B0SH49 (DCD_LEPBA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxycytidine triphosphate deaminase
Short name=dCTP deaminase
EC=3.5.4.13

Gene names

Name:	dcd
Ordered Locus Names:	LBF_3134

Organism

Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames) [Complete proteome] [HAMAP]

Taxonomic identifier

355278 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Leptospiraceae › Leptospira

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	dCTP + H2O = dUTP + NH3. HAMAP MF_00146
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP MF_00146
Sequence similarities	Belongs to the dCTP deaminase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	dCTP deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 174	174	Deoxycytidine triphosphate deaminase HAMAP MF_00146		PRO_1000117976

Sequences

	Sequence		Length	Mass (Da)
	B0SH49 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 9FFFE42A75391412	FASTA	174	19,933
	10 20 30 40 50 60 MILTGKEILK RLGSDIKIEP YDEKLLNPNS YNLRLHEDLL VYSEFPLDMK KPNPVRTLKI 70 80 90 100 110 120 PEEGLLLEPG NLYLGRTIEF TETHNLVPML EGRSSIGRLG MFVHITAGFG DVGFKGFWTL 130 140 150 160 170 EIQVTHPLRV YSGVQICQIF YHTVEGEISE YKSGKYQANQ GIQPSLLYKD FEKK

References

[1]

"Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis." Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N., Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A., Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L., Rood J.I., Lajus A. , Davies J.K., Medigue C., Adler B. PLoS ONE 3:E1607-E1607(2008) [PubMed: 18270594] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Patoc 1 / Ames.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000777 Genomic DNA. Translation: ABZ95603.1.
RefSeq	YP_001964181.1. NC_010842.1.
3D structure databases
ProteinModelPortal	B0SH49.
ModBase	Search...
Protein-protein interaction databases
STRING	B0SH49.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6389227.
GenomeReviews	Gene locus LBF_3134 in contig CP000777_GR.
KEGG	lbf:LBF_3134.
PATRIC	22345521. VBILepBif95142_3304.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG553199.
OMA	HQTAGWI.
ProtClustDB	PRK00416.
Enzyme and pathway databases
BioCyc	LBIF355278:LBF_3134-MONOMER.
Family and domain databases
HAMAP	MF_00146. dCTP_deaminase. [Tree]
InterPro	IPR011962. dCTP_deam. [Graphical view]
KO	K01494.
TIGRFAMs	TIGR02274. DCTP_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCD_LEPBA

Accession

Primary (citable) accession number: B0SH49

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 8, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program