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Protein

Beta-galactosidase

Gene

LEPBI_I0024

Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei103 – 1031SubstrateUniRule annotation
Metal bindingi107 – 1071ZincUniRule annotation
Binding sitei141 – 1411SubstrateUniRule annotation
Active sitei142 – 1421Proton donorUniRule annotation
Active sitei304 – 3041NucleophileUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationImported, Hydrolase

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciLBIF456481:GCM0-24-MONOMER.

Protein family/group databases

CAZyiGH42. Glycoside Hydrolase Family 42.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidaseUniRule annotation (EC:3.2.1.23UniRule annotation)
Short name:
Beta-galUniRule annotation
Gene namesi
Ordered Locus Names:LEPBI_I0024Imported
OrganismiLeptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)Imported
Taxonomic identifieri456481 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000001847 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi456481.LEPBI_I0024.

Structurei

3D structure databases

ProteinModelPortaliB0SK30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 42 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1874.
HOGENOMiHOG000117811.
KOiK12308.
OMAiMWHRDKD.
OrthoDBiEOG6HMX9F.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR013738. Beta_galactosidase_Trimer.
IPR029062. Class_I_gatase-like.
IPR003476. Glyco_hydro_42.
IPR013529. Glyco_hydro_42_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02449. Glyco_hydro_42. 1 hit.
PF08532. Glyco_hydro_42M. 1 hit.
[Graphical view]
PIRSFiPIRSF001084. B-galactosidase. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52317. SSF52317. 1 hit.

Sequencei

Sequence statusi: Complete.

B0SK30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIFGACYYPE QWNPKDWDED LKMMKEMGLS SVRLAEFAWG IMEPKEGKFD
60 70 80 90 100
FSLFDAILEK IQKQGMTAIL GTPTATFPPW LYQKFPEIVQ ISKEGIIRGI
110 120 130 140 150
GTRRQACFSS PAYKKATERI VTAMAKHFGN HPAVVGWQID NEPGHEGSDV
160 170 180 190 200
DYSPLAEKNF RIWLKTKYKT LDSLNKRWGN VFWGVIYSDW NQIPLPGAHV
210 220 230 240 250
ASNFNPAMIQ DYYRFQSDEL VSYIHFQAEI LRKYSKGKPL TTNLYPSPFL
260 270 280 290 300
PVTDMYEMFK KLDYVSWDNY PVWGNQQEPY PHPLVTATQQ YSRGLKDKPY
310 320 330 340 350
TVMEQFSGVQ GHDTLGYLPP PGQIGLWLTQ AIVNGANQIY FFRYRTARFG
360 370 380 390 400
QEQLCYGILD HGKRKTSKYF ELKKTIEEIK EFAEDIAASP YPAKVAILHD
410 420 430 440 450
IENSRNYKHQ PLSDGLKFSP VPFAQVGYDI ELATWFAGTN VLNVNTHSLP
460 470 480 490 500
IQREQDWSNY KVLTLPLYTM FGPEIVEKLK AYVQEGGTLV LGYRSGIKDK
510 520 530 540 550
DHWMVEEPVP GVFSEMAGVE VFQFEAPATD KVGIKMGIWP LKGSKFCEIL
560 570 580 590 600
EPTSAKVIAR YRDKKKFYSG KPAITVNSFG KGKVYYVGTS LTPESFVLLY
610 620 630 640 650
RKILKGAGIP FGFLGATIER HFREGKKYNY EITMNHSNQY KLAGFSVLKP
660
FGYQIKRIQK
Length:660
Mass (Da):75,646
Last modified:April 8, 2008 - v1
Checksum:i8619CAC0AAA94AA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000786 Genomic DNA. Translation: ABZ96171.1.
RefSeqiWP_012387062.1. NC_010602.1.
YP_001837447.1. NC_010602.1.

Genome annotation databases

EnsemblBacteriaiABZ96171; ABZ96171; LEPBI_I0024.
KEGGilbi:LEPBI_I0024.
PATRICi22346740. VBILepBif123590_0025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000786 Genomic DNA. Translation: ABZ96171.1.
RefSeqiWP_012387062.1. NC_010602.1.
YP_001837447.1. NC_010602.1.

3D structure databases

ProteinModelPortaliB0SK30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi456481.LEPBI_I0024.

Protein family/group databases

CAZyiGH42. Glycoside Hydrolase Family 42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABZ96171; ABZ96171; LEPBI_I0024.
KEGGilbi:LEPBI_I0024.
PATRICi22346740. VBILepBif123590_0025.

Phylogenomic databases

eggNOGiCOG1874.
HOGENOMiHOG000117811.
KOiK12308.
OMAiMWHRDKD.
OrthoDBiEOG6HMX9F.

Enzyme and pathway databases

BioCyciLBIF456481:GCM0-24-MONOMER.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR013738. Beta_galactosidase_Trimer.
IPR029062. Class_I_gatase-like.
IPR003476. Glyco_hydro_42.
IPR013529. Glyco_hydro_42_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02449. Glyco_hydro_42. 1 hit.
PF08532. Glyco_hydro_42M. 1 hit.
[Graphical view]
PIRSFiPIRSF001084. B-galactosidase. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52317. SSF52317. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis."
    Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N., Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A., Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L., Rood J.I., Lajus A.
    , Davies J.K., Medigue C., Adler B.
    PLoS ONE 3:E1607-E1607(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Patoc 1 / ATCC 23582 / ParisImported.

Entry informationi

Entry nameiB0SK30_LEPBP
AccessioniPrimary (citable) accession number: B0SK30
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: April 1, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.