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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Caulobacter sp. (strain K31)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Caul_4384
OrganismiCaulobacter sp. (strain K31)
Taxonomic identifieri366602 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001316 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000832181 – 453Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST453

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi366602.Caul_4384

Structurei

3D structure databases

ProteinModelPortaliB0T014
SMRiB0T014
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

B0T014-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYLPLTPED RADMLGVIGA ETIDALFVDV PAVAYRKDPV DLPFHAGELE
60 70 80 90 100
VEREMLALSR RNRSASEGPF FVGAGAYRHH VPATVDHIIQ RSEFLTSYTP
110 120 130 140 150
YQPEIAQGTL QVLFEFQTQV AALTGMEVAN ASLYDGSTAT AEAVMMATRV
160 170 180 190 200
TRRGKAVLSG GVHPHYVGTV ETLAHAAGVA TERLKAAIDA EDAVIAAIDA
210 220 230 240 250
DTACVVVQTP NVFGTATDVS KIAAAAQAAG ALLIVVTTEA VSYGLLKSPG
260 270 280 290 300
EMGADIVVAE GQSIGNGLNF GGPYVGLFAC KEKYVRQAPG RLCGETVDAD
310 320 330 340 350
GRRGFVLTLS TREQHIRRDK ATSNICTNSG LCALAFSIHM SLLGEKGLRQ
360 370 380 390 400
LALVNHHKAV KLRDALAAVP GVEVLTPRFF NEFAIKVPGN AAELVETLAA
410 420 430 440 450
NGVIGGVPFS RLDPGAGLDN VLLVAATETT PDSDIALFSK ALSKVLAPKG

SNQ
Length:453
Mass (Da):47,702
Last modified:April 8, 2008 - v1
Checksum:iF3ADFB32DA0E1647
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000927 Genomic DNA Translation: ABZ73504.1
RefSeqiWP_012288381.1, NC_010338.1

Genome annotation databases

EnsemblBacteriaiABZ73504; ABZ73504; Caul_4384
KEGGicak:Caul_4384

Similar proteinsi

Entry informationi

Entry nameiGCSPA_CAUSK
AccessioniPrimary (citable) accession number: B0T014
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health