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B0S8X8

- GCH1_LEPBA

UniProt

B0S8X8 - GCH1_LEPBA

Protein

GTP cyclohydrolase 1

Gene

folE

Organism
Leptospira biflexa serovar Patoc (strain Patoc 1 / Ames)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (08 Apr 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi71 – 711ZincUniRule annotation
    Metal bindingi74 – 741ZincUniRule annotation
    Metal bindingi142 – 1421ZincUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
    2. one-carbon metabolic process Source: UniProtKB-HAMAP
    3. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    GTP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciLBIF355278:GHTJ-3322-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase 1UniRule annotation (EC:3.5.4.16UniRule annotation)
    Alternative name(s):
    GTP cyclohydrolase IUniRule annotation
    Short name:
    GTP-CH-IUniRule annotation
    Gene namesi
    Name:folEUniRule annotation
    Ordered Locus Names:LBF_3333
    OrganismiLeptospira biflexa serovar Patoc (strain Patoc 1 / Ames)
    Taxonomic identifieri355278 [NCBI]
    Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesLeptospiraceaeLeptospira
    ProteomesiUP000001846: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 183183GTP cyclohydrolase 1PRO_1000100180Add
    BLAST

    Interactioni

    Subunit structurei

    Homopolymer.UniRule annotation

    Protein-protein interaction databases

    STRINGi355278.LBF_3333.

    Structurei

    3D structure databases

    ProteinModelPortaliB0S8X8.
    SMRiB0S8X8. Positions 1-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase I family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0302.
    HOGENOMiHOG000221222.
    KOiK01495.
    OMAiIAFAILE.
    OrthoDBiEOG6XHC8G.

    Family and domain databases

    HAMAPiMF_00223. FolE.
    InterProiIPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view]
    PANTHERiPTHR11109. PTHR11109. 1 hit.
    PfamiPF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00063. folE. 1 hit.
    PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0S8X8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENLIEEILK QIGEDPNREG LVKTPNRVKK AYDFLTSGYK ADINQLVNGA    50
    IFEENTTGMV LVRDIEMYSL CEHHLLPFYG RAHVAYIPNK KIIGISKIPR 100
    IVDVFARRLQ VQERLTDQIA QAIQETLDPL GVGVVIKAKH LCMMMRGVEK 150
    QNSELFTSSL LGLFKTDPTT RSEFLDLIRT GSH 183
    Length:183
    Mass (Da):20,756
    Last modified:April 8, 2008 - v1
    Checksum:iEF3046CCD38C4B43
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000777 Genomic DNA. Translation: ABZ95799.1.
    RefSeqiYP_001964377.1. NC_010842.1.

    Genome annotation databases

    EnsemblBacteriaiABZ95799; ABZ95799; LBF_3333.
    GeneIDi6390042.
    KEGGilbf:LBF_3333.
    PATRICi22345935. VBILepBif95142_3509.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000777 Genomic DNA. Translation: ABZ95799.1 .
    RefSeqi YP_001964377.1. NC_010842.1.

    3D structure databases

    ProteinModelPortali B0S8X8.
    SMRi B0S8X8. Positions 1-179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 355278.LBF_3333.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABZ95799 ; ABZ95799 ; LBF_3333 .
    GeneIDi 6390042.
    KEGGi lbf:LBF_3333.
    PATRICi 22345935. VBILepBif95142_3509.

    Phylogenomic databases

    eggNOGi COG0302.
    HOGENOMi HOG000221222.
    KOi K01495.
    OMAi IAFAILE.
    OrthoDBi EOG6XHC8G.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci LBIF355278:GHTJ-3322-MONOMER.

    Family and domain databases

    HAMAPi MF_00223. FolE.
    InterProi IPR001474. GTP_CycHdrlase_I.
    IPR018234. GTP_CycHdrlase_I_CS.
    IPR020602. GTP_CycHdrlase_I_dom.
    [Graphical view ]
    PANTHERi PTHR11109. PTHR11109. 1 hit.
    Pfami PF01227. GTP_cyclohydroI. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00063. folE. 1 hit.
    PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
    PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis."
      Picardeau M., Bulach D.M., Bouchier C., Zuerner R.L., Zidane N., Wilson P.J., Creno S., Kuczek E.S., Bommezzadri S., Davis J.C., McGrath A., Johnson M.J., Boursaux-Eude C., Seemann T., Rouy Z., Coppel R.L., Rood J.I., Lajus A.
      , Davies J.K., Medigue C., Adler B.
      PLoS ONE 3:E1607-E1607(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Patoc 1 / Ames.

    Entry informationi

    Entry nameiGCH1_LEPBA
    AccessioniPrimary (citable) accession number: B0S8X8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: April 8, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3