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Protein

Pyruvate kinase

Gene

pykF

Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. Phosphoglycerate mutase (2,3-diphosphoglycerate-independent) (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (pykF), Pyruvate kinase (pykF)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciLBIF456481:G1G9P-759-MONOMER
UniPathwayiUPA00109; UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:pykFImported
Ordered Locus Names:LEPBI_I0764Imported
OrganismiLeptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)Imported
Taxonomic identifieri456481 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira
Proteomesi
  • UP000001847 Componenti: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi456481.LEPBI_I0764

Structurei

3D structure databases

ProteinModelPortaliB0SL88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 342PKInterPro annotationAdd BLAST333
Domaini364 – 475PK_CInterPro annotationAdd BLAST112

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CA9 Bacteria
COG0469 LUCA
HOGENOMiHOG000021558
KOiK00873
OMAiICVEAEK
OrthoDBiPOG091H02AT

Family and domain databases

Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR018209 Pyrv_Knase_AS
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 2 hits
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
PROSITEiView protein in PROSITE
PS00110 PYRUVATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

B0SL88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEDLKIPKK RTKIICTIGP ASANRETILN LIYAGMDLAR MNFSHSTHEY
60 70 80 90 100
HKEIFELLRE CEQESGKSIG ILADLQGPKI RTGKLGAGTI ELKAGDQIAI
110 120 130 140 150
NNKGDFLGNR DEIGCTYQYI LNDIDVGHKI LIDDGKLAFV VKSKSKEKAI
160 170 180 190 200
LETVIGGVLK DNKGINLPGT PISAPALSEK DIEDLQFALS LGVDYIALSF
210 220 230 240 250
VRRANDLEMA RQFMKDSYAG LIAKIERPEA IQNIEEIIDH CDGIMIARGD
260 270 280 290 300
LGVELDTQYV PIIQKEMITK LNQRGKPVIT ATQMLETMID NPRPTRAEAS
310 320 330 340 350
DVANAVMDGT DAVMLSGETA SGKYPVETVK TMTSIIQAAE ESEIYLSHLR
360 370 380 390 400
SMNRTEFEVE RTALGSAAES ISRSIHAKAI INFTRSGYSS LLSSEFRPLN
410 420 430 440 450
PIYSFTPFLG TARKMQLFWG VESYVMPMMD KFPDMIAFMS KTLKSEGKLK
460 470
SGDTVVILSG APGSVAQTVD FIQIHKIK
Length:478
Mass (Da):52,692
Last modified:April 8, 2008 - v1
Checksum:iB69CF45DEF3E1116
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000786 Genomic DNA Translation: ABZ96895.1
RefSeqiWP_012387782.1, NC_010602.1

Genome annotation databases

EnsemblBacteriaiABZ96895; ABZ96895; LEPBI_I0764
GeneIDi35829019
KEGGilbi:LEPBI_I0764

Similar proteinsi

Entry informationi

Entry nameiB0SL88_LEPBP
AccessioniPrimary (citable) accession number: B0SL88
Entry historyiIntegrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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