pgi

Functionⁱ

Catalytic activityⁱ

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayⁱ: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayⁱ: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:

no protein annotated in this organism
Glucose-6-phosphate isomerase (pgi)
no protein annotated in this organism
no protein annotated in this organism

This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	310	UniRule annotation		1
Active siteⁱ	424	UniRule annotation		1

GO - Molecular functionⁱ

glucose-6-phosphate isomerase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

gluconeogenesis Source: UniProtKB-UniPathway
glycolytic process Source: UniProtKB-UniPathway

Complete GO annotation...

Keywordsⁱ

Molecular function	Isomerase
Biological process	Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00181. UPA00138.

UniPathwayⁱ

UPA00109; UER00181.
UPA00138.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation) Short name: GPIUniRule annotation Alternative name(s): Phosphoglucose isomeraseUniRule annotation Short name: PGIUniRule annotation Phosphohexose isomeraseUniRule annotation Short name: PHIUniRule annotation
Gene namesⁱ	Name:pgiUniRule annotation Ordered Locus Names:LBF_0074
Organismⁱ	Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames)
Taxonomic identifierⁱ	355278 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Spirochaetes › Spirochaetia › Leptospirales › Leptospiraceae › Leptospira › Leptospira biflexa › Leptospira biflexa serovar Patoc

Subcellular locationⁱ

Cytoplasm
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_00473

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_1000125736	1 – 450	Glucose-6-phosphate isomeraseAdd BLAST		450

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B0S9I4.
SMRⁱ	B0S9I4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000100403.
KEGG Orthology (KO) More...KOⁱ	K01810.
OMAⁱ	NNIGEDY.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0EIM.

Family and domain databases

HAMAPⁱ	MF_00473. G6P_isomerase. 1 hit.
InterProⁱ	View protein in InterPro IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS.
PANTHERⁱ	PTHR11469. PTHR11469. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00342. PGI. 1 hit.
PRINTSⁱ	PR00662. G6PISOMERASE.
PROSITEⁱ	View protein in PROSITE PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B0S9I4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSNLKISDRF VKPFLDQSKL EKELERAEMA RQTVLNGSGL GNEFLGWVNL 
        60         70         80         90        100
PSQTKAEDLQ NIRKAAELIQ SHSQYLVVVG IGGSYLGARA VIEALTPEFS 
       110        120        130        140        150
TPETQKKTVK ILYAGHHLDA DYHFRLLAFL ENKEFSVNVI SKSGTTTEPA 
       160        170        180        190        200
IAFRLLLSLL ERKYGKENIK HRVFATTDRS KGALKHLADE YKFPTFVIPD 
       210        220        230        240        250
DVGGRYSVFT PVGLLPIAAA GFSINKLMDG AKQMESELKS TASKDGNLAC 
       260        270        280        290        300
FYAAIRNGLY SLGKTTEIFV SYNPSFGYVS EWWKQLFGES EGKNGKGIFP 
       310        320        330        340        350
ASVQFTTDLH SMGQYIQDGE RKLMETVIKV EAPKQDVYLT EKTDDNDGLN 
       360        370        380        390        400
YLAGKKLSEV NQSAMLGTLI AHKDGGVPCL EITLPSINEE TLGELLYFYE 
       410        420        430        440        450
FSCAVSGYML GVNPFDQPGV EDYKNNMFAL LGKKGYEKRK EEILSHLGFS

Length:450

Mass (Da):50,024

Last modified:April 8, 2008 - v1

Checksum:ⁱ835B6BA3CF58CF34

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000777 Genomic DNA. Translation: ABZ92621.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_012387111.1. NC_010842.1.

Genome annotation databases

EnsemblBacteriaⁱ	ABZ92621; ABZ92621; LBF_0074.
KEGGⁱ	lbf:LBF_0074.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000777 Genomic DNA. Translation: ABZ92621.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_012387111.1. NC_010842.1.

3D structure databases

ProteinModelPortalⁱ	B0S9I4.
SMRⁱ	B0S9I4.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABZ92621; ABZ92621; LBF_0074.
KEGGⁱ	lbf:LBF_0074.

Phylogenomic databases

HOGENOMⁱ	HOG000100403.
KEGG Orthology (KO) More...KOⁱ	K01810.
OMAⁱ	NNIGEDY.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H0EIM.

Enzyme and pathway databases

UniPathwayⁱ	UPA00109; UER00181. UPA00138.

UniPathwayⁱ

UPA00109; UER00181.
UPA00138.

Family and domain databases

HAMAPⁱ	MF_00473. G6P_isomerase. 1 hit.
InterProⁱ	View protein in InterPro IPR001672. G6P_Isomerase. IPR018189. Phosphoglucose_isomerase_CS.
PANTHERⁱ	PTHR11469. PTHR11469. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00342. PGI. 1 hit.
PRINTSⁱ	PR00662. G6PISOMERASE.
PROSITEⁱ	View protein in PROSITE PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G6PI_LEPBA
Accessionⁱ	B0S9I4Primary (citable) accession number: B0S9I4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
	Last sequence update:	April 8, 2008
	Last modified:	June 7, 2017
	This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Documents

PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B0S9I4 (G6PI_LEPBA)

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Glucose-6-phosphate isomerase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycolysis

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: gluconeogenesis

Pathwayⁱ: glycolysis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ