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B0TBJ3

- SYL_HELMI

UniProt

B0TBJ3 - SYL_HELMI

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Heliobacterium modesticaldum (strain ATCC 51547 / Ice1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei589 – 5891ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciHMOD498761:GI46-2692-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Helmi_25810
    ORF Names:HM1_2677
    OrganismiHeliobacterium modesticaldum (strain ATCC 51547 / Ice1)
    Taxonomic identifieri498761 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesHeliobacteriaceaeHeliobacterium
    ProteomesiUP000008550: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 846846Leucine--tRNA ligasePRO_1000091322Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi498761.HM1_2677.

    Structurei

    3D structure databases

    ProteinModelPortaliB0TBJ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi586 – 5905"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiKGNPLES.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 2 hits.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0TBJ3-1 [UniParc]FASTAAdd to Basket

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    MQERYDYQQI EKKWQKYWAD TGMFRLQQEE GRPKYYCLEM FPYPSGNLHM    50
    GHVRVYSIGD VVARFKTMQG YNVLHPMGWD AFGLPAENAA IKHKVPPADW 100
    TWSNIANMRR QLQSMGISYD WEREVATCHP DYYKWTQWLF LQLYKAGLAY 150
    KKKANVNWCP DCATVLANEQ VVDGLCERCD ATVEKKALEQ WFFRITDYAQ 200
    RLLDDLNKLP GWPDKVKTMQ ENWIGRSEGV EADFALENPV GGVDKLTVYT 250
    TRQDTIFGVT YMVLAPEHPA VEALVSGNPR EAELRAFIKK VLSQSEIDRT 300
    ANDTEKEGIF TGHYCINPLT GEKVAVYLAN YVLVDYGTGA VMGVPAHDQR 350
    DFEFATKYNI PMKVVIQPEG LPDLDVEEMD HAYEGEGRLV NSGEFDGLIN 400
    TQALDVIADK LEREGKGVRK VNYRLRDWLI SRQRYWGAPI PVIYCEKCGE 450
    VAVPDEQLPV MLPTDVAFTP SGESPLTSRP DFYECTCPRC GGKGRRETDT 500
    MDTFVCSSWY FLRYCTPKDK DHAFLQEDVD YWMNVDQYIG GVEHAILHLM 550
    YARFFTKVLY DLKLVKVEEP FENLLTQGMV LMGGSKMSKS KGNTVSPEEI 600
    IAKYGADTAR LFILFAAPPE RDLEWSDRGV EGAHRFLHRL WRLVYAYSDQ 650
    IASVPGTMVG YGKGQPNGSK GDNLFSLNSD DRELVRVAHY TVKKVTEDIG 700
    QRFNFNTAVS AIMEMVNYFY QYKDKVPAEQ QNIPLVKDAL ARLVLVLAPF 750
    APHICEELWQ VIGGGESVYK QPWPTYDEQA LVRDEVEVVV QINGKVREKL 800
    RVANGLDGEA IKAKVLEMDK VQALIAGKSV VKLITVPNKL VNIVVK 846
    Length:846
    Mass (Da):96,367
    Last modified:April 8, 2008 - v1
    Checksum:iD4062D5A09098691
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000930 Genomic DNA. Translation: ABZ85206.1.
    RefSeqiWP_012283691.1. NC_010337.2.
    YP_001681217.1. NC_010337.2.

    Genome annotation databases

    EnsemblBacteriaiABZ85206; ABZ85206; HM1_2677.
    GeneIDi5909903.
    KEGGihmo:HM1_2677.
    PATRICi22109393. VBIHelMod36755_2400.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000930 Genomic DNA. Translation: ABZ85206.1 .
    RefSeqi WP_012283691.1. NC_010337.2.
    YP_001681217.1. NC_010337.2.

    3D structure databases

    ProteinModelPortali B0TBJ3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 498761.HM1_2677.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABZ85206 ; ABZ85206 ; HM1_2677 .
    GeneIDi 5909903.
    KEGGi hmo:HM1_2677.
    PATRICi 22109393. VBIHelMod36755_2400.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi KGNPLES.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci HMOD498761:GI46-2692-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 2 hits.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Heliobacterium modesticaldum, a phototrophic representative of the Firmicutes containing the simplest photosynthetic apparatus."
      Sattley W.M., Madigan M.T., Swingley W.D., Cheung P.C., Clocksin K.M., Conrad A.L., Dejesa L.C., Honchak B.M., Jung D.O., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Page L.E., Taylor H.L., Wang Z.T., Raymond J., Chen M., Blankenship R.E., Touchman J.W.
      J. Bacteriol. 190:4687-4696(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51547 / Ice1.

    Entry informationi

    Entry nameiSYL_HELMI
    AccessioniPrimary (citable) accession number: B0TBJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3