Reviewed, UniProtKB/Swiss-Prot B0SYU7 (HUTI_CAUSK)

Names and origin

Protein names

Recommended name:
    Imidazolonepropionase
    EC=3.5.2.7
Alternative name(s):
    Imidazolone-5-propionate hydrolase

Gene names

Name:	hutI
Ordered Locus Names:	Caul_1298

Organism

Caulobacter sp. (strain K31) [Complete proteome] [HAMAP]

Taxonomic identifier

366602 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Caulobacterales › Caulobacteraceae › Caulobacter

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+. HAMAP MF_00372
Cofactor	Binds 1 zinc or iron ion per subunit By similarity. HAMAP MF_00372
Pathway	Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. HAMAP MF_00372
Subcellular location	Cytoplasm Potential HAMAP MF_00372.
Sequence similarities	Belongs to the hutI family.

Ontologies

Keywords
Biological process	Histidine metabolism
Cellular component	Cytoplasm
Ligand	Iron Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine catabolic process to glutamate and formamide Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	imidazolonepropionase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 401	401	Imidazolonepropionase HAMAP MF_00372		PRO_1000079821
Sites
	Metal binding	70	1	Zinc or iron By similarity
	Metal binding	72	1	Zinc or iron By similarity
	Metal binding	240	1	Zinc or iron By similarity
	Metal binding	315	1	Zinc or iron By similarity
	Binding site	79	1	Substrate By similarity
	Binding site	92	1	Substrate By similarity
	Binding site	142	1	Substrate By similarity
	Binding site	175	1	Substrate By similarity
	Binding site	243	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0SYU7-1 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: FEFFCF6033706BB3	FASTA	401	42,469
	10 20 30 40 50 60 MRCDRVWSKA RLATFAAGRP GIGVVEDGVV ASLSGRIVYA GPATEAPAFE ALETLDCEGR 70 80 90 100 110 120 WITPGLIDPH THLVFGGDRA REFELRLAGA TYEEIARAGG GIVSTMKATR AASEGELVAS 130 140 150 160 170 180 ALPRLDALIA EGLTTIEIKS GYGLSLDDEL KSLRAARALA DVRKVSVTTT FLGAHALPPE 190 200 210 220 230 240 YEGDPDGYID HVCYQMIPAV AAEGLADAVD AFCEGIGFSR AQTRRVFQAA RERGLPVKLH 250 260 270 280 290 300 AEQLSNLDGA ALAAEFGALS ADHLEHLDGA GIAAMAQAGT TAVLLPGAFY FVRETRLPPI 310 320 330 340 350 360 QALRAAGVPL ALATDCNPGT SPLTSLLLTL NMAATLFRMT VDECLAGVTR EAARAIGRLD 370 380 390 400 HIGTLEAGKS CDLAIWDIER PAQLVYRMGF NPLHARVWKG L

References

[1]

"Complete sequence of chromosome of Caulobacter sp. K31." Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Bruce D., Goodwin L., Thompson L.S., Brettin T., Detter J.C., Han C., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Kim E., Stephens C., Richardson P. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000927 Genomic DNA. Translation: ABZ70428.1.
RefSeq	YP_001682926.1.
3D structure databases
SMR	B0SYU7. Positions 6-400.
ModBase	Search...
Genome annotation databases
GeneID	5898753.
GenomeReviews	Gene locus Caul_1298 in contig CP000927_GR.
KEGG	cak:Caul_1298.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG686142.
OMA	MNMACTL.
Family and domain databases
HAMAP	MF_00372. HutI. [Tree]
InterPro	IPR013108. Amidohydro_3. IPR005920. HutI. IPR011059. Metal-dep_hydrolase_composite. [Graphical view]
Pfam	PF07969. Amidohydro_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR01224. hutI. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HUTI_CAUSK

Accession

Primary (citable) accession number: B0SYU7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 8, 2008
Last modified:	February 9, 2010
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)