Reviewed, UniProtKB/Swiss-Prot B0T8I8 (ASTD_CAUSK)

Names and origin

Protein names

Recommended name:
    N-succinylglutamate 5-semialdehyde dehydrogenase
    EC=1.2.1.71
Alternative name(s):
    Succinylglutamic semialdehyde dehydrogenase
      Short name=SGSD

Gene names

Name:	astD
Ordered Locus Names:	Caul_2203

Organism

Caulobacter sp. (strain K31) [Complete proteome] [HAMAP]

Taxonomic identifier

366602 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	484 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity.
Catalytic activity	N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174
Pathway	Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174
Sequence similarities	Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
Biological process	Arginine metabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process to glutamate Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	succinylglutamate-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 484	484	N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174		PRO_1000085401
Regions
	Nucleotide binding	221 – 226	6	NAD By similarity
Sites
	Active site	244	1	By similarity
	Active site	278	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0T8I8-1 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 245C47C7B0CDFEE0	FASTA	484	50,856
	10 20 30 40 50 60 MSGGLFIDGV WRAGAGAQAT SVDPTTGEVI WRQATASTAE VAAAVEAARK AFPAWADRSR 70 80 90 100 110 120 EERIAVLRRY KDVLVARTGT FAEALSRETG KALWETKAEL GSMAGKVEAS IKAYDERTGE 130 140 150 160 170 180 HANDMAFGRA VLRHRAHGVM AVLGPFNFPG HLPNGHIVPA LLAGDTVVFK PSEETPLAGQ 190 200 210 220 230 240 LLVEALEEAG VPAGVINLVQ GGREVGQALI DQEIDGLLFT GSAAAGAFFR RHFADRPDVI 250 260 270 280 290 300 LALELGGNNP LVVWDAGDPE AVAALIVQSA FITTGQRCSC ARRLIVSDDA AGRAVIDAVA 310 320 330 340 350 360 ALSERLVIGP WNGGQEPFMG PLISDRAAAM ALAGAKAMPG QTLRAMTSVD GLSRAFVSPG 370 380 390 400 410 420 LVDVTGETVP DEELFAPLLQ VRRVGSFEEA IAAANATRYG LSAGLVSNET AHWDRFLTRI 430 440 450 460 470 480 RAGVVNWNRP TTGAAGTMPF GGLGNSGNHR PSAYYAADYC AYPVASFEAE NVTNTLGDIK GLRA

References

[1]

"Complete sequence of chromosome of Caulobacter sp. K31." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Kim E., Stephens C., Richardson P. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000927 Genomic DNA. Translation: ABZ71331.1.
RefSeq	YP_001683829.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5899658.
GenomeReviews	Gene locus Caul_2203 in contig CP000927_GR.
KEGG	cak:Caul_2203.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	B0T8I8. FAPLLQV.
Family and domain databases
HAMAP	MF_01174. [Tree]
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR017649. SuccinylGlu_semiald_DH_AstD. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03240. arg_catab_astD. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ASTD_CAUSK

Accession

Primary (citable) accession number: B0T8I8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 8, 2008
Last modified:	June 16, 2009
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)