B0S9I4 (G6PI_LEPBA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	LBF_0074

Organism

Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames) [Complete proteome] [HAMAP]

Taxonomic identifier

355278 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Spirochaetales › Leptospiraceae › Leptospira › Leptospira biflexa › Leptospira biflexa serovar Patoc

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP-Rule MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473
Subcellular location	Cytoplasm By similarity HAMAP-Rule MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-HAMAP glycolysis Inferred from electronic annotation. Source: UniProtKB-HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: UniProtKB-HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 450	450	Glucose-6-phosphate isomerase HAMAP-Rule MF_00473		PRO_1000125736
Sites
	Active site	310	1	By similarity
	Active site	424	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0S9I4 [UniParc]. Last modified April 8, 2008. Version 1. Checksum: 835B6BA3CF58CF34	FASTA	450	50,024
	10 20 30 40 50 60 MSNLKISDRF VKPFLDQSKL EKELERAEMA RQTVLNGSGL GNEFLGWVNL PSQTKAEDLQ 70 80 90 100 110 120 NIRKAAELIQ SHSQYLVVVG IGGSYLGARA VIEALTPEFS TPETQKKTVK ILYAGHHLDA 130 140 150 160 170 180 DYHFRLLAFL ENKEFSVNVI SKSGTTTEPA IAFRLLLSLL ERKYGKENIK HRVFATTDRS 190 200 210 220 230 240 KGALKHLADE YKFPTFVIPD DVGGRYSVFT PVGLLPIAAA GFSINKLMDG AKQMESELKS 250 260 270 280 290 300 TASKDGNLAC FYAAIRNGLY SLGKTTEIFV SYNPSFGYVS EWWKQLFGES EGKNGKGIFP 310 320 330 340 350 360 ASVQFTTDLH SMGQYIQDGE RKLMETVIKV EAPKQDVYLT EKTDDNDGLN YLAGKKLSEV 370 380 390 400 410 420 NQSAMLGTLI AHKDGGVPCL EITLPSINEE TLGELLYFYE FSCAVSGYML GVNPFDQPGV 430 440 450 EDYKNNMFAL LGKKGYEKRK EEILSHLGFS

References

[1]

"Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis." Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N., Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A., Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L., Rood J.I., Lajus A. , Davies J.K., Medigue C., Adler B. PLoS ONE 3:E1607-E1607(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Patoc 1 / Ames.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000777 Genomic DNA. Translation: ABZ92621.1.
RefSeq	YP_001961199.1. NC_010842.1.
3D structure databases
ProteinModelPortal	B0S9I4.
SMR	B0S9I4. Positions 11-447.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
STRING	355278.LBF_0074.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABZ92621; ABZ92621; LBF_0074.
GeneID	6388906.
KEGG	lbf:LBF_0074.
PATRIC	22338993. VBILepBif95142_0076.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0166.
HOGENOM	HOG000100403.
KO	K01810.
OMA	EPSLHFV.
OrthoDB	EOG64R61J.
ProtClustDB	CLSK2336180.
Enzyme and pathway databases
BioCyc	LBIF355278:GHTJ-74-MONOMER.
UniPathway	UPA00109; UER00181. UPA00138.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase.
InterPro	IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
PANTHER	PTHR11469. PTHR11469. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_LEPBA

Accession

Primary (citable) accession number: B0S9I4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	April 8, 2008
Last modified:	February 19, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program