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B0TBP1

- FTHS_HELMI

UniProt

B0TBP1 - FTHS_HELMI

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHMOD498761:GI46-1297-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:Helmi_12550
    ORF Names:HM1_0672
    OrganismiHeliobacterium modesticaldum (strain ATCC 51547 / Ice1)
    Taxonomic identifieri498761 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesHeliobacteriaceaeHeliobacterium
    ProteomesiUP000008550: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000146684Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi498761.HM1_0672.

    Structurei

    3D structure databases

    ProteinModelPortaliB0TBP1.
    SMRiB0TBP1. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiIPRESGF.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0TBP1-1 [UniParc]FASTAAdd to Basket

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    MKTDIEIAQE ATLQPIMDVA RSLGIPENEV ELYGNYKAKI SLKAFERLKE    50
    RREGKLILVT AINPTPAGEG KTTTTVGLGD ALRRLGKKVV IALREPSLGP 100
    SFGVKGGAAG GGYAQIVPME DINLHFTGDF HAVTSAHNLL AAMLDNSLQQ 150
    GNPLNIDPRQ VVFRRVLDLN DRALRKVIVG LGGRTDGIPR ESGFDITVAS 200
    EIMAILCLSK DLMDLKARCA KIVVAYTYDG KPVTAADLEA QGSMAVLLKD 250
    AIKPNLVQTL EHTPAFVHGG PFANIAHGCN SVTATQLALK LGDYCVTEAG 300
    FGADLGAEKF FNLKCRLAGL KPDCTVIVAT VRALKSHGGV AKADLNRENL 350
    EALAKGFGNL EKHIENVAKF GVPAVVAINA FPTDTKAELD YVYERCRQMG 400
    IDVALSEVWA KGGEGGRELA EKVVAAIETK PSRFRVLYDS SLPIKEKIAA 450
    IVREVYGGDA VAYTPEAEKH IKTFTDLGYG ALPVCMAKTQ YSLSDDMTKI 500
    GRPEGFTVTV REVRLSAGAG FLVVITGAIM TMPGLPKRPA ACAIDIDENG 550
    RIVGLF 556
    Length:556
    Mass (Da):59,530
    Last modified:April 8, 2008 - v1
    Checksum:i6220867911A8E37A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000930 Genomic DNA. Translation: ABZ83880.1.
    RefSeqiYP_001679891.1. NC_010337.2.

    Genome annotation databases

    EnsemblBacteriaiABZ83880; ABZ83880; HM1_0672.
    GeneIDi5911277.
    KEGGihmo:HM1_0672.
    PATRICi22106769. VBIHelMod36755_1164.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000930 Genomic DNA. Translation: ABZ83880.1 .
    RefSeqi YP_001679891.1. NC_010337.2.

    3D structure databases

    ProteinModelPortali B0TBP1.
    SMRi B0TBP1. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 498761.HM1_0672.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABZ83880 ; ABZ83880 ; HM1_0672 .
    GeneIDi 5911277.
    KEGGi hmo:HM1_0672.
    PATRICi 22106769. VBIHelMod36755_1164.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi IPRESGF.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci HMOD498761:GI46-1297-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Heliobacterium modesticaldum, a phototrophic representative of the Firmicutes containing the simplest photosynthetic apparatus."
      Sattley W.M., Madigan M.T., Swingley W.D., Cheung P.C., Clocksin K.M., Conrad A.L., Dejesa L.C., Honchak B.M., Jung D.O., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Page L.E., Taylor H.L., Wang Z.T., Raymond J., Chen M., Blankenship R.E., Touchman J.W.
      J. Bacteriol. 190:4687-4696(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51547 / Ice1.

    Entry informationi

    Entry nameiFTHS_HELMI
    AccessioniPrimary (citable) accession number: B0TBP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3