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B0SZ02

- SYE_CAUSK

UniProt

B0SZ02 - SYE_CAUSK

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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Caulobacter sp. (strain K31)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei247 – 2471ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCSP366602:GH0Y-2803-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Caul_2786
OrganismiCaulobacter sp. (strain K31)
Taxonomic identifieri366602 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
ProteomesiUP000001316: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Glutamate--tRNA ligasePRO_0000367644Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi366602.Caul_2786.

Structurei

3D structure databases

ProteinModelPortaliB0SZ02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi18 – 2811"HIGH" regionAdd
BLAST
Motifi244 – 2485"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000252722.
KOiK01885.
OMAiNDYNQLE.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0SZ02-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTNSPAPTTS GVVTRFAPSP TGFLHIGGAR TALFNWLYAR HTGGKFLVRV
60 70 80 90 100
EDTDRERSTQ AAVAAIFEGL DWLGMKSDEE VVFQHKKADR HREAVQQLLD
110 120 130 140 150
TGRAYRCWMS VEDLALAREA ARAGGPALRS PWRDAPPPND PTAPHVIRFK
160 170 180 190 200
GPLDGTTLVD DLVKGPVTFD NAELDDLVLL RADGAPTYNL AVVVDDHDMG
210 220 230 240 250
VTHVIRGDDH LNNAARQTLI YQAMGWTLPA FGHIPLIHGP DGAKLSKRHG
260 270 280 290 300
AQAVGEFQDM GYLPEGLRNY LARLGWGHGD DEVFSDAQAI EWFDVKDVVK
310 320 330 340 350
APARLDWAKL NFINSQHLHV AEDGRLADLT LKALQAQGAP LPDDAPARLL
360 370 380 390 400
ATVPQVKVGA KTILELAEHC AFALKVRPLA LEEKTRNQLT DETVDRLKRL
410 420 430 440 450
RAQLGAVPVW GLSELEVLLK SFAESEGVGF GKFGPSLRGI LTGGSQAPDL
460 470
NKIMTALGRE ESLGRLDDAL ASRA
Length:474
Mass (Da):51,637
Last modified:April 8, 2008 - v1
Checksum:iDE0F0108389F9089
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000927 Genomic DNA. Translation: ABZ71913.1.
RefSeqiWP_012286815.1. NC_010338.1.
YP_001684411.1. NC_010338.1.

Genome annotation databases

EnsemblBacteriaiABZ71913; ABZ71913; Caul_2786.
GeneIDi5900241.
KEGGicak:Caul_2786.
PATRICi21318648. VBICauSp18104_3181.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000927 Genomic DNA. Translation: ABZ71913.1 .
RefSeqi WP_012286815.1. NC_010338.1.
YP_001684411.1. NC_010338.1.

3D structure databases

ProteinModelPortali B0SZ02.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 366602.Caul_2786.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ71913 ; ABZ71913 ; Caul_2786 .
GeneIDi 5900241.
KEGGi cak:Caul_2786.
PATRICi 21318648. VBICauSp18104_3181.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000252722.
KOi K01885.
OMAi NDYNQLE.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci CSP366602:GH0Y-2803-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K31.

Entry informationi

Entry nameiSYE_CAUSK
AccessioniPrimary (citable) accession number: B0SZ02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3