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B0SS37 (UPPP_LEPBP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:LEPBI_I1821
OrganismLeptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris) [Complete proteome] [HAMAP]
Taxonomic identifier456481 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000197380

Regions

Transmembrane17 – 3721Helical; Potential
Transmembrane46 – 6621Helical; Potential
Transmembrane92 – 11221Helical; Potential
Transmembrane123 – 14321Helical; Potential
Transmembrane156 – 17621Helical; Potential
Transmembrane197 – 21721Helical; Potential
Transmembrane226 – 24621Helical; Potential
Transmembrane257 – 27721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B0SS37 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: AA8B2A0100904E49

FASTA27931,616
        10         20         30         40         50         60 
MDNTLNAFLR GIIEAATEFL PVSSTGHLFL FSYFFPFQNL SVPHEAFEDL FDIFIQTGAI 

        70         80         90        100        110        120 
LSVVVLYYKT LWSHLVEAVR FGLGKSTDRS GFQFYLNLIV GILPILILGF LLKSQLDQIK 

       130        140        150        160        170        180 
MRSDLLLILG MSWFVGGIIM VFVEKRHLDE SSGKTIGFKE SIIVGFLQCF ALIPGVSRSA 

       190        200        210        220        230        240 
ATIISARTMG VSKKDSAEFS FFLAIPVLTL AGIYKLYKHR QILNSETIGL LLFGSIISFI 

       250        260        270 
ICYFIIRLFM AFIRRRSFIS FGVYRILLGL LVILYFVRY 

« Hide

References

[1]"Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis."
Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N., Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A., Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L., Rood J.I., Lajus A. expand/collapse author list , Davies J.K., Medigue C., Adler B.
PLoS ONE 3:E1607-E1607(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Patoc 1 / ATCC 23582 / Paris.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000786 Genomic DNA. Translation: ABZ97927.1.
RefSeqYP_001839203.1. NC_010602.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING456481.LEPBI_I1821.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABZ97927; ABZ97927; LEPBI_I1821.
GeneID6222052.
KEGGlbi:LEPBI_I1821.
PATRIC22350466. VBILepBif123590_1864.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycLBIF456481:GCM0-1807-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_LEPBP
AccessionPrimary (citable) accession number: B0SS37
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families