Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B0T824 (DDL_CAUSK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:Caul_3660
OrganismCaulobacter sp. (strain K31) [Complete proteome] [HAMAP]
Taxonomic identifier366602 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341081

Regions

Domain110 – 310201ATP-grasp
Nucleotide binding137 – 19155ATP By similarity

Sites

Metal binding2631Magnesium or manganese 1 By similarity
Metal binding2771Magnesium or manganese 1 By similarity
Metal binding2771Magnesium or manganese 2 By similarity
Metal binding2791Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
B0T824 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: D229DF9B3A82E1E3

FASTA32233,688
        10         20         30         40         50         60 
MTPANPKPLA NHHIAVLLGG PSAEREVSLV TGAAYAAALE RLGARVSRVD PGKDVAQVLT 

        70         80         90        100        110        120 
ALAPDLVFNG LHGRWGEDGC VQGVLETLGL AYTHSGVLAS ALAMDKAKSK AVLAAAGIPV 

       130        140        150        160        170        180 
PGGGLFDRHD VAQGHVMPPP YVVKPNAEGS SVGVSLVFEG ANGPPRQLAA PDWAFGEQVM 

       190        200        210        220        230        240 
VEPYIPGLEL AVAVVGESNG PRALAVTEIR SSTGFYDYDA KYSQGGSIHV LPAPIPDAVR 

       250        260        270        280        290        300 
DRALHLAKLG HTALGCQGVT RSDFRYDDIN DLLVLLEVNT QPGMTPTSLV PEQADHAGVS 

       310        320 
FDRLVFWIVE DAYARRFAGG IA 

« Hide

References

[1]"Complete sequence of chromosome of Caulobacter sp. K31."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Kim E., Stephens C., Richardson P.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K31.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000927 Genomic DNA. Translation: ABZ72787.1.
RefSeqYP_001685285.1. NC_010338.1.

3D structure databases

ProteinModelPortalB0T824.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING366602.Caul_3660.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABZ72787; ABZ72787; Caul_3660.
GeneID5901115.
KEGGcak:Caul_3660.
PATRIC21320452. VBICauSp18104_4064.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMAWREAARY.
OrthoDBEOG6ND0KB.
ProtClustDBPRK01372.

Enzyme and pathway databases

BioCycCSP366602:GH0Y-3696-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_CAUSK
AccessionPrimary (citable) accession number: B0T824
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 8, 2008
Last modified: February 19, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways