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B0SJ25

- PDXJ_LEPBP

UniProt

B0SJ25 - PDXJ_LEPBP

Protein

Pyridoxine 5'-phosphate synthase

Gene

pdxJ

Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.UniRule annotation

    Catalytic activityi

    1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei7 – 713-amino-2-oxopropyl phosphateUniRule annotation
    Binding sitei18 – 1813-amino-2-oxopropyl phosphateUniRule annotation
    Active sitei43 – 431Proton acceptorUniRule annotation
    Binding sitei45 – 4511-deoxy-D-xylulose 5-phosphateUniRule annotation
    Binding sitei50 – 5011-deoxy-D-xylulose 5-phosphateUniRule annotation
    Active sitei83 – 831Proton acceptorUniRule annotation
    Binding sitei113 – 11311-deoxy-D-xylulose 5-phosphateUniRule annotation
    Sitei166 – 1661Transition state stabilizerUniRule annotation
    Active sitei208 – 2081Proton donorUniRule annotation
    Binding sitei209 – 20913-amino-2-oxopropyl phosphate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. pyridoxine 5'-phosphate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Enzyme and pathway databases

    BioCyciLBIF456481:GCM0-474-MONOMER.
    UniPathwayiUPA00244; UER00313.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyridoxine 5'-phosphate synthaseUniRule annotation (EC:2.6.99.2UniRule annotation)
    Short name:
    PNP synthaseUniRule annotation
    Gene namesi
    Name:pdxJUniRule annotation
    Ordered Locus Names:LEPBI_I0476
    OrganismiLeptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
    Taxonomic identifieri456481 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
    ProteomesiUP000001847: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 260260Pyridoxine 5'-phosphate synthasePRO_1000114815Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer; tetramer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi456481.LEPBI_I0476.

    Structurei

    3D structure databases

    ProteinModelPortaliB0SJ25.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni230 – 23123-amino-2-oxopropyl phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0854.
    HOGENOMiHOG000258095.
    KOiK03474.
    OMAiVPETRQE.
    OrthoDBiEOG6M9F0H.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00279. PdxJ.
    InterProiIPR013785. Aldolase_TIM.
    IPR004569. PyrdxlP_synth_PdxJ.
    [Graphical view]
    PfamiPF03740. PdxJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF63892. SSF63892. 1 hit.
    TIGRFAMsiTIGR00559. pdxJ. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0SJ25-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQLSVNVNK IATLRNSRGG SLPSVLKLSE LILDSGAHGI TVHPRSDERH    50
    ITKQDVFELQ EFLRTYNEKI TKLGISKKEY NIEGEPSERF LDLVLKAKPD 100
    QATLVPVKPG EITSDHGFQF ADQKTFSTLK PIVEAIRKEG IRVSLFMETD 150
    FTFYDQVVAL GAERIELYTG PFAHAFDLSE EKGKEIFTDY QRAAIEANKL 200
    GLAVNAGHDL DTNNLRVFAK LPYLKEVSIG HRLMAQSLVD GLETTVKSYL 250
    KVLSLGNETE 260
    Length:260
    Mass (Da):29,082
    Last modified:April 8, 2008 - v1
    Checksum:iF865749A1E31FBD6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000786 Genomic DNA. Translation: ABZ96614.1.
    RefSeqiYP_001837890.1. NC_010602.1.

    Genome annotation databases

    EnsemblBacteriaiABZ96614; ABZ96614; LEPBI_I0476.
    GeneIDi6223478.
    KEGGilbi:LEPBI_I0476.
    PATRICi22347654. VBILepBif123590_0478.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000786 Genomic DNA. Translation: ABZ96614.1 .
    RefSeqi YP_001837890.1. NC_010602.1.

    3D structure databases

    ProteinModelPortali B0SJ25.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 456481.LEPBI_I0476.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABZ96614 ; ABZ96614 ; LEPBI_I0476 .
    GeneIDi 6223478.
    KEGGi lbi:LEPBI_I0476.
    PATRICi 22347654. VBILepBif123590_0478.

    Phylogenomic databases

    eggNOGi COG0854.
    HOGENOMi HOG000258095.
    KOi K03474.
    OMAi VPETRQE.
    OrthoDBi EOG6M9F0H.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00313 .
    BioCyci LBIF456481:GCM0-474-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00279. PdxJ.
    InterProi IPR013785. Aldolase_TIM.
    IPR004569. PyrdxlP_synth_PdxJ.
    [Graphical view ]
    Pfami PF03740. PdxJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63892. SSF63892. 1 hit.
    TIGRFAMsi TIGR00559. pdxJ. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis."
      Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N., Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A., Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L., Rood J.I., Lajus A.
      , Davies J.K., Medigue C., Adler B.
      PLoS ONE 3:E1607-E1607(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Patoc 1 / ATCC 23582 / Paris.

    Entry informationi

    Entry nameiPDXJ_LEPBP
    AccessioniPrimary (citable) accession number: B0SJ25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3