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B0TBJ3

- SYL_HELMI

UniProt

B0TBJ3 - SYL_HELMI

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Protein

Leucine--tRNA ligase

Gene
leuS, Helmi_25810, HM1_2677
Organism
Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei589 – 5891ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHMOD498761:GI46-2692-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Helmi_25810
ORF Names:HM1_2677
OrganismiHeliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Taxonomic identifieri498761 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesHeliobacteriaceaeHeliobacterium
ProteomesiUP000008550: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 846846Leucine--tRNA ligaseUniRule annotationPRO_1000091322Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi498761.HM1_2677.

Structurei

3D structure databases

ProteinModelPortaliB0TBJ3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi586 – 5905"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiKGNPLES.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 2 hits.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0TBJ3-1 [UniParc]FASTAAdd to Basket

« Hide

MQERYDYQQI EKKWQKYWAD TGMFRLQQEE GRPKYYCLEM FPYPSGNLHM    50
GHVRVYSIGD VVARFKTMQG YNVLHPMGWD AFGLPAENAA IKHKVPPADW 100
TWSNIANMRR QLQSMGISYD WEREVATCHP DYYKWTQWLF LQLYKAGLAY 150
KKKANVNWCP DCATVLANEQ VVDGLCERCD ATVEKKALEQ WFFRITDYAQ 200
RLLDDLNKLP GWPDKVKTMQ ENWIGRSEGV EADFALENPV GGVDKLTVYT 250
TRQDTIFGVT YMVLAPEHPA VEALVSGNPR EAELRAFIKK VLSQSEIDRT 300
ANDTEKEGIF TGHYCINPLT GEKVAVYLAN YVLVDYGTGA VMGVPAHDQR 350
DFEFATKYNI PMKVVIQPEG LPDLDVEEMD HAYEGEGRLV NSGEFDGLIN 400
TQALDVIADK LEREGKGVRK VNYRLRDWLI SRQRYWGAPI PVIYCEKCGE 450
VAVPDEQLPV MLPTDVAFTP SGESPLTSRP DFYECTCPRC GGKGRRETDT 500
MDTFVCSSWY FLRYCTPKDK DHAFLQEDVD YWMNVDQYIG GVEHAILHLM 550
YARFFTKVLY DLKLVKVEEP FENLLTQGMV LMGGSKMSKS KGNTVSPEEI 600
IAKYGADTAR LFILFAAPPE RDLEWSDRGV EGAHRFLHRL WRLVYAYSDQ 650
IASVPGTMVG YGKGQPNGSK GDNLFSLNSD DRELVRVAHY TVKKVTEDIG 700
QRFNFNTAVS AIMEMVNYFY QYKDKVPAEQ QNIPLVKDAL ARLVLVLAPF 750
APHICEELWQ VIGGGESVYK QPWPTYDEQA LVRDEVEVVV QINGKVREKL 800
RVANGLDGEA IKAKVLEMDK VQALIAGKSV VKLITVPNKL VNIVVK 846
Length:846
Mass (Da):96,367
Last modified:April 8, 2008 - v1
Checksum:iD4062D5A09098691
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000930 Genomic DNA. Translation: ABZ85206.1.
RefSeqiWP_012283691.1. NC_010337.2.
YP_001681217.1. NC_010337.2.

Genome annotation databases

EnsemblBacteriaiABZ85206; ABZ85206; HM1_2677.
GeneIDi5909903.
KEGGihmo:HM1_2677.
PATRICi22109393. VBIHelMod36755_2400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000930 Genomic DNA. Translation: ABZ85206.1 .
RefSeqi WP_012283691.1. NC_010337.2.
YP_001681217.1. NC_010337.2.

3D structure databases

ProteinModelPortali B0TBJ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 498761.HM1_2677.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ85206 ; ABZ85206 ; HM1_2677 .
GeneIDi 5909903.
KEGGi hmo:HM1_2677.
PATRICi 22109393. VBIHelMod36755_2400.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi KGNPLES.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci HMOD498761:GI46-2692-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 2 hits.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Heliobacterium modesticaldum, a phototrophic representative of the Firmicutes containing the simplest photosynthetic apparatus."
    Sattley W.M., Madigan M.T., Swingley W.D., Cheung P.C., Clocksin K.M., Conrad A.L., Dejesa L.C., Honchak B.M., Jung D.O., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Page L.E., Taylor H.L., Wang Z.T., Raymond J., Chen M., Blankenship R.E., Touchman J.W.
    J. Bacteriol. 190:4687-4696(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51547 / Ice1.

Entry informationi

Entry nameiSYL_HELMI
AccessioniPrimary (citable) accession number: B0TBJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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