B0TAY4 (SURE_HELMI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	Helmi_24700
ORF Names:	HM1_2558

Organism

Heliobacterium modesticaldum (strain ATCC 51547 / Ice1) [Complete proteome] [HAMAP]

Taxonomic identifier

498761 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Heliobacteriaceae › Heliobacterium

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	5'-nucleotidase surE HAMAP MF_00060		PRO_1000092007
Sites
	Metal binding	8	1	Divalent metal cation By similarity
	Metal binding	9	1	Divalent metal cation By similarity
	Metal binding	39	1	Divalent metal cation By similarity
	Metal binding	96	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0TAY4 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 1D14BD18E0733325	FASTA	272	29,653
	10 20 30 40 50 60 MRILLTNDDG IHAPGIHALW RIFDDWADIF VVAPDTERSA TGHGITVHQP LRVEKLSFAN 70 80 90 100 110 120 PHCHGWAVNG TPADCVKLAM EELLAEPPHI VISGINRGPN LGTDVLYSGT VSAAMEGVIY 130 140 150 160 170 180 GVPSIAVSVT GWHTADYTVA AETTRLLCEK LVARGLTPDT FLNVNVPDLP RERIAGIQVT 190 200 210 220 230 240 KLGSRRYQNI FDKRTDPRGR TYYWMAGEVH DVDAGEGTDI SAVNAGAISV TPIHFDLTNY 250 260 270 SLIQEVSDWL GGGSSPFADR NKKDDVETKR KA

References

[1]

"The genome of Heliobacterium modesticaldum, a phototrophic representative of the Firmicutes containing the simplest photosynthetic apparatus." Sattley W.M., Madigan M.T., Swingley W.D., Cheung P.C., Clocksin K.M., Conrad A.L., Dejesa L.C., Honchak B.M., Jung D.O., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Page L.E., Taylor H.L., Wang Z.T., Raymond J., Chen M., Blankenship R.E., Touchman J.W. J. Bacteriol. 190:4687-4696(2008) [PubMed: 18441057] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51547 / Ice1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000930 Genomic DNA. Translation: ABZ85095.1.
RefSeq	YP_001681106.1. NC_010337.2.
3D structure databases
ProteinModelPortal	B0TAY4.
ModBase	Search...
Protein-protein interaction databases
STRING	B0TAY4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5909220.
GenomeReviews	Gene locus Helmi_24700 in contig CP000930_GR.
KEGG	hmo:HM1_2558.
PATRIC	22109171. VBIHelMod36755_2296.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG600532.
OMA	NGFYYVN.
ProtClustDB	PRK00346.
Enzyme and pathway databases
BioCyc	HMOD498761:HM1_2558-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_HELMI

Accession

Primary (citable) accession number: B0TAY4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 8, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program