Reviewed, UniProtKB/Swiss-Prot B0T816 (HGD_CAUSK)

Names and origin

Protein names

Recommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase

Gene names

Name:	hmgA
Ordered Locus Names:	Caul_3652

Organism

Caulobacter sp. (strain K31) [Complete proteome] [HAMAP]

Taxonomic identifier

366602 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	427 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Homogentisate + O2 = 4-maleylacetoacetate. HAMAP MF_00334
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 4/6. HAMAP MF_00334
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 427	427	Homogentisate 1,2-dioxygenase HAMAP MF_00334		PRO_1000079265
Sites
	Metal binding	328	1	Iron By similarity
	Metal binding	334	1	Iron By similarity
	Metal binding	364	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0T816-1 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 983B92E37D43B915	FASTA	427	46,825
	10 20 30 40 50 60 MDLQYQSGFA NHFSTEAVPG ALPVGQNSPQ APPYGLYAEQ LSGTAFTAPR HENRRSWLYR 70 80 90 100 110 120 LRPSAGHGPY APYVQERLKS GPFGAAVPTP NRLRWDPLEI PEAPLDFVDG LVTLAGNGDV 130 140 150 160 170 180 ATQAGMAAHL YLANRSMIDR VFQNADGELL IVPQLGALRF VTELGVIDAA PGEVVVIPRG 190 200 210 220 230 240 VRFRVELEGP VRGYVCENYG PMFRLPELGP IGSNGLANSR DFLTPVAAFE DVERPTEVIQ 250 260 270 280 290 300 KFQGGLWTGT WDHSPLDVVA WHGNLAPYKY DLARFNTMGT VSFDHPDPSI FTVLTAPSEI 310 320 330 340 350 360 PGTANVDFVI FPPRWMVAEH TFRPPWFHRN VMSEFMGLVT GAYDAKAGGF SPGGASLHNM 370 380 390 400 410 420 MSDHGPDVAS HKAASEADLS PHKIEATMAF MFESRWVIRP TKYALETSEL QADYDACWTG FPKAKLP

References

[1]

"Complete sequence of chromosome of Caulobacter sp. K31." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Kim E., Stephens C., Richardson P. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000927 Genomic DNA. Translation: ABZ72779.1.
RefSeq	YP_001685277.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5901107.
GenomeReviews	Gene locus Caul_3652 in contig CP000927_GR.
KEGG	cak:Caul_3652.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	B0T816. HRNCMSE.
Family and domain databases
HAMAP	MF_00334. [Tree]
InterPro	IPR005708. Homogentis_dOase. [Graphical view]
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_CAUSK

Accession

Primary (citable) accession number: B0T816

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 8, 2008
Last modified:	June 16, 2009
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)