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B0SJ25

- PDXJ_LEPBP

UniProt

B0SJ25 - PDXJ_LEPBP

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Protein

Pyridoxine 5'-phosphate synthase

Gene

pdxJ

Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.UniRule annotation

Catalytic activityi

1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 713-amino-2-oxopropyl phosphateUniRule annotation
Binding sitei18 – 1813-amino-2-oxopropyl phosphateUniRule annotation
Active sitei43 – 431Proton acceptorUniRule annotation
Binding sitei45 – 4511-deoxy-D-xylulose 5-phosphateUniRule annotation
Binding sitei50 – 5011-deoxy-D-xylulose 5-phosphateUniRule annotation
Active sitei83 – 831Proton acceptorUniRule annotation
Binding sitei113 – 11311-deoxy-D-xylulose 5-phosphateUniRule annotation
Sitei166 – 1661Transition state stabilizerUniRule annotation
Active sitei208 – 2081Proton donorUniRule annotation
Binding sitei209 – 20913-amino-2-oxopropyl phosphate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. pyridoxine 5'-phosphate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyridoxine biosynthesis

Enzyme and pathway databases

BioCyciLBIF456481:GCM0-474-MONOMER.
UniPathwayiUPA00244; UER00313.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxine 5'-phosphate synthaseUniRule annotation (EC:2.6.99.2UniRule annotation)
Short name:
PNP synthaseUniRule annotation
Gene namesi
Name:pdxJUniRule annotation
Ordered Locus Names:LEPBI_I0476
OrganismiLeptospira biflexa serovar Patoc (strain Patoc 1 / ATCC 23582 / Paris)
Taxonomic identifieri456481 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000001847: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Pyridoxine 5'-phosphate synthasePRO_1000114815Add
BLAST

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi456481.LEPBI_I0476.

Structurei

3D structure databases

ProteinModelPortaliB0SJ25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni230 – 23123-amino-2-oxopropyl phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the PNP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0854.
HOGENOMiHOG000258095.
KOiK03474.
OMAiVPETRQE.
OrthoDBiEOG6M9F0H.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00279. PdxJ.
InterProiIPR013785. Aldolase_TIM.
IPR004569. PyrdxlP_synth_PdxJ.
[Graphical view]
PfamiPF03740. PdxJ. 1 hit.
[Graphical view]
SUPFAMiSSF63892. SSF63892. 1 hit.
TIGRFAMsiTIGR00559. pdxJ. 1 hit.

Sequencei

Sequence statusi: Complete.

B0SJ25-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQLSVNVNK IATLRNSRGG SLPSVLKLSE LILDSGAHGI TVHPRSDERH
60 70 80 90 100
ITKQDVFELQ EFLRTYNEKI TKLGISKKEY NIEGEPSERF LDLVLKAKPD
110 120 130 140 150
QATLVPVKPG EITSDHGFQF ADQKTFSTLK PIVEAIRKEG IRVSLFMETD
160 170 180 190 200
FTFYDQVVAL GAERIELYTG PFAHAFDLSE EKGKEIFTDY QRAAIEANKL
210 220 230 240 250
GLAVNAGHDL DTNNLRVFAK LPYLKEVSIG HRLMAQSLVD GLETTVKSYL
260
KVLSLGNETE
Length:260
Mass (Da):29,082
Last modified:April 8, 2008 - v1
Checksum:iF865749A1E31FBD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000786 Genomic DNA. Translation: ABZ96614.1.
RefSeqiWP_012387501.1. NC_010602.1.
YP_001837890.1. NC_010602.1.

Genome annotation databases

EnsemblBacteriaiABZ96614; ABZ96614; LEPBI_I0476.
GeneIDi6223478.
KEGGilbi:LEPBI_I0476.
PATRICi22347654. VBILepBif123590_0478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000786 Genomic DNA. Translation: ABZ96614.1 .
RefSeqi WP_012387501.1. NC_010602.1.
YP_001837890.1. NC_010602.1.

3D structure databases

ProteinModelPortali B0SJ25.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 456481.LEPBI_I0476.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ96614 ; ABZ96614 ; LEPBI_I0476 .
GeneIDi 6223478.
KEGGi lbi:LEPBI_I0476.
PATRICi 22347654. VBILepBif123590_0478.

Phylogenomic databases

eggNOGi COG0854.
HOGENOMi HOG000258095.
KOi K03474.
OMAi VPETRQE.
OrthoDBi EOG6M9F0H.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00313 .
BioCyci LBIF456481:GCM0-474-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00279. PdxJ.
InterProi IPR013785. Aldolase_TIM.
IPR004569. PyrdxlP_synth_PdxJ.
[Graphical view ]
Pfami PF03740. PdxJ. 1 hit.
[Graphical view ]
SUPFAMi SSF63892. SSF63892. 1 hit.
TIGRFAMsi TIGR00559. pdxJ. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis."
    Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N., Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A., Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L., Rood J.I., Lajus A.
    , Davies J.K., Medigue C., Adler B.
    PLoS ONE 3:E1607-E1607(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Patoc 1 / ATCC 23582 / Paris.

Entry informationi

Entry nameiPDXJ_LEPBP
AccessioniPrimary (citable) accession number: B0SJ25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: November 26, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3