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B0T6E7

- SYL_CAUSK

UniProt

B0T6E7 - SYL_CAUSK

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Caulobacter sp. (strain K31)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei626 – 6261ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSP366602:GH0Y-5084-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Caul_5030
OrganismiCaulobacter sp. (strain K31)
Taxonomic identifieri366602 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001316: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 861861Leucine--tRNA ligasePRO_1000074827Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi366602.Caul_5030.

Structurei

3D structure databases

ProteinModelPortaliB0T6E7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi623 – 6275"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0T6E7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARYNPKDTE PKWRAAWASA NTFLTPITPD ARPKYYVLEM FPYPSGRIHM
60 70 80 90 100
GHVRNYAMGD VVARYKRAQG FNVLHPMGWD AFGMPAENAA MERGVHPKGW
110 120 130 140 150
TYDNIAAMRE QLKALGLSID WSREFATCDP EYYGKQQAWF LHLLKRGLVY
160 170 180 190 200
RKEASVNWDP VDMTVLANEQ VIDGKGWRSG ATVEKRKLTQ WFLRITDYAD
210 220 230 240 250
ALIDGLKTLD RWPEKVRIMQ ENWIGRSKGL RFTFKFDGEA PAGHADGLEV
260 270 280 290 300
YTTRPDTLFG ASFVGIAPEH PLAEQLAAAD PAVAAFVAEC RKGGTSEADI
310 320 330 340 350
EGAEKLGRDT GLRVVHPLDP TLTLPVWIAN FILMDYGTGA IFACPAHDQR
360 370 380 390 400
DLDFARKYDL PVLPVVLPPG EDAATFQVGK EAYVGPGAIF NSEFLDGLDV
410 420 430 440 450
EAAKTEAVNR IEAMDQGQGA TVYRLRDWGV SRQRYWGCPI PVIHCEACGP
460 470 480 490 500
VGVPEDQLPV VLPDDVAFDK PGNPLLRHPT WRHTTCPSCG GKAERETDTL
510 520 530 540 550
DTFVDSSWYF ARFTDPTAAE PISKAAADHW MPVDQYIGGV EHAVLHLLYA
560 570 580 590 600
RFITRALKDE GLVSVEEPFA GLFTQGMVTH EAYKNAAGEW VEPSDVVIAV
610 620 630 640 650
EGATRSARHA ATGEPITIGD IEKMSKSKKN VVAPEDIFEA YGVDAARLFV
660 670 680 690 700
MSDSPPERDV QWTNSGVEGS WRFTHRVWNE FESQPAGDFA HDDSDAAAVA
710 720 730 740 750
LRKGAHRLIG FVTDSIEGFR FNSGVARLYE FLNMLKAAPA EGASQGVLAA
760 770 780 790 800
RAEALEILAR LISPFTPHLA EEAWAHLGKA GMVVDAPWPK ADAALAADDE
810 820 830 840 850
RVLPIQINGK RRGEIKVKAG TAEAEVEKIA LADPAVLAHL EGLTVRKVIV
860
VKDRIVNIVA G
Length:861
Mass (Da):94,852
Last modified:April 8, 2008 - v1
Checksum:i4626AE1743C9F46D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000927 Genomic DNA. Translation: ABZ74150.1.
RefSeqiWP_012289019.1. NC_010338.1.
YP_001686648.1. NC_010338.1.

Genome annotation databases

EnsemblBacteriaiABZ74150; ABZ74150; Caul_5030.
GeneIDi5902492.
KEGGicak:Caul_5030.
PATRICi21323258. VBICauSp18104_5450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000927 Genomic DNA. Translation: ABZ74150.1 .
RefSeqi WP_012289019.1. NC_010338.1.
YP_001686648.1. NC_010338.1.

3D structure databases

ProteinModelPortali B0T6E7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 366602.Caul_5030.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ74150 ; ABZ74150 ; Caul_5030 .
GeneIDi 5902492.
KEGGi cak:Caul_5030.
PATRICi 21323258. VBICauSp18104_5450.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CSP366602:GH0Y-5084-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K31.

Entry informationi

Entry nameiSYL_CAUSK
AccessioniPrimary (citable) accession number: B0T6E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3