ID   ASTD_CAUSK              Reviewed;         484 AA.
AC   B0T8I8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   16-JUN-2009, entry version 10.
DE   RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase;
DE            EC=1.2.1.71;
DE   AltName: Full=Succinylglutamic semialdehyde dehydrogenase;
DE            Short=SGSD;
GN   Name=astD; OrderedLocusNames=Caul_2203;
OS   Caulobacter sp. (strain K31).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Caulobacterales;
OC   Caulobacteraceae; Caulobacter.
OX   NCBI_TaxID=366602;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T.,
RA   Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S.,
RA   Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M.,
RA   Hauser L., Kyrpides N., Kim E., Stephens C., Richardson P.;
RT   "Complete sequence of chromosome of Caulobacter sp. K31.";
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the NAD-dependent reduction of
CC       succinylglutamate semialdehyde into succinylglutamate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD(+)
CC       + H(2)O = N-succinyl-L-glutamate + NADH.
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via AST
CC       pathway; L-glutamate and succinate from L-arginine: step 4/5.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD
CC       subfamily.
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DR   EMBL; CP000927; ABZ71331.1; -; Genomic_DNA.
DR   RefSeq; YP_001683829.1; -.
DR   GeneID; 5899658; -.
DR   GenomeReviews; CP000927_GR; Caul_2203.
DR   KEGG; cak:Caul_2203; -.
DR   OMA; B0T8I8; FAPLLQV.
DR   GO; GO:0043824; F:succinylglutamate-semialdehyde dehydrogenas...; IEA:EC.
DR   GO; GO:0019544; P:arginine catabolic process to glutamate; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01174; -; 1.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   InterPro; IPR017649; SuccinylGlu_semiald_DH_AstD.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR03240; arg_catab_astD; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    484       N-succinylglutamate 5-semialdehyde
FT                                dehydrogenase.
FT                                /FTId=PRO_1000085401.
FT   NP_BIND     221    226       NAD (By similarity).
FT   ACT_SITE    244    244       By similarity.
FT   ACT_SITE    278    278       By similarity.
SQ   SEQUENCE   484 AA;  50856 MW;  245C47C7B0CDFEE0 CRC64;
     MSGGLFIDGV WRAGAGAQAT SVDPTTGEVI WRQATASTAE VAAAVEAARK AFPAWADRSR
     EERIAVLRRY KDVLVARTGT FAEALSRETG KALWETKAEL GSMAGKVEAS IKAYDERTGE
     HANDMAFGRA VLRHRAHGVM AVLGPFNFPG HLPNGHIVPA LLAGDTVVFK PSEETPLAGQ
     LLVEALEEAG VPAGVINLVQ GGREVGQALI DQEIDGLLFT GSAAAGAFFR RHFADRPDVI
     LALELGGNNP LVVWDAGDPE AVAALIVQSA FITTGQRCSC ARRLIVSDDA AGRAVIDAVA
     ALSERLVIGP WNGGQEPFMG PLISDRAAAM ALAGAKAMPG QTLRAMTSVD GLSRAFVSPG
     LVDVTGETVP DEELFAPLLQ VRRVGSFEEA IAAANATRYG LSAGLVSNET AHWDRFLTRI
     RAGVVNWNRP TTGAAGTMPF GGLGNSGNHR PSAYYAADYC AYPVASFEAE NVTNTLGDIK
     GLRA
//