Reviewed, UniProtKB/Swiss-Prot B0T014 (GCSPA_CAUSK)

Names and origin

Protein names

Recommended name:
    Probable glycine dehydrogenase [decarboxylating] subunit 1
    EC=1.4.4.2
Alternative name(s):
    Glycine decarboxylase subunit 1
    Glycine cleavage system P-protein subunit 1

Gene names

Name:	gcvPA
Ordered Locus Names:	Caul_4384

Organism

Caulobacter sp. (strain K31) [Complete proteome] [HAMAP]

Taxonomic identifier

366602 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.
Catalytic activity	Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2. HAMAP MF_00712
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits By similarity.
Sequence similarities	Belongs to the gcvP family. N-terminal subunit subfamily.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine decarboxylation via glycine cleavage system Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glycine dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 453	453	Probable glycine dehydrogenase [decarboxylating] subunit 1 HAMAP MF_00712		PRO_1000083218

Sequences

	Sequence		Length	Mass (Da)
	B0T014-1 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: F3ADFB32DA0E1647	FASTA	453	47,702
	10 20 30 40 50 60 MRYLPLTPED RADMLGVIGA ETIDALFVDV PAVAYRKDPV DLPFHAGELE VEREMLALSR 70 80 90 100 110 120 RNRSASEGPF FVGAGAYRHH VPATVDHIIQ RSEFLTSYTP YQPEIAQGTL QVLFEFQTQV 130 140 150 160 170 180 AALTGMEVAN ASLYDGSTAT AEAVMMATRV TRRGKAVLSG GVHPHYVGTV ETLAHAAGVA 190 200 210 220 230 240 TERLKAAIDA EDAVIAAIDA DTACVVVQTP NVFGTATDVS KIAAAAQAAG ALLIVVTTEA 250 260 270 280 290 300 VSYGLLKSPG EMGADIVVAE GQSIGNGLNF GGPYVGLFAC KEKYVRQAPG RLCGETVDAD 310 320 330 340 350 360 GRRGFVLTLS TREQHIRRDK ATSNICTNSG LCALAFSIHM SLLGEKGLRQ LALVNHHKAV 370 380 390 400 410 420 KLRDALAAVP GVEVLTPRFF NEFAIKVPGN AAELVETLAA NGVIGGVPFS RLDPGAGLDN 430 440 450 VLLVAATETT PDSDIALFSK ALSKVLAPKG SNQ

References

[1]

"Complete sequence of chromosome of Caulobacter sp. K31." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Kim E., Stephens C., Richardson P. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000927 Genomic DNA. Translation: ABZ73504.1.
RefSeq	YP_001686002.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5901845.
GenomeReviews	Gene locus Caul_4384 in contig CP000927_GR.
KEGG	cak:Caul_4384.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	B0T014. VANASMY.
Family and domain databases
HAMAP	MF_00712. [Tree]
InterPro	IPR003437. GDC-P. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11773. GDC-P. 1 hit.
Pfam	PF02347. GDC-P. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCSPA_CAUSK

Accession

Primary (citable) accession number: B0T014

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 8, 2008
Last modified:	June 16, 2009
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)