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B0SSU3

- PGK_LEPBP

UniProt

B0SSU3 - PGK_LEPBP

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361SubstrateUniRule annotation
    Binding sitei118 – 1181SubstrateUniRule annotation
    Binding sitei151 – 1511SubstrateUniRule annotation
    Binding sitei201 – 2011ATPUniRule annotation
    Binding sitei292 – 2921ATP; via carbonyl oxygenUniRule annotation
    Binding sitei323 – 3231ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi349 – 3524ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLBIF456481:GCM0-2068-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
    Gene namesi
    Name:pgkUniRule annotation
    Ordered Locus Names:LEPBI_I2081
    OrganismiLeptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
    Taxonomic identifieri456481 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
    ProteomesiUP000001847: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396Phosphoglycerate kinasePRO_1000096354Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi456481.LEPBI_I2081.

    Structurei

    3D structure databases

    ProteinModelPortaliB0SSU3.
    SMRiB0SSU3. Positions 1-392.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 233Substrate bindingUniRule annotation
    Regioni59 – 624Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227107.
    KOiK00927.
    OMAiAGHPVGK.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0SSU3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLPLLEEQN LKGKRVFVRV DFNVPVENGK ATDRTRIEKT LPTLELLISK    50
    GAKIILGSHL GRPKGGPEPK YSMKPVFDVL SELVKTKVSF SESVIGSDVV 100
    KMTNALGEGE ILLLENLRFH KEEEENVASF CKELAKLADV YVNDAFGTAH 150
    RAHASTEGVA HLLPAFAGLL MRKEIEVLSG LLAKPERPFV AIVGGSKVSS 200
    KFAILKNLLE KVDHLLIGGG MAYTFLKSRA VPVGKSLVEP EFESQAFQLI 250
    DRAGIQGVDL QIPVDHIIAD AFDPNAKTKS VDKMGIIDGW MGMDIGPKTI 300
    DNYVKAIKDA KTILWNGPMG VFEMDKFSKG TIEIAKAISK SKAKTVVGGG 350
    DSIAAVNKAG VADKITHIST GGGASLEFLE GRTLPGVQCL LPKEEK 396
    Length:396
    Mass (Da):42,739
    Last modified:April 8, 2008 - v1
    Checksum:i5AE0ECF02239D1C4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000786 Genomic DNA. Translation: ABZ98183.1.
    RefSeqiYP_001839459.1. NC_010602.1.

    Genome annotation databases

    EnsemblBacteriaiABZ98183; ABZ98183; LEPBI_I2081.
    GeneIDi6223070.
    KEGGilbi:LEPBI_I2081.
    PATRICi22351000. VBILepBif123590_2126.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000786 Genomic DNA. Translation: ABZ98183.1 .
    RefSeqi YP_001839459.1. NC_010602.1.

    3D structure databases

    ProteinModelPortali B0SSU3.
    SMRi B0SSU3. Positions 1-392.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 456481.LEPBI_I2081.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABZ98183 ; ABZ98183 ; LEPBI_I2081 .
    GeneIDi 6223070.
    KEGGi lbi:LEPBI_I2081.
    PATRICi 22351000. VBILepBif123590_2126.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227107.
    KOi K00927.
    OMAi AGHPVGK.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci LBIF456481:GCM0-2068-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis."
      Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N., Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A., Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L., Rood J.I., Lajus A.
      , Davies J.K., Medigue C., Adler B.
      PLoS ONE 3:E1607-E1607(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Patoc 1 / ATCC 23582 / Paris.

    Entry informationi

    Entry nameiPGK_LEPBP
    AccessioniPrimary (citable) accession number: B0SSU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3