Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B0TBP1

- FTHS_HELMI

UniProt

B0TBP1 - FTHS_HELMI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHMOD498761:GI46-1297-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:Helmi_12550
ORF Names:HM1_0672
OrganismiHeliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Taxonomic identifieri498761 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesHeliobacteriaceaeHeliobacterium
ProteomesiUP000008550: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000146684Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi498761.HM1_0672.

Structurei

3D structure databases

ProteinModelPortaliB0TBP1.
SMRiB0TBP1. Positions 4-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiIPRESGF.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0TBP1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKTDIEIAQE ATLQPIMDVA RSLGIPENEV ELYGNYKAKI SLKAFERLKE
60 70 80 90 100
RREGKLILVT AINPTPAGEG KTTTTVGLGD ALRRLGKKVV IALREPSLGP
110 120 130 140 150
SFGVKGGAAG GGYAQIVPME DINLHFTGDF HAVTSAHNLL AAMLDNSLQQ
160 170 180 190 200
GNPLNIDPRQ VVFRRVLDLN DRALRKVIVG LGGRTDGIPR ESGFDITVAS
210 220 230 240 250
EIMAILCLSK DLMDLKARCA KIVVAYTYDG KPVTAADLEA QGSMAVLLKD
260 270 280 290 300
AIKPNLVQTL EHTPAFVHGG PFANIAHGCN SVTATQLALK LGDYCVTEAG
310 320 330 340 350
FGADLGAEKF FNLKCRLAGL KPDCTVIVAT VRALKSHGGV AKADLNRENL
360 370 380 390 400
EALAKGFGNL EKHIENVAKF GVPAVVAINA FPTDTKAELD YVYERCRQMG
410 420 430 440 450
IDVALSEVWA KGGEGGRELA EKVVAAIETK PSRFRVLYDS SLPIKEKIAA
460 470 480 490 500
IVREVYGGDA VAYTPEAEKH IKTFTDLGYG ALPVCMAKTQ YSLSDDMTKI
510 520 530 540 550
GRPEGFTVTV REVRLSAGAG FLVVITGAIM TMPGLPKRPA ACAIDIDENG

RIVGLF
Length:556
Mass (Da):59,530
Last modified:April 8, 2008 - v1
Checksum:i6220867911A8E37A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000930 Genomic DNA. Translation: ABZ83880.1.
RefSeqiYP_001679891.1. NC_010337.2.

Genome annotation databases

EnsemblBacteriaiABZ83880; ABZ83880; HM1_0672.
GeneIDi5911277.
KEGGihmo:HM1_0672.
PATRICi22106769. VBIHelMod36755_1164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000930 Genomic DNA. Translation: ABZ83880.1 .
RefSeqi YP_001679891.1. NC_010337.2.

3D structure databases

ProteinModelPortali B0TBP1.
SMRi B0TBP1. Positions 4-554.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 498761.HM1_0672.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ83880 ; ABZ83880 ; HM1_0672 .
GeneIDi 5911277.
KEGGi hmo:HM1_0672.
PATRICi 22106769. VBIHelMod36755_1164.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi IPRESGF.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci HMOD498761:GI46-1297-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Heliobacterium modesticaldum, a phototrophic representative of the Firmicutes containing the simplest photosynthetic apparatus."
    Sattley W.M., Madigan M.T., Swingley W.D., Cheung P.C., Clocksin K.M., Conrad A.L., Dejesa L.C., Honchak B.M., Jung D.O., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Page L.E., Taylor H.L., Wang Z.T., Raymond J., Chen M., Blankenship R.E., Touchman J.W.
    J. Bacteriol. 190:4687-4696(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51547 / Ice1.

Entry informationi

Entry nameiFTHS_HELMI
AccessioniPrimary (citable) accession number: B0TBP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: October 1, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3