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B0SM82 (B0SM82_LEPBP) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptide methionine sulfoxide reductase MsrA 1 HAMAP MF_01401
Short name=Protein-methionine-S-oxide reductase 1 HAMAP MF_01401
EC=1.8.4.11 HAMAP MF_01401
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 1 HAMAP MF_01401
Gene names
Name:msrA2 EMBL ABZ98712.1
Synonyms:msrA1 HAMAP MF_01401
Ordered Locus Names:LEPBI_I2633
OrganismLeptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris) [Complete proteome] [HAMAP] EMBL ABZ98712.1
Taxonomic identifier456481 [NCBI]
Taxonomic lineageBacteria › Spirochaetes › Spirochaetales › Leptospiraceae › Leptospira

Protein attributes

Sequence length227 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401

Catalytic activity

L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401

Sequence similarities

Belongs to the MsrA Met sulfoxide reductase family. HAMAP MF_01401

Ontologies

Keywords
   Molecular functionOxidoreductase HAMAP MF_01401 EMBL ABZ98712.1
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processprotein modification process

Inferred from electronic annotation. Source: HAMAP

   Molecular functionpeptide-methionine-(S)-S-oxide reductase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site571 By similarity HAMAP MF_01401

Sequences

Sequence LengthMass (Da)Tools
B0SM82 [UniParc].

Last modified April 8, 2008. Version 1.
Checksum: 1408CB44947E5C89

FASTA22725,792
        10         20         30         40         50         60 
MIGLDCLFGK KLVPLAIFGL AFVLFPFCGP VTQISKQESL PLVPKSGQKI AVFAEGCFWC 

        70         80         90        100        110        120 
SEHIFESIPG VIDVVSGYAG GHTENPTYES VNTEMTGHAE SVYIVYDPTK ISYAELCRIF 

       130        140        150        160        170        180 
FLSHDPTTKD RQGPDIGSSY RSILFYADEE EFKIANTIKK EIQTQNIWNG TIVTEFQKLK 

       190        200        210        220 
HFYKAEGYHQ DFIKNNPSQS YVLAVSIPRF KEFQNRYNEF KTRKTVP

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References

[1]"Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis."
Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N., Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A., Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L., Rood J.I., Lajus A. expand/collapse author list , Davies J.K., Medigue C., Adler B.
PLoS ONE 3:E1607-E1607(2008) [PubMed: 18270594] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Patoc 1 EMBL ABZ98712.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000786 Genomic DNA. Translation: ABZ98712.1.
RefSeqYP_001839988.1. NC_010602.1.

3D structure databases

ProteinModelPortalB0SM82.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0SM82.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6222433.
GenomeReviewsGene locus LEPBI_I2633 in contig CP000786_GR.
KEGGlbi:LEPBI_I2633.
PATRIC22352067. VBILepBif123590_2653.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG748152.
OMAKIEYDVA.
ProtClustDBCLSK2336929.

Family and domain databases

HAMAPMF_01401. MsrA.
[Tree]
InterProIPR002569. Peptide_Met_Sox_Rdtase_MsrA.
[Graphical view]
Gene3DG3DSA:3.30.1060.10. MsrA. 1 hit.
KOK07304.
PfamPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMSSF55068. MsrA. 1 hit.
TIGRFAMsTIGR00401. MsrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB0SM82_LEPBP
AccessionPrimary (citable) accession number: B0SM82
Entry history
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info