B0T1I3 (B0T1I3_CAUSK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
6,7-dimethyl-8-ribityllumazine synthase HAMAP MF_00178
Short name=DMRL synthase HAMAP MF_00178
Short name=Lumazine synthase HAMAP MF_00178
EC=2.5.1.9 HAMAP MF_00178

Alternative name(s):
Riboflavin synthase beta chain HAMAP MF_00178

Gene names

Name:	ribH HAMAP MF_00178
Ordered Locus Names:	Caul_3045

Organism

Caulobacter sp. (strain K31) [Complete proteome] [HAMAP]

Taxonomic identifier

366602 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	153 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2-butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes the condensation of 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate yielding 6,7-dimethyl-8-lumazine By similarity. HAMAP MF_00178
Catalytic activity	2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine. HAMAP MF_00178
Pathway	Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2. HAMAP MF_00178
Sequence similarities	Belongs to the DMRL synthase family. HAMAP MF_00178

Ontologies

Keywords
Biological process	Riboflavin biosynthesis HAMAP MF_00178
Molecular function	Transferase HAMAP MF_00178
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	riboflavin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	riboflavin synthase complex Inferred from electronic annotation. Source: InterPro
Molecular function	riboflavin synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B0T1I3 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: DB80942978B4F5A5	FASTA	153	16,555
	10 20 30 40 50 60 MEDKIRLLIV EARRYSGLSD ALLQGAAQAI DAQGAEYDVI TVSEAMQLPT AIAMAEEAGN 70 80 90 100 110 120 RPVGVRYDGF VALGVIIRGE TYHSEIMANE TARGLNDLSF GKRLAIGYGI VTVDEEDQAW 130 140 150 SRTRVSEGDR GGKAAQECLE IVGLKRQLLG QAR

References

[1]

"Complete sequence of chromosome of Caulobacter sp. K31." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Kim E., Stephens C., Richardson P. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K31.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000927 Genomic DNA. Translation: ABZ72172.1.
RefSeq	YP_001684670.1. NC_010338.1.
3D structure databases
ProteinModelPortal	B0T1I3.
ModBase	Search...
Protein-protein interaction databases
STRING	B0T1I3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5900500.
GenomeReviews	Gene locus Caul_3045 in contig CP000927_GR.
KEGG	cak:Caul_3045.
PATRIC	21319196. VBICauSp18104_3445.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG311126.
OMA	SSRALMD.
ProtClustDB	PRK00061.
Family and domain databases
HAMAP	MF_00178. Lumazine_synth. [Tree]
InterPro	IPR002180. DMRL_synthase. [Graphical view]
Gene3D	G3DSA:3.40.50.960. DMRL_synthase. 1 hit.
KO	K00794.
PANTHER	PTHR21058. DMRL_synthase. 1 hit.
Pfam	PF00885. DMRL_synthase. 1 hit. [Graphical view]
SUPFAM	SSF52121. DMRL_synthase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B0T1I3_CAUSK

Accession

Primary (citable) accession number: B0T1I3

Entry history

Integrated into UniProtKB/TrEMBL:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)