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B0SIF0

- B0SIF0_LEPBA

UniProt

B0SIF0 - B0SIF0_LEPBA

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Protein

Alanine racemase

Gene

alr

Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei131 – 1311SubstrateUniRule annotation
Active sitei268 – 2681Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei316 – 3161Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciLBIF355278:GHTJ-3512-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
Ordered Locus Names:LBF_4162Imported
OrganismiLeptospira biflexa serovar Patoc (strain Patoc 1 / Ames)Imported
Taxonomic identifieri355278 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000001846: Chromosome II

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi355278.LBF_4162.

Structurei

3D structure databases

ProteinModelPortaliB0SIF0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiTSADEWI.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0SIF0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQSSQIYLSR SAFSHNIALF RKLIGPKSKF TAVVKSNAYG HGLLATASIA
60 70 80 90 100
LDAGADYLGV NSLEEALSIR RVFSKATILI MGSIPHLKER VAELADENFW
110 120 130 140 150
VMVSRIEEME LLAKLSPTPK IHLKVDTGMS RLGIPHQNAE VIAKEIAEKK
160 170 180 190 200
LPLTGIATHF ASTEDFTEHS HSMLQLGNFQ DTIDTFAKHG FIDLICHCAS
210 220 230 240 250
SASAMLFSEA RMDLVRVGIS LYGLWPSLET KLSLSLMKKD VGMLKPALTW
260 270 280 290 300
KTQIQHIQNL NPGTFVGYGS TFKTTHETRL AVVPVGYYEG LDRKLSNHGY
310 320 330 340 350
MLVHGERAKI LGRICMNMTM LDITHIPDAK IGDDVVIIGK SGNEMISADD
360 370
HATWTGTINY EVVTKILGSF PRIIED
Length:376
Mass (Da):41,498
Last modified:April 8, 2008 - v1
Checksum:i7DA1FEDC37A79876
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000778 Genomic DNA. Translation: ABZ95984.1.
RefSeqiYP_001964897.1. NC_010845.1.

Genome annotation databases

EnsemblBacteriaiABZ95984; ABZ95984; LBF_4162.
GeneIDi6390378.
KEGGilbf:LBF_4162.
PATRICi22346338. VBILepBif95142_3706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000778 Genomic DNA. Translation: ABZ95984.1 .
RefSeqi YP_001964897.1. NC_010845.1.

3D structure databases

ProteinModelPortali B0SIF0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 355278.LBF_4162.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ95984 ; ABZ95984 ; LBF_4162 .
GeneIDi 6390378.
KEGGi lbf:LBF_4162.
PATRICi 22346338. VBILepBif95142_3706.

Phylogenomic databases

eggNOGi COG0787.
HOGENOMi HOG000031444.
KOi K01775.
OMAi TSADEWI.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci LBIF355278:GHTJ-3512-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis."
    Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N., Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A., Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L., Rood J.I., Lajus A.
    , Davies J.K., Medigue C., Adler B.
    PLoS ONE 3:E1607-E1607(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Patoc 1 / AmesImported.

Entry informationi

Entry nameiB0SIF0_LEPBA
AccessioniPrimary (citable) accession number: B0SIF0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3