B0SAW0 (B0SAW0_LEPBA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase EMBL ABZ92887.1

Gene names

Name:	lpxA EMBL ABZ92887.1
Ordered Locus Names:	LBF_0341

Organism

Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames) [Complete proteome] [HAMAP]

Taxonomic identifier

355278 [NCBI]

Taxonomic lineage

Bacteria › Spirochaetes › Spirochaetales › Leptospiraceae › Leptospira

Protein attributes

Sequence length	268 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS010137
Catalytic activity	(R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] + UDP-N-acetylglucosamine = [acyl-carrier-protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine. SAAS SAAS010137
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6. SAAS SAAS010137
Subunit structure	Homotrimer By similarity. SAAS SAAS010137
Subcellular location	Cytoplasm By similarity SAAS SAAS010137.

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS010137 Lipid synthesis
Cellular component	Cytoplasm SAAS SAAS010137
Domain	Repeat SAAS SAAS010137
Molecular function	Acyltransferase SAAS SAAS010137 EMBL ABZ92887.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B0SAW0 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: EA557C42759134C0	FASTA	268	29,146
	10 20 30 40 50 60 MKIHPTAIID PKAELHESVE VGPFCIIEKD VKIGEGTVIE SHVKILSGTR IGKFNKISSG 70 80 90 100 110 120 GSFGGLPQDL AFKPETKTYL EIGDHNHFRE NVIFHRGTIE GKGTVIGSHN YLMGNVHIAH 130 140 150 160 170 180 DVIVGDHNIM VQNTMLAGHV VIGNKVFISG SVGVHQFVRV ADYAMLAGLT KVVKDVPPYA 190 200 210 220 230 240 TVDGHPGLIV SLNVVGMKRA GISADVRLAI KRVYKVIYHS GFNTKQALAE LKKDPNPAPE 250 260 VQKVIEFFET SKRGVVDHRF VSGGSDEE

References

[1]

"Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis." Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N., Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A., Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L., Rood J.I., Lajus A. , Davies J.K., Medigue C., Adler B. PLoS ONE 3:E1607-E1607(2008) [PubMed: 18270594] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000777 Genomic DNA. Translation: ABZ92887.1.
RefSeq	YP_001961465.1. NC_010842.1.
3D structure databases
ProteinModelPortal	B0SAW0.
ModBase	Search...
Protein-protein interaction databases
STRING	B0SAW0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6389750.
GenomeReviews	Gene locus LBF_0341 in contig CP000777_GR.
KEGG	lbf:LBF_0341.
PATRIC	22339563. VBILepBif95142_0360.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG659295.
OMA	LRHAVAM.
ProtClustDB	PRK05289.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR010137. Lipid_A_lpxA. IPR011004. Trimer_LpxA-like. [Graphical view]
KO	K00677.
Pfam	PF00132. Hexapep. 3 hits. [Graphical view]
PIRSF	PIRSF000456. UDP-GlcNAc_acltr. 1 hit.
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01852. Lipid_A_lpxA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

B0SAW0_LEPBA

Accession

Primary (citable) accession number: B0SAW0

Entry history

Integrated into UniProtKB/TrEMBL:	April 8, 2008
Last sequence update:	April 8, 2008
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)