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B0T6E7

- SYL_CAUSK

UniProt

B0T6E7 - SYL_CAUSK

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Caulobacter sp. (strain K31)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei626 – 6261ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCSP366602:GH0Y-5084-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Caul_5030
    OrganismiCaulobacter sp. (strain K31)
    Taxonomic identifieri366602 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
    ProteomesiUP000001316: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 861861Leucine--tRNA ligasePRO_1000074827Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi366602.Caul_5030.

    Structurei

    3D structure databases

    ProteinModelPortaliB0T6E7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi623 – 6275"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHELEVYT.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0T6E7-1 [UniParc]FASTAAdd to Basket

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    MARYNPKDTE PKWRAAWASA NTFLTPITPD ARPKYYVLEM FPYPSGRIHM    50
    GHVRNYAMGD VVARYKRAQG FNVLHPMGWD AFGMPAENAA MERGVHPKGW 100
    TYDNIAAMRE QLKALGLSID WSREFATCDP EYYGKQQAWF LHLLKRGLVY 150
    RKEASVNWDP VDMTVLANEQ VIDGKGWRSG ATVEKRKLTQ WFLRITDYAD 200
    ALIDGLKTLD RWPEKVRIMQ ENWIGRSKGL RFTFKFDGEA PAGHADGLEV 250
    YTTRPDTLFG ASFVGIAPEH PLAEQLAAAD PAVAAFVAEC RKGGTSEADI 300
    EGAEKLGRDT GLRVVHPLDP TLTLPVWIAN FILMDYGTGA IFACPAHDQR 350
    DLDFARKYDL PVLPVVLPPG EDAATFQVGK EAYVGPGAIF NSEFLDGLDV 400
    EAAKTEAVNR IEAMDQGQGA TVYRLRDWGV SRQRYWGCPI PVIHCEACGP 450
    VGVPEDQLPV VLPDDVAFDK PGNPLLRHPT WRHTTCPSCG GKAERETDTL 500
    DTFVDSSWYF ARFTDPTAAE PISKAAADHW MPVDQYIGGV EHAVLHLLYA 550
    RFITRALKDE GLVSVEEPFA GLFTQGMVTH EAYKNAAGEW VEPSDVVIAV 600
    EGATRSARHA ATGEPITIGD IEKMSKSKKN VVAPEDIFEA YGVDAARLFV 650
    MSDSPPERDV QWTNSGVEGS WRFTHRVWNE FESQPAGDFA HDDSDAAAVA 700
    LRKGAHRLIG FVTDSIEGFR FNSGVARLYE FLNMLKAAPA EGASQGVLAA 750
    RAEALEILAR LISPFTPHLA EEAWAHLGKA GMVVDAPWPK ADAALAADDE 800
    RVLPIQINGK RRGEIKVKAG TAEAEVEKIA LADPAVLAHL EGLTVRKVIV 850
    VKDRIVNIVA G 861
    Length:861
    Mass (Da):94,852
    Last modified:April 8, 2008 - v1
    Checksum:i4626AE1743C9F46D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000927 Genomic DNA. Translation: ABZ74150.1.
    RefSeqiWP_012289019.1. NC_010338.1.
    YP_001686648.1. NC_010338.1.

    Genome annotation databases

    EnsemblBacteriaiABZ74150; ABZ74150; Caul_5030.
    GeneIDi5902492.
    KEGGicak:Caul_5030.
    PATRICi21323258. VBICauSp18104_5450.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000927 Genomic DNA. Translation: ABZ74150.1 .
    RefSeqi WP_012289019.1. NC_010338.1.
    YP_001686648.1. NC_010338.1.

    3D structure databases

    ProteinModelPortali B0T6E7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 366602.Caul_5030.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABZ74150 ; ABZ74150 ; Caul_5030 .
    GeneIDi 5902492.
    KEGGi cak:Caul_5030.
    PATRICi 21323258. VBICauSp18104_5450.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HELEVYT.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CSP366602:GH0Y-5084-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: K31.

    Entry informationi

    Entry nameiSYL_CAUSK
    AccessioniPrimary (citable) accession number: B0T6E7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3