B0T024 (KHSE_CAUSK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homoserine kinase
Short name=HK
Short name=HSK
EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	Caul_4394

Organism

Caulobacter sp. (strain K31) [Complete proteome] [HAMAP]

Taxonomic identifier

366602 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	320 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 320	320	Homoserine kinase HAMAP MF_00301		PRO_1000079018

Sequences

	Sequence		Length	Mass (Da)
	B0T024 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 8E4AC4E394A47285	FASTA	320	34,978
	10 20 30 40 50 60 MAVYTDITDD ELAAFLGDYD LGQAVAFKGI AEGVENSNFL LETTTGRFIL TVYERRAKPE 70 80 90 100 110 120 DLPYFLDLLT WLADHGYPSA KPIADRSGAT LKTIRGKPAA LVEFLPGLSA RRPTVAHCRE 130 140 150 160 170 180 AGEGLAWLHL AGEGYPARRA NDLGQPHWAS LFSKHRKDAE GLKPGLAATI DKDLAELALA 190 200 210 220 230 240 WPRGLPSGVI HADYFPDNVF FKPDGKFAAA IDFYFACDDA YAYDIAVTLN AWCFESDGSF 250 260 270 280 290 300 NITAARALIA GYERRRPLSP AERDAIPILA RGAAMRFFLT RLADWGSTPA GALVRPKDPL 310 320 EYERKLAVHR EGLSLFGAGA

References

[1]

"Complete sequence of chromosome of Caulobacter sp. K31." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Kim E., Stephens C., Richardson P. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K31.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000927 Genomic DNA. Translation: ABZ73514.1.
RefSeq	YP_001686012.1. NC_010338.1.
3D structure databases
ProteinModelPortal	B0T024.
SMR	B0T024. Positions 5-312.
ModBase	Search...
Protein-protein interaction databases
STRING	B0T024.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5901855.
GenomeReviews	Gene locus Caul_4394 in contig CP000927_GR.
KEGG	cak:Caul_4394.
PATRIC	21321956. VBICauSp18104_4802.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ICLNAWC.
ProtClustDB	PRK05231.
Enzyme and pathway databases
BioCyc	CSP78:CAUL_4394-MONOMER.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. Aminoglycoside_PTrfase. IPR005280. Homoserine_kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
KO	K02204.
Pfam	PF01636. APH. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
TIGRFAMs	TIGR00938. ThrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_CAUSK

Accession

Primary (citable) accession number: B0T024

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 8, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program