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B0SJ25

- PDXJ_LEPBP

UniProt

B0SJ25 - PDXJ_LEPBP

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Protein
Pyridoxine 5'-phosphate synthase
Gene
pdxJ, LEPBI_I0476
Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate By similarity.UniRule annotation

Catalytic activityi

1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 713-amino-2-oxopropyl phosphate By similarity
Binding sitei18 – 1813-amino-2-oxopropyl phosphate By similarity
Active sitei43 – 431Proton acceptor By similarity
Binding sitei45 – 4511-deoxy-D-xylulose 5-phosphate By similarity
Binding sitei50 – 5011-deoxy-D-xylulose 5-phosphate By similarity
Active sitei83 – 831Proton acceptor By similarity
Binding sitei113 – 11311-deoxy-D-xylulose 5-phosphate By similarity
Sitei166 – 1661Transition state stabilizer By similarity
Active sitei208 – 2081Proton donor By similarity
Binding sitei209 – 20913-amino-2-oxopropyl phosphate; via amide nitrogen By similarity

GO - Molecular functioni

  1. pyridoxine 5'-phosphate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyridoxine biosynthesis

Enzyme and pathway databases

BioCyciLBIF456481:GCM0-474-MONOMER.
UniPathwayiUPA00244; UER00313.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxine 5'-phosphate synthase (EC:2.6.99.2)
Short name:
PNP synthase
Gene namesi
Name:pdxJ
Ordered Locus Names:LEPBI_I0476
OrganismiLeptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
Taxonomic identifieri456481 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000001847: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Pyridoxine 5'-phosphate synthaseUniRule annotation
PRO_1000114815Add
BLAST

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi456481.LEPBI_I0476.

Structurei

3D structure databases

ProteinModelPortaliB0SJ25.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni230 – 23123-amino-2-oxopropyl phosphate binding By similarity

Sequence similaritiesi

Belongs to the PNP synthase family.

Phylogenomic databases

eggNOGiCOG0854.
HOGENOMiHOG000258095.
KOiK03474.
OMAiVPETRQE.
OrthoDBiEOG6M9F0H.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00279. PdxJ.
InterProiIPR013785. Aldolase_TIM.
IPR004569. PyrdxlP_synth_PdxJ.
[Graphical view]
PfamiPF03740. PdxJ. 1 hit.
[Graphical view]
SUPFAMiSSF63892. SSF63892. 1 hit.
TIGRFAMsiTIGR00559. pdxJ. 1 hit.

Sequencei

Sequence statusi: Complete.

B0SJ25-1 [UniParc]FASTAAdd to Basket

« Hide

MTQLSVNVNK IATLRNSRGG SLPSVLKLSE LILDSGAHGI TVHPRSDERH    50
ITKQDVFELQ EFLRTYNEKI TKLGISKKEY NIEGEPSERF LDLVLKAKPD 100
QATLVPVKPG EITSDHGFQF ADQKTFSTLK PIVEAIRKEG IRVSLFMETD 150
FTFYDQVVAL GAERIELYTG PFAHAFDLSE EKGKEIFTDY QRAAIEANKL 200
GLAVNAGHDL DTNNLRVFAK LPYLKEVSIG HRLMAQSLVD GLETTVKSYL 250
KVLSLGNETE 260
Length:260
Mass (Da):29,082
Last modified:April 8, 2008 - v1
Checksum:iF865749A1E31FBD6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000786 Genomic DNA. Translation: ABZ96614.1.
RefSeqiYP_001837890.1. NC_010602.1.

Genome annotation databases

EnsemblBacteriaiABZ96614; ABZ96614; LEPBI_I0476.
GeneIDi6223478.
KEGGilbi:LEPBI_I0476.
PATRICi22347654. VBILepBif123590_0478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000786 Genomic DNA. Translation: ABZ96614.1 .
RefSeqi YP_001837890.1. NC_010602.1.

3D structure databases

ProteinModelPortali B0SJ25.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 456481.LEPBI_I0476.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ96614 ; ABZ96614 ; LEPBI_I0476 .
GeneIDi 6223478.
KEGGi lbi:LEPBI_I0476.
PATRICi 22347654. VBILepBif123590_0478.

Phylogenomic databases

eggNOGi COG0854.
HOGENOMi HOG000258095.
KOi K03474.
OMAi VPETRQE.
OrthoDBi EOG6M9F0H.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00313 .
BioCyci LBIF456481:GCM0-474-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00279. PdxJ.
InterProi IPR013785. Aldolase_TIM.
IPR004569. PyrdxlP_synth_PdxJ.
[Graphical view ]
Pfami PF03740. PdxJ. 1 hit.
[Graphical view ]
SUPFAMi SSF63892. SSF63892. 1 hit.
TIGRFAMsi TIGR00559. pdxJ. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis."
    Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N., Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A., Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L., Rood J.I., Lajus A.
    , Davies J.K., Medigue C., Adler B.
    PLoS ONE 3:E1607-E1607(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Patoc 1 / ATCC 23582 / Paris.

Entry informationi

Entry nameiPDXJ_LEPBP
AccessioniPrimary (citable) accession number: B0SJ25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: May 14, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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