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Protein

Catalase-peroxidase

Gene

katG

Organism
Caulobacter sp. (strain K31)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei99Transition state stabilizerUniRule annotation1
Active sitei103Proton acceptorUniRule annotation1
Metal bindingi266Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:Caul_1076
OrganismiCaulobacter sp. (strain K31)
Taxonomic identifieri366602 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaCaulobacteralesCaulobacteraceaeCaulobacter
Proteomesi
  • UP000001316 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003547541 – 737Catalase-peroxidaseAdd BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki102 ↔ 225Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-251)UniRule annotation
Cross-linki225 ↔ 251Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-102)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiB0SX45.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi366602.Caul_1076.

Structurei

3D structure databases

ProteinModelPortaliB0SX45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0SX45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGSELVEPT TKCPLKHGVR FHTSFGGRSN RDWWPNQLNL KILHQHAPAS
60 70 80 90 100
NPMPAGFSYA EQVETLDVEA LKRDLAALMT DSQDWWPADY GHYGPLFVRM
110 120 130 140 150
AWHSAGTYRT GDGRGGAGGG QQRFAPLNSW PDNGNLDKAR RLIWPIKQKY
160 170 180 190 200
GARISWADLM ILAADVGMET MGFKTFGFGF GREDTWEPEE DVHWGAEDTW
210 220 230 240 250
LGDARYTGER ELDKPLGAVQ MGLIYVNPEG PNGKPDPLAA AHDIRETFAR
260 270 280 290 300
MAMNDEETVA LIAGGHTFGK AHGAGDAAHV GVEPEAAGIA LQGLGWKNSF
310 320 330 340 350
GSGVGSDAIT SGLEGPWTPN PIKWDNGFFD TLFGHEWELT KSPAGAFQWT
360 370 380 390 400
PKDPEAGPKA PDAHDPSRQV APMMLTTDLA LRLDPNYGPI SKRFHENPDQ
410 420 430 440 450
FQDAFARAWF KLTHRDMGPK ARYLGPLVPQ EELLWQDPLP EPQGPPIDAN
460 470 480 490 500
DIRELKAKVL ATGLSVPQLV ATAWASASTF RGSDKRGGAN GARIRLSPQK
510 520 530 540 550
DWAVNQPAQL ANVLATLEGV QSAFNGGQTD GKTVSLADLI VLAGCAAVEQ
560 570 580 590 600
AAKAAGHDVE VPFTPGRVDA SQNQTDVASF GVLEPKADGF RNYLNTDLPL
610 620 630 640 650
TAEELLVDKA QLLTLSAPEM TVLVGGLRAL NANTDQSSHG VFTTRPGSLT
660 670 680 690 700
NDFFVNLLDM RTVWTATSED EAQFEGRDRT TGDLKWTATR VDLIFGSNSQ
710 720 730
LRALAEVFAQ SDSQGAFVGA FVAAWTKVMN LDRFDLA
Length:737
Mass (Da):80,080
Last modified:April 8, 2008 - v1
Checksum:i4DEB2F28BBDB11E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000927 Genomic DNA. Translation: ABZ70206.1.
RefSeqiWP_012285138.1. NC_010338.1.

Genome annotation databases

EnsemblBacteriaiABZ70206; ABZ70206; Caul_1076.
KEGGicak:Caul_1076.
PATRICi21315158. VBICauSp18104_1448.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000927 Genomic DNA. Translation: ABZ70206.1.
RefSeqiWP_012285138.1. NC_010338.1.

3D structure databases

ProteinModelPortaliB0SX45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi366602.Caul_1076.

Proteomic databases

PRIDEiB0SX45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABZ70206; ABZ70206; Caul_1076.
KEGGicak:Caul_1076.
PATRICi21315158. VBICauSp18104_1448.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OMAiIAEVYAC.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_CAUSK
AccessioniPrimary (citable) accession number: B0SX45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: April 8, 2008
Last modified: November 2, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.