Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei589ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciHMOD498761:G1GB0-2460-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Helmi_25810
ORF Names:HM1_2677
OrganismiHeliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Taxonomic identifieri498761 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesHeliobacteriaceaeHeliobacterium
Proteomesi
  • UP000008550 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000913221 – 846Leucine--tRNA ligaseAdd BLAST846

Proteomic databases

PRIDEiB0TBJ3

Interactioni

Protein-protein interaction databases

STRINGi498761.HM1_2677

Structurei

3D structure databases

ProteinModelPortaliB0TBJ3
SMRiB0TBJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 52"HIGH" regionAdd BLAST11
Motifi586 – 590"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 2 hits
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B0TBJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQERYDYQQI EKKWQKYWAD TGMFRLQQEE GRPKYYCLEM FPYPSGNLHM
60 70 80 90 100
GHVRVYSIGD VVARFKTMQG YNVLHPMGWD AFGLPAENAA IKHKVPPADW
110 120 130 140 150
TWSNIANMRR QLQSMGISYD WEREVATCHP DYYKWTQWLF LQLYKAGLAY
160 170 180 190 200
KKKANVNWCP DCATVLANEQ VVDGLCERCD ATVEKKALEQ WFFRITDYAQ
210 220 230 240 250
RLLDDLNKLP GWPDKVKTMQ ENWIGRSEGV EADFALENPV GGVDKLTVYT
260 270 280 290 300
TRQDTIFGVT YMVLAPEHPA VEALVSGNPR EAELRAFIKK VLSQSEIDRT
310 320 330 340 350
ANDTEKEGIF TGHYCINPLT GEKVAVYLAN YVLVDYGTGA VMGVPAHDQR
360 370 380 390 400
DFEFATKYNI PMKVVIQPEG LPDLDVEEMD HAYEGEGRLV NSGEFDGLIN
410 420 430 440 450
TQALDVIADK LEREGKGVRK VNYRLRDWLI SRQRYWGAPI PVIYCEKCGE
460 470 480 490 500
VAVPDEQLPV MLPTDVAFTP SGESPLTSRP DFYECTCPRC GGKGRRETDT
510 520 530 540 550
MDTFVCSSWY FLRYCTPKDK DHAFLQEDVD YWMNVDQYIG GVEHAILHLM
560 570 580 590 600
YARFFTKVLY DLKLVKVEEP FENLLTQGMV LMGGSKMSKS KGNTVSPEEI
610 620 630 640 650
IAKYGADTAR LFILFAAPPE RDLEWSDRGV EGAHRFLHRL WRLVYAYSDQ
660 670 680 690 700
IASVPGTMVG YGKGQPNGSK GDNLFSLNSD DRELVRVAHY TVKKVTEDIG
710 720 730 740 750
QRFNFNTAVS AIMEMVNYFY QYKDKVPAEQ QNIPLVKDAL ARLVLVLAPF
760 770 780 790 800
APHICEELWQ VIGGGESVYK QPWPTYDEQA LVRDEVEVVV QINGKVREKL
810 820 830 840
RVANGLDGEA IKAKVLEMDK VQALIAGKSV VKLITVPNKL VNIVVK
Length:846
Mass (Da):96,367
Last modified:April 8, 2008 - v1
Checksum:iD4062D5A09098691
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000930 Genomic DNA Translation: ABZ85206.1
RefSeqiWP_012283691.1, NC_010337.2

Genome annotation databases

EnsemblBacteriaiABZ85206; ABZ85206; HM1_2677
KEGGihmo:HM1_2677

Similar proteinsi

Entry informationi

Entry nameiSYL_HELMI
AccessioniPrimary (citable) accession number: B0TBJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health