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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:LBF_1127
OrganismiLeptospira biflexa serovar Patoc (strain Patoc 1 / Ames)
Taxonomic identifieri355278 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003823261 – 425Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei264N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB0SF64
SMRiB0SF64
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG
OrthoDBiPOG091H04O1

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

B0SF64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSETLFQRS KQVVPGGVHS PVRSFSSVGG TPIFFSEARG AYLKSVEGND
60 70 80 90 100
FIDYCLSFGP LLFGHRHPEI QEVVEDTVNK AWSFGACEPY SLELAEFITE
110 120 130 140 150
RIPWVEKIRF VNSGTEAVMS ALRVARAATG RNKILKFDGC YHGHLDQLLV
160 170 180 190 200
KSGSGLAGLS SSDSKGIGPE IIQNTLVLPL DDESKLEELF QREGSNIACL
210 220 230 240 250
AIEPLPANYG LLPQRIEFLK KCRELTTKYG VLLLFDEVIS GFRVSFQGMA
260 270 280 290 300
GITGIIPDLV CYGKIIGGGF PVGAYAGKRE LMDLVAPSGP VYQAGTLSAN
310 320 330 340 350
PIGMRAGLKT LTKAWTENPY PALESATKQL TDGILTLLSE KGDTNWEAVT
360 370 380 390 400
FGSLFWLKGK TENPIRRIDQ IPGTHKSNFA TLFHKLLKQG VYLAPSGYEV
410 420
GFLSTAHTND IINLTLEKTK KALKD
Length:425
Mass (Da):46,412
Last modified:April 8, 2008 - v1
Checksum:i261C16644B7312E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000777 Genomic DNA Translation: ABZ93651.1
RefSeqiWP_012388165.1, NC_010842.1

Genome annotation databases

EnsemblBacteriaiABZ93651; ABZ93651; LBF_1127
GeneIDi35828962
KEGGilbf:LBF_1127

Similar proteinsi

Entry informationi

Entry nameiGSA_LEPBA
AccessioniPrimary (citable) accession number: B0SF64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health