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B0T014

- GCSPA_CAUSK

UniProt

B0T014 - GCSPA_CAUSK

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene
gcvPA, Caul_4384
Organism
Caulobacter sp. (strain K31)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciCSP366602:GH0Y-4434-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:Caul_4384
OrganismiCaulobacter sp. (strain K31)
Taxonomic identifieri366602 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001316: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 453453Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationPRO_1000083218Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi366602.Caul_4384.

Structurei

3D structure databases

ProteinModelPortaliB0T014.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiLPMHASE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

B0T014-1 [UniParc]FASTAAdd to Basket

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MRYLPLTPED RADMLGVIGA ETIDALFVDV PAVAYRKDPV DLPFHAGELE    50
VEREMLALSR RNRSASEGPF FVGAGAYRHH VPATVDHIIQ RSEFLTSYTP 100
YQPEIAQGTL QVLFEFQTQV AALTGMEVAN ASLYDGSTAT AEAVMMATRV 150
TRRGKAVLSG GVHPHYVGTV ETLAHAAGVA TERLKAAIDA EDAVIAAIDA 200
DTACVVVQTP NVFGTATDVS KIAAAAQAAG ALLIVVTTEA VSYGLLKSPG 250
EMGADIVVAE GQSIGNGLNF GGPYVGLFAC KEKYVRQAPG RLCGETVDAD 300
GRRGFVLTLS TREQHIRRDK ATSNICTNSG LCALAFSIHM SLLGEKGLRQ 350
LALVNHHKAV KLRDALAAVP GVEVLTPRFF NEFAIKVPGN AAELVETLAA 400
NGVIGGVPFS RLDPGAGLDN VLLVAATETT PDSDIALFSK ALSKVLAPKG 450
SNQ 453
Length:453
Mass (Da):47,702
Last modified:April 8, 2008 - v1
Checksum:iF3ADFB32DA0E1647
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000927 Genomic DNA. Translation: ABZ73504.1.
RefSeqiWP_012288381.1. NC_010338.1.
YP_001686002.1. NC_010338.1.

Genome annotation databases

EnsemblBacteriaiABZ73504; ABZ73504; Caul_4384.
GeneIDi5901845.
KEGGicak:Caul_4384.
PATRICi21321936. VBICauSp18104_4792.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000927 Genomic DNA. Translation: ABZ73504.1 .
RefSeqi WP_012288381.1. NC_010338.1.
YP_001686002.1. NC_010338.1.

3D structure databases

ProteinModelPortali B0T014.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 366602.Caul_4384.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ73504 ; ABZ73504 ; Caul_4384 .
GeneIDi 5901845.
KEGGi cak:Caul_4384.
PATRICi 21321936. VBICauSp18104_4792.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi LPMHASE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci CSP366602:GH0Y-4434-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K31.

Entry informationi

Entry nameiGCSPA_CAUSK
AccessioniPrimary (citable) accession number: B0T014
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 8, 2008
Last modified: September 3, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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