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B0T3Z9

- ASSY_CAUSK

UniProt

B0T3Z9 - ASSY_CAUSK

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Caulobacter sp. (strain K31)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei92 – 921CitrullineUniRule annotation
Binding sitei97 – 971CitrullineUniRule annotation
Binding sitei122 – 1221ATP; via amide nitrogenUniRule annotation
Binding sitei124 – 1241AspartateUniRule annotation
Binding sitei128 – 1281AspartateUniRule annotation
Binding sitei128 – 1281CitrullineUniRule annotation
Binding sitei129 – 1291AspartateUniRule annotation
Binding sitei132 – 1321CitrullineUniRule annotation
Binding sitei183 – 1831CitrullineUniRule annotation
Binding sitei192 – 1921CitrullineUniRule annotation
Binding sitei268 – 2681CitrullineUniRule annotation
Binding sitei280 – 2801CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 209ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSP366602:GH0Y-4816-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:Caul_4763
OrganismiCaulobacter sp. (strain K31)
Taxonomic identifieri366602 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001316: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 407407Argininosuccinate synthasePRO_1000073815Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi366602.Caul_4763.

Structurei

3D structure databases

ProteinModelPortaliB0T3Z9.
SMRiB0T3Z9. Positions 8-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiVEEYIWR.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0T3Z9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANKPVKKVV LAYSGGLDTS IILKWLQTEY GAEVVTFTAD LGQGEEIEPA
60 70 80 90 100
RAKALAAGVK PENIFIEDVR EEFVRDYVFP MFRANTVYEG QYLLGTSIAR
110 120 130 140 150
PLIAKKQIEI ARKVGADAVS HGATGKGNDQ VRFELGYYAL EPDIHVIAPW
160 170 180 190 200
REWDFKSREA LLDFAEKHQI QIAKDKRGEA PFSVDANLLH SSSEGKVLED
210 220 230 240 250
PAVEAPEFVH MRTIAPEDAP DKPHIFTLDF ERGDAVAIDG VAMSPATILT
260 270 280 290 300
KLNELGHDNG VGRLDLVENR FVGMKSRGVY ETPGGTILLA AHRGIESITL
310 320 330 340 350
DRGSMHLKDE LMPKYASLVY NGFWFSPERE MLQAAIDYSQ AKVAGQVRVK
360 370 380 390 400
LYKGNVSIIG RTSPYSLYDQ DLVTFEEGKV AYDHRDAGGF IKLNALRLRV

LAKRDKR
Length:407
Mass (Da):45,253
Last modified:April 8, 2008 - v1
Checksum:i54EC971064D02CB9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000927 Genomic DNA. Translation: ABZ73883.1.
RefSeqiWP_012288754.1. NC_010338.1.
YP_001686381.1. NC_010338.1.

Genome annotation databases

EnsemblBacteriaiABZ73883; ABZ73883; Caul_4763.
GeneIDi5902225.
KEGGicak:Caul_4763.
PATRICi21322704. VBICauSp18104_5174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000927 Genomic DNA. Translation: ABZ73883.1 .
RefSeqi WP_012288754.1. NC_010338.1.
YP_001686381.1. NC_010338.1.

3D structure databases

ProteinModelPortali B0T3Z9.
SMRi B0T3Z9. Positions 8-402.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 366602.Caul_4763.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ73883 ; ABZ73883 ; Caul_4763 .
GeneIDi 5902225.
KEGGi cak:Caul_4763.
PATRICi 21322704. VBICauSp18104_5174.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi VEEYIWR.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci CSP366602:GH0Y-4816-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K31.

Entry informationi

Entry nameiASSY_CAUSK
AccessioniPrimary (citable) accession number: B0T3Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3