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B0T669 (UPPP_CAUSK) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Caul_4952
OrganismCaulobacter sp. (strain K31) [Complete proteome] [HAMAP]
Taxonomic identifier366602 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000083976

Regions

Transmembrane42 – 6221Helical; Potential
Transmembrane83 – 10321Helical; Potential
Transmembrane110 – 13021Helical; Potential
Transmembrane142 – 16221Helical; Potential
Transmembrane186 – 20621Helical; Potential
Transmembrane219 – 23921Helical; Potential
Transmembrane247 – 26721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B0T669 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 5DFC14D35C7A5D28

FASTA26928,740
        10         20         30         40         50         60 
MPDWLIAIVL GLVEGLTEFI PVSSTGHLLL TKIALGLTDP AWDTFIVLIQ LGAVLGVVAL 

        70         80         90        100        110        120 
YFQRLWAVVV GLPTQPEARR FALTVLIGCI PAFAAGLALH GVIKHFFENP YLPQVICVSL 

       130        140        150        160        170        180 
ILGGVILLVV DKKAPPPREM DGMALSLKTA ALIGLFQCLS LLPGVSRSGS TIVGSMLIGV 

       190        200        210        220        230        240 
DRKAAAEFSF FMAIPIMVGA FALDLLKSYK DIDASHAGAI AIGFVVSFLS GLVVVKFLID 

       250        260 
FVGKRGFTPF AWWRIVVGVI GLGLIYIPR 

« Hide

References

[1]"Complete sequence of chromosome of Caulobacter sp. K31."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Kim E., Stephens C., Richardson P.
Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K31.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000927 Genomic DNA. Translation: ABZ74072.1.
RefSeqYP_001686570.1. NC_010338.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING366602.Caul_4952.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABZ74072; ABZ74072; Caul_4952.
GeneID5902414.
KEGGcak:Caul_4952.
PATRIC21323094. VBICauSp18104_5369.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycCSP366602:GH0Y-5005-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_CAUSK
AccessionPrimary (citable) accession number: B0T669
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: February 19, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families