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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei641ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:LBF_0255
OrganismiLeptospira biflexa serovar Patoc (strain Patoc 1 / Ames)
Taxonomic identifieri355278 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesLeptospiralesLeptospiraceaeLeptospira

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000913311 – 867Leucine--tRNA ligaseAdd BLAST867

Structurei

3D structure databases

ProteinModelPortaliB0SAB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi638 – 642"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 3 hits
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 3 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B0SAB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYPFQDIEQ KWQKYWDHHQ TFRTNTHSSK PKYYCLDMFP YPSGAGLHVG
60 70 80 90 100
HPEGYTATDI ISRLKRMEGY EVLHPMGWDA FGLPAERYAM TTGIHPRTTT
110 120 130 140 150
KNNIDTFRRQ IKSLGLSYDW EREISTTHPD YYRWTQWIFL QIYNSYFDRK
160 170 180 190 200
QNKAVPITTL IQTLEREGSL FFEGVELPKG IQFTASEWKS KSRKEKEDIL
210 220 230 240 250
SHFRLVYEAN IPVNWCEALG TVLANEEVEE WTSKGYSVER KPMRQYMMRI
260 270 280 290 300
TAYAERLLND LSLCEWPPST LEMQRNWIGK SEGLELSFHV PSLNKDITVY
310 320 330 340 350
TTRPDTIFGA TYLVLAPEHA LVAELTTPEQ TEAVGQYQKD CSLKSDLERT
360 370 380 390 400
ELNKDKTGVF TGAYAQLPTD PSVKVPIYIS DYVLISYGTG AIMAVPAHDQ
410 420 430 440 450
RDYDFAVKFN LPIKQVIDGK METNLAFDSK DSVCINSSSA EVQLDGKSYK
460 470 480 490 500
DAFQTMVVWA EKKGIGRKKI QFKLRDWLFA RQRYWGEPIP LVHFEDGSPK
510 520 530 540 550
ALSDSELPLV LPDLEEFKPS GTGESPLALA KDWLVYKDPE TGEIGKRETN
560 570 580 590 600
TMPQWAGSCY YYLRYIDPRN NDKLIDPELE KMWMPVEVYV GGAEHAVLHL
610 620 630 640 650
LYSRFWHKIL FDLGHVSTPE PFKKLVHQGL ILGEDKGKMS KSRGNVVNPD
660 670 680 690 700
DVVSEFGADT LRLFEMFMGP FEMSKPWSKN GVDGVFRFLN RVWRLFHSGE
710 720 730 740 750
NESFFVEDIE PNEAEQKTLH RTIKKVKDDI DSFSFNTAVS QMMIFINEFT
760 770 780 790 800
SNPRKPKQVL EPFVLALSPF APHLAEELWA KLGHTDSLAY HPYPKWDEKY
810 820 830 840 850
LIDANITIVV QVNGKMRGEF LAPREIEEKE ALSLAKEVEK AKPFWVGKEI
860
KKEIYVKGKL VNIVVAG
Length:867
Mass (Da):99,943
Last modified:April 8, 2008 - v1
Checksum:iB2315D585FBDB924
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000777 Genomic DNA Translation: ABZ92800.1
RefSeqiWP_012387295.1, NC_010842.1

Genome annotation databases

EnsemblBacteriaiABZ92800; ABZ92800; LBF_0255
GeneIDi35831057
KEGGilbf:LBF_0255

Similar proteinsi

Entry informationi

Entry nameiSYL_LEPBA
AccessioniPrimary (citable) accession number: B0SAB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: April 8, 2008
Last modified: April 25, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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