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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Caulobacter sp. (strain K31)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi263Magnesium or manganese 1UniRule annotation1
Metal bindingi277Magnesium or manganese 1UniRule annotation1
Metal bindingi277Magnesium or manganese 2UniRule annotation1
Metal bindingi279Magnesium or manganese 2UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi137 – 191ATPUniRule annotationAdd BLAST55

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:Caul_3660
OrganismiCaulobacter sp. (strain K31)
Taxonomic identifieri366602 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001316 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003410811 – 322D-alanine--D-alanine ligaseAdd BLAST322

Interactioni

Protein-protein interaction databases

STRINGi366602.Caul_3660.

Structurei

3D structure databases

ProteinModelPortaliB0T824.
SMRiB0T824.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 310ATP-graspUniRule annotationAdd BLAST201

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CPF. Bacteria.
COG1181. LUCA.
HOGENOMiHOG000011592.
KOiK01921.
OMAiYETKYTE.
OrthoDBiPOG091H00GT.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PIRSFiPIRSF039102. Ddl/VanB. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B0T824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPANPKPLA NHHIAVLLGG PSAEREVSLV TGAAYAAALE RLGARVSRVD
60 70 80 90 100
PGKDVAQVLT ALAPDLVFNG LHGRWGEDGC VQGVLETLGL AYTHSGVLAS
110 120 130 140 150
ALAMDKAKSK AVLAAAGIPV PGGGLFDRHD VAQGHVMPPP YVVKPNAEGS
160 170 180 190 200
SVGVSLVFEG ANGPPRQLAA PDWAFGEQVM VEPYIPGLEL AVAVVGESNG
210 220 230 240 250
PRALAVTEIR SSTGFYDYDA KYSQGGSIHV LPAPIPDAVR DRALHLAKLG
260 270 280 290 300
HTALGCQGVT RSDFRYDDIN DLLVLLEVNT QPGMTPTSLV PEQADHAGVS
310 320
FDRLVFWIVE DAYARRFAGG IA
Length:322
Mass (Da):33,688
Last modified:April 8, 2008 - v1
Checksum:iD229DF9B3A82E1E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000927 Genomic DNA. Translation: ABZ72787.1.
RefSeqiWP_012287679.1. NC_010338.1.

Genome annotation databases

EnsemblBacteriaiABZ72787; ABZ72787; Caul_3660.
KEGGicak:Caul_3660.

Similar proteinsi

Entry informationi

Entry nameiDDL_CAUSK
AccessioniPrimary (citable) accession number: B0T824
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 8, 2008
Last modified: August 30, 2017
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families