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B0STJ3

- SYL_LEPBP

UniProt

B0STJ3 - SYL_LEPBP

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei641 – 6411ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLBIF456481:GCM0-262-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:LEPBI_I0262
    OrganismiLeptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
    Taxonomic identifieri456481 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
    ProteomesiUP000001847: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 867867Leucine--tRNA ligasePRO_1000091332Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi456481.LEPBI_I0262.

    Structurei

    3D structure databases

    ProteinModelPortaliB0STJ3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi638 – 6425"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0STJ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNYPFQDIEQ KWQKYWDHHQ TFRTNTHSSK PKYYCLDMFP YPSGAGLHVG    50
    HPEGYTATDI ISRLKRMEGY EVLHPMGWDA FGLPAERYAM TTGIHPRTTT 100
    KNNIDTFRRQ IKSLGLSYDW EREISTTHPD YYRWTQWIFL QIYNSYFDRK 150
    QNKAVPITTL IQTLEREGSL FFEGVELPKG IQFTASEWKS KSRKEKEDIL 200
    SHFRLVYEAN IPVNWCEALG TVLANEEVEE WTSKGYSVER KPMRQYMMRI 250
    TAYAERLLND LSLCEWPPST LEMQRNWIGK SEGLELSFHV PSLNKDITVY 300
    TTRPDTIFGA TYLVLAPEHA LVAELTTPEQ TEAVGQYQKD CSLKSDLERT 350
    ELNKDKTGVF TGAYAQLPTD PSVKVPIYIS DYVLISYGTG AIMAVPAHDQ 400
    RDYDFAVKFN LPIKQVIDGK METNLAFDSK DSVCINSSSA EVQLDGKSYK 450
    DAFQTMVVWA EKKGIGRKKI QFKLRDWLFA RQRYWGEPIP LVHFEDGSPK 500
    ALSDSELPLV LPDLEEFKPS GTGESPLALA KDWLVYKDPE TGEIGKRETN 550
    TMPQWAGSCY YYLRYIDPRN NDKLIDPELE KMWMPVEVYV GGAEHAVLHL 600
    LYSRFWHKIL FDLGHVSTPE PFKKLVHQGL ILGEDKGKMS KSRGNVVNPD 650
    DVVSEFGADT LRLFEMFMGP FEMSKPWSKN GVDGVFRFLN RVWRLFHSGE 700
    NESFFVEDIE PNEAEQKTLH RTIKKVKDDI DSFSFNTAVS QMMIFINEFT 750
    SNPRKPKQVL EPFVLALSPF APHLAEELWA KLGHTDSLAY HPYPKWDEKY 800
    LIDANITIVV QVNGKMRGEF LAPREIEEKE ALSLAKEVEK AKPFWVGKEI 850
    KKEIYVKGKL VNIVVAG 867
    Length:867
    Mass (Da):99,943
    Last modified:April 8, 2008 - v1
    Checksum:iB2315D585FBDB924
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000786 Genomic DNA. Translation: ABZ96407.1.
    RefSeqiWP_012387295.1. NC_010602.1.
    YP_001837683.1. NC_010602.1.

    Genome annotation databases

    EnsemblBacteriaiABZ96407; ABZ96407; LEPBI_I0262.
    GeneIDi6222138.
    KEGGilbi:LEPBI_I0262.
    PATRICi22347220. VBILepBif123590_0264.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000786 Genomic DNA. Translation: ABZ96407.1 .
    RefSeqi WP_012387295.1. NC_010602.1.
    YP_001837683.1. NC_010602.1.

    3D structure databases

    ProteinModelPortali B0STJ3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 456481.LEPBI_I0262.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABZ96407 ; ABZ96407 ; LEPBI_I0262 .
    GeneIDi 6222138.
    KEGGi lbi:LEPBI_I0262.
    PATRICi 22347220. VBILepBif123590_0264.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci LBIF456481:GCM0-262-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis."
      Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N., Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A., Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L., Rood J.I., Lajus A.
      , Davies J.K., Medigue C., Adler B.
      PLoS ONE 3:E1607-E1607(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Patoc 1 / ATCC 23582 / Paris.

    Entry informationi

    Entry nameiSYL_LEPBP
    AccessioniPrimary (citable) accession number: B0STJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3