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B0T8I8 (ASTD_CAUSK) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase
EC=1.2.1.71
Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase
Short name=SGSD
Gene names
Name:astD
Ordered Locus Names:Caul_2203
OrganismCaulobacter sp. (strain K31) [Complete proteome] [HAMAP]
Taxonomic identifier366602 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length484 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
   Biological processArginine metabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionsuccinylglutamate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 484484N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174
PRO_1000085401

Regions

Nucleotide binding221 – 2266NAD By similarity

Sites

Active site2441 By similarity
Active site2781 By similarity

Sequences

Sequence LengthMass (Da)Tools
B0T8I8 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 245C47C7B0CDFEE0

FASTA48450,856
        10         20         30         40         50         60 
MSGGLFIDGV WRAGAGAQAT SVDPTTGEVI WRQATASTAE VAAAVEAARK AFPAWADRSR 

        70         80         90        100        110        120 
EERIAVLRRY KDVLVARTGT FAEALSRETG KALWETKAEL GSMAGKVEAS IKAYDERTGE 

       130        140        150        160        170        180 
HANDMAFGRA VLRHRAHGVM AVLGPFNFPG HLPNGHIVPA LLAGDTVVFK PSEETPLAGQ 

       190        200        210        220        230        240 
LLVEALEEAG VPAGVINLVQ GGREVGQALI DQEIDGLLFT GSAAAGAFFR RHFADRPDVI 

       250        260        270        280        290        300 
LALELGGNNP LVVWDAGDPE AVAALIVQSA FITTGQRCSC ARRLIVSDDA AGRAVIDAVA 

       310        320        330        340        350        360 
ALSERLVIGP WNGGQEPFMG PLISDRAAAM ALAGAKAMPG QTLRAMTSVD GLSRAFVSPG 

       370        380        390        400        410        420 
LVDVTGETVP DEELFAPLLQ VRRVGSFEEA IAAANATRYG LSAGLVSNET AHWDRFLTRI 

       430        440        450        460        470        480 
RAGVVNWNRP TTGAAGTMPF GGLGNSGNHR PSAYYAADYC AYPVASFEAE NVTNTLGDIK 


GLRA

« Hide

References

[1]"Complete sequence of chromosome of Caulobacter sp. K31."
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Kim E., Stephens C., Richardson P.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K31.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000927 Genomic DNA. Translation: ABZ71331.1.
RefSeqYP_001683829.1. NC_010338.1.

3D structure databases

ProteinModelPortalB0T8I8.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0T8I8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5899658.
GenomeReviewsGene locus Caul_2203 in contig CP000927_GR.
KEGGcak:Caul_2203.
PATRIC21317470. VBICauSp18104_2592.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG752218.
OMAHANDMAF.
ProtClustDBCLSK890509.

Enzyme and pathway databases

BioCycCSP78:CAUL_2203-MONOMER.

Family and domain databases

HAMAPMF_01174. Aldedh_AstD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK06447.
PANTHERPTHR11699:SF24. PTHR11699:SF24. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR03240. Arg_catab_astD. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASTD_CAUSK
AccessionPrimary (citable) accession number: B0T8I8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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