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Protein
Submitted name:

Uncharacterized protein

Gene

fn1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • integrin binding Source: ZFIN

GO - Biological processi

  • adrenal gland development Source: ZFIN
  • cardioblast migration to the midline involved in heart rudiment formation Source: ZFIN
  • cell migration involved in sprouting angiogenesis Source: ZFIN
  • embryonic heart tube development Source: ZFIN
  • embryonic viscerocranium morphogenesis Source: ZFIN
  • endocardial cell differentiation Source: ZFIN
  • establishment of epithelial cell apical/basal polarity Source: ZFIN
  • heart development Source: ZFIN
  • heart field specification Source: ZFIN
  • heart jogging Source: ZFIN
  • heart morphogenesis Source: ZFIN
  • lens fiber cell morphogenesis Source: ZFIN
  • lens morphogenesis in camera-type eye Source: ZFIN
  • single organismal cell-cell adhesion Source: ZFIN
  • somite specification Source: ZFIN
  • somitogenesis Source: ZFIN
  • ventricular system development Source: ZFIN
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-1474228. Degradation of the extracellular matrix.
R-DRE-1474244. Extracellular matrix organization.
R-DRE-1566977. Fibronectin matrix formation.
R-DRE-202733. Cell surface interactions at the vascular wall.
R-DRE-2129379. Molecules associated with elastic fibres.
R-DRE-216083. Integrin cell surface interactions.
R-DRE-3000171. Non-integrin membrane-ECM interactions.
R-DRE-3000178. ECM proteoglycans.
R-DRE-354192. Integrin alphaIIb beta3 signaling.
R-DRE-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-DRE-372708. p130Cas linkage to MAPK signaling for integrins.

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:fn1aImported
Synonyms:fn1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 9

Organism-specific databases

ZFINiZDB-GENE-000426-1. fn1a.

Subcellular locationi

GO - Cellular componenti

  • interstitial matrix Source: ZFIN
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 24802459Sequence analysisPRO_5002754777Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiB0S602.
PeptideAtlasiB0S602.

Expressioni

Gene expression databases

BgeeiB0S602.
ExpressionAtlasiB0S602. differential.

Interactioni

GO - Molecular functioni

  • integrin binding Source: ZFIN

Protein-protein interaction databases

STRINGi7955.ENSDARP00000112231.

Structurei

3D structure databases

ProteinModelPortaliB0S602.
SMRiB0S602. Positions 42-268, 301-460, 608-805, 1265-1355, 1539-1632, 2335-2392.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini44 – 8340Fibronectin type-IInterPro annotationAdd
BLAST
Domaini88 – 13144Fibronectin type-IInterPro annotationAdd
BLAST
Domaini132 – 17544Fibronectin type-IInterPro annotationAdd
BLAST
Domaini177 – 22145Fibronectin type-IInterPro annotationAdd
BLAST
Domaini222 – 26645Fibronectin type-IInterPro annotationAdd
BLAST
Domaini301 – 34040Fibronectin type-IInterPro annotationAdd
BLAST
Domaini351 – 39949Fibronectin type-IIInterPro annotationAdd
BLAST
Domaini411 – 45949Fibronectin type-IIInterPro annotationAdd
BLAST
Domaini464 – 50845Fibronectin type-IInterPro annotationAdd
BLAST
Domaini513 – 55543Fibronectin type-IInterPro annotationAdd
BLAST
Domaini556 – 59944Fibronectin type-IInterPro annotationAdd
BLAST
Domaini607 – 706100Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini711 – 80898Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini809 – 90092Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini907 – 99892Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini999 – 108789Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1088 – 117487Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1175 – 126692Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1268 – 135891Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1359 – 145395Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1454 – 154188Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1542 – 163594Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1636 – 172691Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1727 – 181589Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1816 – 190994Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini1910 – 199889Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini2001 – 209797Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini2195 – 228894Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini2297 – 234145Fibronectin type-IInterPro annotationAdd
BLAST
Domaini2342 – 238443Fibronectin type-IInterPro annotationAdd
BLAST
Domaini2386 – 242641Fibronectin type-IInterPro annotationAdd
BLAST

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IF4N. Eukaryota.
ENOG410Y2NH. LUCA.
GeneTreeiENSGT00830000128240.
HOGENOMiHOG000234344.
HOVERGENiHBG005731.
InParanoidiB0S602.
KOiK05717.
OMAiVTLPHPN.
OrthoDBiEOG7X9G60.
TreeFamiTF329915.

Family and domain databases

Gene3Di2.10.10.10. 2 hits.
2.60.40.10. 17 hits.
InterProiIPR000083. Fibronectin_type1.
IPR003961. FN3_dom.
IPR000562. FN_type2_col-bd.
IPR013783. Ig-like_fold.
IPR013806. Kringle-like.
[Graphical view]
PfamiPF00039. fn1. 11 hits.
PF00040. fn2. 2 hits.
PF00041. fn3. 16 hits.
[Graphical view]
SMARTiSM00058. FN1. 12 hits.
SM00059. FN2. 2 hits.
SM00060. FN3. 17 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 10 hits.
SSF57440. SSF57440. 2 hits.
PROSITEiPS01253. FN1_1. 11 hits.
PS51091. FN1_2. 12 hits.
PS00023. FN2_1. 2 hits.
PS51092. FN2_2. 2 hits.
PS50853. FN3. 17 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0S602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFGGPLGTAL AVALLACAVQ CMPKGTGKHK RQAQEHSVSS VSQDGCVMDG
60 70 80 90 100
QFYGAGEKWE RIYLGSTLLC TCHGVSKIEC KSKPDAEETC YDKVNSRSYR
110 120 130 140 150
VGETYERPKD GMIWDCTCIG SARGKISCTI ANRCHEGGHS YKIGDTWQRP
160 170 180 190 200
HDTGDYMLEC VCLGNGKGEW TCKPVAERCY DNTAGTSYMV GETWEKPYQG
210 220 230 240 250
WMIVDCTCLG EGSGRITCTS RNRCNDQDTR TSYRIGDTWS KTDSRGHVLQ
260 270 280 290 300
CLCTGNGRGE WKCERHASLH TTSLGTGSRV VTNVQPAVYH PQGVPEHPVE
310 320 330 340 350
GSCLTEAGVS YAPGMRWSKA QGSKQMLCTC LGNGVSCEES ESQSQVYGGT
360 370 380 390 400
SGGEPCAFPF VFMGKTFYSC TSEGRNDGQL WCSTSSDFEK DYKYSFCTSN
410 420 430 440 450
NVVVTTRGGN SNGALCQFPF LYNGRNYTDC TADGRRDGMK WCGTTYNFDK
460 470 480 490 500
EQRFGFCPMA AHEEVCTTNE GVMYRVGDQW DRRHDVLGHM MRCTCVGNGR
510 520 530 540 550
GEWSCIAYSQ LKDQCIVDNL TYEVNQTFTK RHDEGYTMNC TCFGQGRGRW
560 570 580 590 600
KCDAIDQCQE PETRVFYQIG ESWDKLIQGI HYRCYCYGNG IGELSCEPQH
610 620 630 640 650
SISGGHRPVQ VIISEAGNQP NSHPIQWNAP ASAHITQYIL KWRPKNTHIQ
660 670 680 690 700
WMEVTIPGHV NSYTIAGLKP GVTYEGQLIS ILRFGRRETT RFDFSTVHGS
710 720 730 740 750
LETSEGETTQ PPRMVDTSES VTEITSSSFV ISWVSASDTV SGFRVEYELS
760 770 780 790 800
EEGGQTGQPM ILDLPHSATS VNISELLPGR KYTVNVYEVT GEGEPNLILT
810 820 830 840 850
TSQTTAPDAP SDHEVEDVAD TSIRISWSKP LAPITGYRVV YTPSEEGSSG
860 870 880 890 900
SVELNLPEHS TSLTLGDLRP GVLYNISIFS VEENQESEPV FVQVTTAGEP
910 920 930 940 950
LAEEVPSPTD LQFYEVSDSK ITITWTSPSS EVSGYRVSVG EVGPDGLIEK
960 970 980 990 1000
EVPYPVTQNA YAEITHLQPG TLYRFFIFSL KSGEESEPLV GEQATKPDPP
1010 1020 1030 1040 1050
TDIYFSNITE DSAVIVWLPP TAQITGYRLF LTVEGSNPKQ LRIPGRLSQY
1060 1070 1080 1090 1100
TLLNLQPDTE YSATLHAERG NVLSEGSIAT FATTPPMGNA PYFSTDVTDT
1110 1120 1130 1140 1150
SIIVSWSPLP KIGYKLTVRP SQGGEAPRDV TSELGSVLIS GLTPGVEYTY
1160 1170 1180 1190 1200
SVQPVISGQE HGNPITRRVV TPLSPPTDLN LESNPNTGKL TVQWNDANIP
1210 1220 1230 1240 1250
DITGYRVTCT PTKGQQGNSL EEFVKAGQNS CTLENLSPGV EYNVSVFTVK
1260 1270 1280 1290 1300
DDMESVPVFT TVTPDVPKIT DLSFINVTDS TIGLSWSPLN STAVTGYRIT
1310 1320 1330 1340 1350
VLAAGDSVPI FVEFVEPTTG FYTVHGLEPG IDYDITVTTV TENGESEPIT
1360 1370 1380 1390 1400
ITQQTAVPAP YGLSFGEVTA DTMLVTWKAP QVPKSSDINQ YIIRYHPVDE
1410 1420 1430 1440 1450
DDETTERTVE GSENFVVLRH LVPNTEYLVS VICVYEGREG SPAIGTQRTV
1460 1470 1480 1490 1500
FDAPVGLQFS DVGTTSFTVR WQAPRAIISG YRIRYQMTSG GRAKEERLPP
1510 1520 1530 1540 1550
SRSHFTLTGL TPETEYSISV YAVSGSRDSL PLTGTQSTIS DAPTDLEVIS
1560 1570 1580 1590 1600
STPTSITVRW DAPSVTVRYY RITHGESGGS DAPLEFMVPG SQSTATIEDL
1610 1620 1630 1640 1650
RPGTDYTITV YAVTGRGDSP ASSTPIHVKH RTDIDSPSQM EVTDVKDNTI
1660 1670 1680 1690 1700
TVRWTPAAGP ISRYRVNATP LTGEGPVLHA ETTSDHTEIT FSGLMPAVEY
1710 1720 1730 1740 1750
SIKVYALGQD GESLPLVENV VTTVDKPKDL SFTDVESSSM RISWDSPDGV
1760 1770 1780 1790 1800
VSSYRVLYYS PEEGERELFP APHGDDESAV LHGLRPGTEY TVKVIALHDQ
1810 1820 1830 1840 1850
SPSTALVGTQ TTGIPGPTRL QFSQVGPTSF TVSWSSSDAS LTGYRVAVSP
1860 1870 1880 1890 1900
KSKSGPTKEE NITPDSTEFH ATGLMPGTDY EVEVYGVKNS LTSPRVKGEI
1910 1920 1930 1940 1950
TTPDNISPPR RVRISNVKDS SITLTWRSKT EAISGFLVEA TPTMGGHNPI
1960 1970 1980 1990 2000
QRTIEPDSRT YTIAGLEPGT NYKINIYTLN GNSRSEPFTL TATTAKPVIS
2010 2020 2030 2040 2050
PPTNLHFTSL ASTSISFTWE PPRSTITGYY VTYEEAGGIP KELTPRPQAA
2060 2070 2080 2090 2100
RTFASISGLI PGTEYIIKIV ALNGAQRSTP LIGKARTQLE IEQLPPQLPN
2110 2120 2130 2140 2150
PSRPHLEVLD VPEDNDNFNN HVHVLGPNRH NTLGQQGQHI YTEYQSFNLG
2160 2170 2180 2190 2200
NNGQQPHHPN HGEPLVYIPL PGADGQRVPV VKVNEGQEAG FPFGGLFNET
2210 2220 2230 2240 2250
NLPQESQTQT TIVWQPVPHT SEYVVWCDPI TEINEKSFQM RLPGTSTSAT
2260 2270 2280 2290 2300
LIGLTSGASY NVLVESVNGD QKQKVLQDVV TVGNSVPGAG VIPTGRDVCY
2310 2320 2330 2340 2350
DSFTATYHEV NTEWERMSET GFKLWCKCLG LGSGHFRCDS SKWCHDSGHN
2360 2370 2380 2390 2400
YRIGEKWDRR AENGHMMSCT CLGNGKGEFK CEPHESTCYD EGKLYQVGNQ
2410 2420 2430 2440 2450
WQKEYLGAIC TCTCYGGQQG WRCENCRRPG AEVDADLIQP PVRTDAFDRY
2460 2470 2480
RENALRKLNI QCPIECLRPD LLADAHSPHD
Length:2,480
Mass (Da):271,960
Last modified:April 8, 2008 - v1
Checksum:iE2C29D4C0DC149EB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323049 Genomic DNA. No translation available.
RefSeqiNP_571595.2. NM_131520.2.
UniGeneiDr.51894.

Genome annotation databases

EnsembliENSDART00000124346; ENSDARP00000112231; ENSDARG00000019815.
GeneIDi100005469.
KEGGidre:100005469.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX323049 Genomic DNA. No translation available.
RefSeqiNP_571595.2. NM_131520.2.
UniGeneiDr.51894.

3D structure databases

ProteinModelPortaliB0S602.
SMRiB0S602. Positions 42-268, 301-460, 608-805, 1265-1355, 1539-1632, 2335-2392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000112231.

Proteomic databases

PaxDbiB0S602.
PeptideAtlasiB0S602.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000124346; ENSDARP00000112231; ENSDARG00000019815.
GeneIDi100005469.
KEGGidre:100005469.

Organism-specific databases

CTDi100005469.
ZFINiZDB-GENE-000426-1. fn1a.

Phylogenomic databases

eggNOGiENOG410IF4N. Eukaryota.
ENOG410Y2NH. LUCA.
GeneTreeiENSGT00830000128240.
HOGENOMiHOG000234344.
HOVERGENiHBG005731.
InParanoidiB0S602.
KOiK05717.
OMAiVTLPHPN.
OrthoDBiEOG7X9G60.
TreeFamiTF329915.

Enzyme and pathway databases

ReactomeiR-DRE-114608. Platelet degranulation.
R-DRE-1474228. Degradation of the extracellular matrix.
R-DRE-1474244. Extracellular matrix organization.
R-DRE-1566977. Fibronectin matrix formation.
R-DRE-202733. Cell surface interactions at the vascular wall.
R-DRE-2129379. Molecules associated with elastic fibres.
R-DRE-216083. Integrin cell surface interactions.
R-DRE-3000171. Non-integrin membrane-ECM interactions.
R-DRE-3000178. ECM proteoglycans.
R-DRE-354192. Integrin alphaIIb beta3 signaling.
R-DRE-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-DRE-372708. p130Cas linkage to MAPK signaling for integrins.

Gene expression databases

BgeeiB0S602.
ExpressionAtlasiB0S602. differential.

Family and domain databases

Gene3Di2.10.10.10. 2 hits.
2.60.40.10. 17 hits.
InterProiIPR000083. Fibronectin_type1.
IPR003961. FN3_dom.
IPR000562. FN_type2_col-bd.
IPR013783. Ig-like_fold.
IPR013806. Kringle-like.
[Graphical view]
PfamiPF00039. fn1. 11 hits.
PF00040. fn2. 2 hits.
PF00041. fn3. 16 hits.
[Graphical view]
SMARTiSM00058. FN1. 12 hits.
SM00059. FN2. 2 hits.
SM00060. FN3. 17 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 10 hits.
SSF57440. SSF57440. 2 hits.
PROSITEiPS01253. FN1_1. 11 hits.
PS51091. FN1_2. 12 hits.
PS00023. FN2_1. 2 hits.
PS51092. FN2_2. 2 hits.
PS50853. FN3. 17 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.
  2. Ensembl
    Submitted (AUG-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.

Entry informationi

Entry nameiB0S602_DANRE
AccessioniPrimary (citable) accession number: B0S602
Entry historyi
Integrated into UniProtKB/TrEMBL: April 8, 2008
Last sequence update: April 8, 2008
Last modified: July 6, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.