B0SJM4 (SURE_LEPBP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE
EC=3.1.3.5

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase

Gene names

Name:	surE
Ordered Locus Names:	LEPBI_I0458

Organism

Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris) [Complete proteome] [HAMAP]

Taxonomic identifier

456481 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Leptospiraceae › Leptospira

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity.
Subcellular location	Cytoplasm Potential HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 247	247	5'-nucleotidase surE HAMAP MF_00060		PRO_1000092014
Sites
	Metal binding	8	1	Divalent metal cation By similarity
	Metal binding	9	1	Divalent metal cation By similarity
	Metal binding	39	1	Divalent metal cation By similarity
	Metal binding	91	1	Divalent metal cation By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0SJM4 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 9D9FCFF657EEE05A	FASTA	247	27,391
	10 20 30 40 50 60 MNLLITNDDG ISSAGIKALE RVLGKSYNTY LIAPLKERSV TSMALTVFQG MRVERINDNH 70 80 90 100 110 120 YIADGFPVDC VNIGLYAEIF PKIDFVISGI NRGVNMGYDV HYSGTVGAAK HGALHGIPSL 130 140 150 160 170 180 AVSSGRIDPE DGYEKEAELV LAFLEQYKSQ IQSGEIWNLN FPPEVSGTGT ISELVFTRLG 190 200 210 220 230 240 RRRYSEKYEK KQIIEGVSEF QLNGSLLGHD EETGTDFEAY AQGKIPLTPI QLDLTEKNRL KELLTNR

References

[1]

"Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis." Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N., Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A., Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L., Rood J.I., Lajus A. , Davies J.K., Medigue C., Adler B. PLoS ONE 3:E1607-E1607(2008) [PubMed: 18270594] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Patoc 1 / ATCC 23582 / Paris.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000786 Genomic DNA. Translation: ABZ96597.1.
RefSeq	YP_001837873.1. NC_010602.1.
3D structure databases
ProteinModelPortal	B0SJM4.
ModBase	Search...
Protein-protein interaction databases
STRING	B0SJM4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6223352.
GenomeReviews	Gene locus LEPBI_I0458 in contig CP000786_GR.
KEGG	lbi:LEPBI_I0458.
PATRIC	22347610. VBILepBif123590_0459.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG600532.
OMA	GHEIWHS.
ProtClustDB	CLSK575020.
Enzyme and pathway databases
BioCyc	LBIF456481:LEPBI_I0458-MONOMER.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

SURE_LEPBP

Accession

Primary (citable) accession number: B0SJM4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	April 8, 2008
Last modified:	January 25, 2012
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program