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Protein

Argininosuccinate synthase

Gene

argG

Organism
Caulobacter sp. (strain K31)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei92 – 921CitrullineUniRule annotation
Binding sitei97 – 971CitrullineUniRule annotation
Binding sitei122 – 1221ATP; via amide nitrogenUniRule annotation
Binding sitei124 – 1241AspartateUniRule annotation
Binding sitei128 – 1281AspartateUniRule annotation
Binding sitei128 – 1281CitrullineUniRule annotation
Binding sitei129 – 1291AspartateUniRule annotation
Binding sitei132 – 1321CitrullineUniRule annotation
Binding sitei183 – 1831CitrullineUniRule annotation
Binding sitei192 – 1921CitrullineUniRule annotation
Binding sitei268 – 2681CitrullineUniRule annotation
Binding sitei280 – 2801CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 209ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSP366602:GH0Y-4816-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Caul_4763
OrganismiCaulobacter sp. (strain K31)
Taxonomic identifieri366602 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001316 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Argininosuccinate synthasePRO_1000073815Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi366602.Caul_4763.

Structurei

3D structure databases

ProteinModelPortaliB0T3Z9.
SMRiB0T3Z9. Positions 8-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiPAREWGM.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0T3Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKPVKKVV LAYSGGLDTS IILKWLQTEY GAEVVTFTAD LGQGEEIEPA
60 70 80 90 100
RAKALAAGVK PENIFIEDVR EEFVRDYVFP MFRANTVYEG QYLLGTSIAR
110 120 130 140 150
PLIAKKQIEI ARKVGADAVS HGATGKGNDQ VRFELGYYAL EPDIHVIAPW
160 170 180 190 200
REWDFKSREA LLDFAEKHQI QIAKDKRGEA PFSVDANLLH SSSEGKVLED
210 220 230 240 250
PAVEAPEFVH MRTIAPEDAP DKPHIFTLDF ERGDAVAIDG VAMSPATILT
260 270 280 290 300
KLNELGHDNG VGRLDLVENR FVGMKSRGVY ETPGGTILLA AHRGIESITL
310 320 330 340 350
DRGSMHLKDE LMPKYASLVY NGFWFSPERE MLQAAIDYSQ AKVAGQVRVK
360 370 380 390 400
LYKGNVSIIG RTSPYSLYDQ DLVTFEEGKV AYDHRDAGGF IKLNALRLRV

LAKRDKR
Length:407
Mass (Da):45,253
Last modified:April 7, 2008 - v1
Checksum:i54EC971064D02CB9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000927 Genomic DNA. Translation: ABZ73883.1.
RefSeqiWP_012288754.1. NC_010338.1.
YP_001686381.1. NC_010338.1.

Genome annotation databases

EnsemblBacteriaiABZ73883; ABZ73883; Caul_4763.
KEGGicak:Caul_4763.
PATRICi21322704. VBICauSp18104_5174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000927 Genomic DNA. Translation: ABZ73883.1.
RefSeqiWP_012288754.1. NC_010338.1.
YP_001686381.1. NC_010338.1.

3D structure databases

ProteinModelPortaliB0T3Z9.
SMRiB0T3Z9. Positions 8-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi366602.Caul_4763.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABZ73883; ABZ73883; Caul_4763.
KEGGicak:Caul_4763.
PATRICi21322704. VBICauSp18104_5174.

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiPAREWGM.
OrthoDBiEOG6K9QCV.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.
BioCyciCSP366602:GH0Y-4816-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K31.

Entry informationi

Entry nameiASSY_CAUSK
AccessioniPrimary (citable) accession number: B0T3Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 19, 2008
Last sequence update: April 7, 2008
Last modified: March 31, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.