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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei310UniRule annotation1
Active sitei424UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:LEPBI_I0074
OrganismiLeptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
Taxonomic identifieri456481 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira
Proteomesi
  • UP000001847 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001257371 – 450Glucose-6-phosphate isomeraseAdd BLAST450

Interactioni

Protein-protein interaction databases

STRINGi456481.LEPBI_I0074

Structurei

3D structure databases

ProteinModelPortaliB0SJQ8
SMRiB0SJQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYV Bacteria
COG0166 LUCA
HOGENOMiHOG000100403
KOiK01810
OMAiVERCKAM
OrthoDBiPOG091H0EIM

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

B0SJQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNLKISDRF VKPFLDQSKL EKELERAEMA RQTVLNGSGL GNEFLGWVNL
60 70 80 90 100
PSQTKAEDLQ NIRKAAELIQ SHSQYLVVVG IGGSYLGARA VIEALTPEFS
110 120 130 140 150
TPETQKKTVK ILYAGHHLDA DYHFRLLAFL ENKEFSVNVI SKSGTTTEPA
160 170 180 190 200
IAFRLLLSLL ERKYGKENIK HRVFATTDRS KGALKHLADE YKFPTFVIPD
210 220 230 240 250
DVGGRYSVFT PVGLLPIAAA GFSINKLMDG AKQMESELKS TASKDGNLAC
260 270 280 290 300
FYAAIRNGLY SLGKTTEIFV SYNPSFGYVS EWWKQLFGES EGKNGKGIFP
310 320 330 340 350
ASVQFTTDLH SMGQYIQDGE RKLMETVIKV EAPKQDVYLT EKTDDNDGLN
360 370 380 390 400
YLAGKKLSEV NQSAMLGTLI AHKDGGVPCL EITLPSINEE TLGELLYFYE
410 420 430 440 450
FSCAVSGYML GVNPFDQPGV EDYKNNMFAL LGKKGYEKRK EEILSHLGFS
Length:450
Mass (Da):50,024
Last modified:April 8, 2008 - v1
Checksum:i835B6BA3CF58CF34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000786 Genomic DNA Translation: ABZ96221.1
RefSeqiWP_012387111.1, NC_010602.1

Genome annotation databases

EnsemblBacteriaiABZ96221; ABZ96221; LEPBI_I0074
GeneIDi35829446
KEGGilbi:LEPBI_I0074

Similar proteinsi

Entry informationi

Entry nameiG6PI_LEPBP
AccessioniPrimary (citable) accession number: B0SJQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome