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B0TBP1

- FTHS_HELMI

UniProt

B0TBP1 - FTHS_HELMI

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, Helmi_12550, HM1_0672
Organism
Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHMOD498761:GI46-1297-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Helmi_12550
ORF Names:HM1_0672
OrganismiHeliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Taxonomic identifieri498761 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesHeliobacteriaceaeHeliobacterium
ProteomesiUP000008550: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligaseUniRule annotation
PRO_1000146684Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi498761.HM1_0672.

Structurei

3D structure databases

ProteinModelPortaliB0TBP1.
SMRiB0TBP1. Positions 4-554.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIPRESGF.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0TBP1-1 [UniParc]FASTAAdd to Basket

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MKTDIEIAQE ATLQPIMDVA RSLGIPENEV ELYGNYKAKI SLKAFERLKE    50
RREGKLILVT AINPTPAGEG KTTTTVGLGD ALRRLGKKVV IALREPSLGP 100
SFGVKGGAAG GGYAQIVPME DINLHFTGDF HAVTSAHNLL AAMLDNSLQQ 150
GNPLNIDPRQ VVFRRVLDLN DRALRKVIVG LGGRTDGIPR ESGFDITVAS 200
EIMAILCLSK DLMDLKARCA KIVVAYTYDG KPVTAADLEA QGSMAVLLKD 250
AIKPNLVQTL EHTPAFVHGG PFANIAHGCN SVTATQLALK LGDYCVTEAG 300
FGADLGAEKF FNLKCRLAGL KPDCTVIVAT VRALKSHGGV AKADLNRENL 350
EALAKGFGNL EKHIENVAKF GVPAVVAINA FPTDTKAELD YVYERCRQMG 400
IDVALSEVWA KGGEGGRELA EKVVAAIETK PSRFRVLYDS SLPIKEKIAA 450
IVREVYGGDA VAYTPEAEKH IKTFTDLGYG ALPVCMAKTQ YSLSDDMTKI 500
GRPEGFTVTV REVRLSAGAG FLVVITGAIM TMPGLPKRPA ACAIDIDENG 550
RIVGLF 556
Length:556
Mass (Da):59,530
Last modified:April 8, 2008 - v1
Checksum:i6220867911A8E37A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000930 Genomic DNA. Translation: ABZ83880.1.
RefSeqiYP_001679891.1. NC_010337.2.

Genome annotation databases

EnsemblBacteriaiABZ83880; ABZ83880; HM1_0672.
GeneIDi5911277.
KEGGihmo:HM1_0672.
PATRICi22106769. VBIHelMod36755_1164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000930 Genomic DNA. Translation: ABZ83880.1 .
RefSeqi YP_001679891.1. NC_010337.2.

3D structure databases

ProteinModelPortali B0TBP1.
SMRi B0TBP1. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 498761.HM1_0672.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ83880 ; ABZ83880 ; HM1_0672 .
GeneIDi 5911277.
KEGGi hmo:HM1_0672.
PATRICi 22106769. VBIHelMod36755_1164.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IPRESGF.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci HMOD498761:GI46-1297-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Heliobacterium modesticaldum, a phototrophic representative of the Firmicutes containing the simplest photosynthetic apparatus."
    Sattley W.M., Madigan M.T., Swingley W.D., Cheung P.C., Clocksin K.M., Conrad A.L., Dejesa L.C., Honchak B.M., Jung D.O., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Page L.E., Taylor H.L., Wang Z.T., Raymond J., Chen M., Blankenship R.E., Touchman J.W.
    J. Bacteriol. 190:4687-4696(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51547 / Ice1.

Entry informationi

Entry nameiFTHS_HELMI
AccessioniPrimary (citable) accession number: B0TBP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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