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B0T816

- HGD_CAUSK

UniProt

B0T816 - HGD_CAUSK

Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Caulobacter sp. (strain K31)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

    Catalytic activityi

    Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

    Cofactori

    Iron.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei285 – 2851Proton acceptorUniRule annotation
    Metal bindingi328 – 3281IronUniRule annotation
    Metal bindingi334 – 3341IronUniRule annotation
    Binding sitei343 – 3431homogentisateUniRule annotation
    Metal bindingi364 – 3641IronUniRule annotation
    Binding sitei364 – 3641homogentisateUniRule annotation

    GO - Molecular functioni

    1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
    2. iron ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
    2. tyrosine catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciCSP366602:GH0Y-3688-MONOMER.
    UniPathwayiUPA00139; UER00339.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
    Short name:
    HGDOUniRule annotation
    Alternative name(s):
    Homogentisate oxygenaseUniRule annotation
    Homogentisic acid oxidaseUniRule annotation
    HomogentisicaseUniRule annotation
    Gene namesi
    Name:hmgAUniRule annotation
    Ordered Locus Names:Caul_3652
    OrganismiCaulobacter sp. (strain K31)
    Taxonomic identifieri366602 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
    ProteomesiUP000001316: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 427427Homogentisate 1,2-dioxygenasePRO_1000079265Add
    BLAST

    Interactioni

    Subunit structurei

    Hexamer; dimer of trimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi366602.Caul_3652.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the homogentisate dioxygenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3508.
    HOGENOMiHOG000139824.
    KOiK00451.
    OMAiFQSPVAC.
    OrthoDBiEOG6D5FZK.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    HAMAPiMF_00334. Homogentis_dioxygen.
    InterProiIPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR11056. PTHR11056. 1 hit.
    PfamiPF04209. HgmA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR01015. hmgA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0T816-1 [UniParc]FASTAAdd to Basket

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    MDLQYQSGFA NHFSTEAVPG ALPVGQNSPQ APPYGLYAEQ LSGTAFTAPR    50
    HENRRSWLYR LRPSAGHGPY APYVQERLKS GPFGAAVPTP NRLRWDPLEI 100
    PEAPLDFVDG LVTLAGNGDV ATQAGMAAHL YLANRSMIDR VFQNADGELL 150
    IVPQLGALRF VTELGVIDAA PGEVVVIPRG VRFRVELEGP VRGYVCENYG 200
    PMFRLPELGP IGSNGLANSR DFLTPVAAFE DVERPTEVIQ KFQGGLWTGT 250
    WDHSPLDVVA WHGNLAPYKY DLARFNTMGT VSFDHPDPSI FTVLTAPSEI 300
    PGTANVDFVI FPPRWMVAEH TFRPPWFHRN VMSEFMGLVT GAYDAKAGGF 350
    SPGGASLHNM MSDHGPDVAS HKAASEADLS PHKIEATMAF MFESRWVIRP 400
    TKYALETSEL QADYDACWTG FPKAKLP 427
    Length:427
    Mass (Da):46,825
    Last modified:April 8, 2008 - v1
    Checksum:i983B92E37D43B915
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000927 Genomic DNA. Translation: ABZ72779.1.
    RefSeqiWP_012287671.1. NC_010338.1.
    YP_001685277.1. NC_010338.1.

    Genome annotation databases

    EnsemblBacteriaiABZ72779; ABZ72779; Caul_3652.
    GeneIDi5901107.
    KEGGicak:Caul_3652.
    PATRICi21320436. VBICauSp18104_4056.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000927 Genomic DNA. Translation: ABZ72779.1 .
    RefSeqi WP_012287671.1. NC_010338.1.
    YP_001685277.1. NC_010338.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 366602.Caul_3652.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABZ72779 ; ABZ72779 ; Caul_3652 .
    GeneIDi 5901107.
    KEGGi cak:Caul_3652.
    PATRICi 21320436. VBICauSp18104_4056.

    Phylogenomic databases

    eggNOGi COG3508.
    HOGENOMi HOG000139824.
    KOi K00451.
    OMAi FQSPVAC.
    OrthoDBi EOG6D5FZK.

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00339 .
    BioCyci CSP366602:GH0Y-3688-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    HAMAPi MF_00334. Homogentis_dioxygen.
    InterProi IPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR11056. PTHR11056. 1 hit.
    Pfami PF04209. HgmA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR01015. hmgA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K31.

    Entry informationi

    Entry nameiHGD_CAUSK
    AccessioniPrimary (citable) accession number: B0T816
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3