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B0SAB8

- SYL_LEPBA

UniProt

B0SAB8 - SYL_LEPBA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei641 – 6411ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLBIF355278:GHTJ-255-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:LBF_0255
OrganismiLeptospira biflexa serovar Patoc (strain Patoc 1 / Ames)
Taxonomic identifieri355278 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
ProteomesiUP000001846: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 867867Leucine--tRNA ligasePRO_1000091331Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi355278.LBF_0255.

Structurei

3D structure databases

ProteinModelPortaliB0SAB8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi638 – 6425"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiVNIVTND.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0SAB8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNYPFQDIEQ KWQKYWDHHQ TFRTNTHSSK PKYYCLDMFP YPSGAGLHVG
60 70 80 90 100
HPEGYTATDI ISRLKRMEGY EVLHPMGWDA FGLPAERYAM TTGIHPRTTT
110 120 130 140 150
KNNIDTFRRQ IKSLGLSYDW EREISTTHPD YYRWTQWIFL QIYNSYFDRK
160 170 180 190 200
QNKAVPITTL IQTLEREGSL FFEGVELPKG IQFTASEWKS KSRKEKEDIL
210 220 230 240 250
SHFRLVYEAN IPVNWCEALG TVLANEEVEE WTSKGYSVER KPMRQYMMRI
260 270 280 290 300
TAYAERLLND LSLCEWPPST LEMQRNWIGK SEGLELSFHV PSLNKDITVY
310 320 330 340 350
TTRPDTIFGA TYLVLAPEHA LVAELTTPEQ TEAVGQYQKD CSLKSDLERT
360 370 380 390 400
ELNKDKTGVF TGAYAQLPTD PSVKVPIYIS DYVLISYGTG AIMAVPAHDQ
410 420 430 440 450
RDYDFAVKFN LPIKQVIDGK METNLAFDSK DSVCINSSSA EVQLDGKSYK
460 470 480 490 500
DAFQTMVVWA EKKGIGRKKI QFKLRDWLFA RQRYWGEPIP LVHFEDGSPK
510 520 530 540 550
ALSDSELPLV LPDLEEFKPS GTGESPLALA KDWLVYKDPE TGEIGKRETN
560 570 580 590 600
TMPQWAGSCY YYLRYIDPRN NDKLIDPELE KMWMPVEVYV GGAEHAVLHL
610 620 630 640 650
LYSRFWHKIL FDLGHVSTPE PFKKLVHQGL ILGEDKGKMS KSRGNVVNPD
660 670 680 690 700
DVVSEFGADT LRLFEMFMGP FEMSKPWSKN GVDGVFRFLN RVWRLFHSGE
710 720 730 740 750
NESFFVEDIE PNEAEQKTLH RTIKKVKDDI DSFSFNTAVS QMMIFINEFT
760 770 780 790 800
SNPRKPKQVL EPFVLALSPF APHLAEELWA KLGHTDSLAY HPYPKWDEKY
810 820 830 840 850
LIDANITIVV QVNGKMRGEF LAPREIEEKE ALSLAKEVEK AKPFWVGKEI
860
KKEIYVKGKL VNIVVAG
Length:867
Mass (Da):99,943
Last modified:April 8, 2008 - v1
Checksum:iB2315D585FBDB924
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000777 Genomic DNA. Translation: ABZ92800.1.
RefSeqiYP_001961378.1. NC_010842.1.

Genome annotation databases

EnsemblBacteriaiABZ92800; ABZ92800; LBF_0255.
GeneIDi6387435.
KEGGilbf:LBF_0255.
PATRICi22339379. VBILepBif95142_0268.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000777 Genomic DNA. Translation: ABZ92800.1 .
RefSeqi YP_001961378.1. NC_010842.1.

3D structure databases

ProteinModelPortali B0SAB8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 355278.LBF_0255.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABZ92800 ; ABZ92800 ; LBF_0255 .
GeneIDi 6387435.
KEGGi lbf:LBF_0255.
PATRICi 22339379. VBILepBif95142_0268.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi VNIVTND.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci LBIF355278:GHTJ-255-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis."
    Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N., Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A., Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L., Rood J.I., Lajus A.
    , Davies J.K., Medigue C., Adler B.
    PLoS ONE 3:E1607-E1607(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Patoc 1 / Ames.

Entry informationi

Entry nameiSYL_LEPBA
AccessioniPrimary (citable) accession number: B0SAB8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3