsi
Molecular function | NucleotidyltransferaseUniRule annotationSAAS annotationImported, Transferase |
Biological process | Pyridine nucleotide biosynthesisUniRule annotationSAAS annotation |
Ligand | ATP-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | HMOD498761:G1GB0-2481-MONOMER. |
UniPathwayi | UPA00253; UER00332. |
Names & Taxonomyi
Protein namesi | Recommended name: Probable nicotinate-nucleotide adenylyltransferaseUniRule annotation (EC:2.7.7.18UniRule annotation)Alternative name(s): Deamido-NAD(+) diphosphorylaseUniRule annotation Deamido-NAD(+) pyrophosphorylaseUniRule annotation Nicotinate mononucleotide adenylyltransferaseUniRule annotation Short name: NaMN adenylyltransferaseUniRule annotation |
Gene namesi | Name:nadDUniRule annotationImported ORF Names:HM1_2701Imported |
Organismi | Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)Imported |
Taxonomic identifieri | 498761 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Clostridia › Clostridiales › Heliobacteriaceae › Heliobacterium › |
Proteomesi |
|
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 174 | CTP_transf_likeInterPro annotationAdd BLAST | 169 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG4108Z1W. Bacteria. COG1057. LUCA. |
HOGENOMi | HOG000262779. |
KOi | K00969. |
OMAi | IHIGHLI. |
OrthoDBi | POG091H028Y. |
Family and domain databases
CDDi | cd02165. NMNAT. 1 hit. |
Gene3Di | 3.40.50.620. 1 hit. |
HAMAPi | MF_00244. NaMN_adenylyltr. 1 hit. |
InterProi | View protein in InterPro IPR004821. Cyt_trans-like. IPR005248. NadD/NMNAT. IPR014729. Rossmann-like_a/b/a_fold. |
Pfami | View protein in Pfam PF01467. CTP_transf_like. 1 hit. |
TIGRFAMsi | TIGR00125. cyt_tran_rel. 1 hit. TIGR00482. TIGR00482. 1 hit. |
i Sequence
Sequence statusi: Complete.
B0TBV7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVRVGIMGGT FDPVHYGHLV TAEAAADLFD LSVVVFVPSG RPPHKQHQDV
60 70 80 90 100
TDPWERYRLT ELATCSNPRF RMSDVEVIRP GYSYTIDTVR AFRREYGEQA
110 120 130 140 150
EFFFITGADA ILEIMTWRQI DQLMAECRFI AAYRPGYGRD HLRKAVARME
160 170 180 190 200
AFSGRIHLVE VPALAISSTD IRRRLYEGRS VKYLLPEPVL HRIMETGVYH
210
LASRHRQPRE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000930 Genomic DNA. Translation: ABZ85230.1. |
RefSeqi | WP_012283715.1. NC_010337.2. |
Genome annotation databases
EnsemblBacteriai | ABZ85230; ABZ85230; HM1_2701. |
KEGGi | hmo:HM1_2701. |
Similar proteinsi
Entry informationi
Entry namei | B0TBV7_HELMI | |
Accessioni | B0TBV7Primary (citable) accession number: B0TBV7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 8, 2008 |
Last sequence update: | April 8, 2008 | |
Last modified: | March 28, 2018 | |
This is version 75 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |